You have no items in your shopping cart.
Product Description for Cathepsin B
Properties for Cathepsin B
| Manufacturer | Novus Biologicals Inc. |
| Quantity | 1 ml |
| Reactivity | Human |
| Presentation | Purified |
| Applications | Enzyme Immunoassay |
| Host | Sheep |
| PDF datasheet | view  |
| Shipping to | Not USA/Canada |
Datasheet Extract
| Synonyms | Cathepsin B1, APP secretase, APPS, CTSB, CPSB, Review 026 |
| Swiss Prot Num | P07858 |
| Immunogen | Native, from placenta |
| Product Type | Antibodies |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| Format | Purity: protein G purified |
| Purification: protein G purified | |
| Buffer System: 0.09% Sodium Azide | |
| Specificity | , This antibody detects cathepsin B, a lysosomal cysteine protease which functions as both a endopeptidase and a carboxypeptidase. Together with cathepsins D and L, cathepsin B is one of the most abundant proteases in the lysosome, and participates in intracellular protein degradation. |
| Application | ELISA, ELISA, ELISA 1:1000-1:20000 |
| Background | Cathepsin B is a normal lysosomal proteinase that is expressed in all cells. It is a cysteine endoproteinase structurally and functionally related to the papain family of proteases. Cathepsin B is synthesized as an inactive 43 kDa pro enzyme which, by removal of a 62 amino acid propeptide, is activated to the single chain form of 31 kDa or the two chain form (25 and 5 kDa subunits). Matured Cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins at acidic and neutral pH. Endogenous inhibitors of cysteine proteases, the cystatins and stefins, may play a major role in regulating their activity. In tumor cells and in cells exposed to mitogens, cathepsin B displays altered cellular trafficking resulting in the secretion of the 43 kDa precursor. Elevated levels of Cathepsin B correlate with malignancy suggesting that this enzyme may be a useful prognostic marker for several types of human cancers. Cathepsin B has also been implicated in the pathogenesis of rhematoid arthritis, muscular dystrophy and tumor metastasis. |
| Concentration | 5 mg/ml |
| Review | r026 Antibody Panel to Cathepsin Protease Family |
Secondary Antibodies for Cathepsin B
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1433R | Sheep IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1456AP | Sheep IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / 200 Euro | |||||
| R1456B | Sheep IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / 170 Euro | |||||
| R1456F | Sheep IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / 160 Euro | |||||
| R1456HRP | Sheep IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / 180 Euro | |||||
| R1456T | Sheep IgG (H&L) | ||||||
| Rabbit | TRITC | 2 mg / 160 Euro | |||||
