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Product Description for Superoxide Dismutase 1 (SOD1)
Superoxide dismutase [Cu-Zn]
Properties for Superoxide Dismutase 1 (SOD1)
| Manufacturer | Novus Biologicals Inc. |
| Quantity | 0.5 mg |
| Reactivity | Human, Mouse, Rat |
| Applications | Frozen sections, Western blot / Immunoblot |
| Isotype | IgG |
| Host | Rabbit |
| PDF datasheet | view  |
| Shipping to | Not USA/Canada |
Datasheet Extract
| Synonyms | SOD-1, CuZn-SOD, CuZnSOD, IPOA, ALS1, EC=1.15.1.1, FocusOn112 |
| Swiss Prot Num | P00441 |
| Immunogen | A synthetic peptide from the internal part of human SOD1 (Superoxide dismutase 1, SODC) conjugated to an immunogenic carrier protein was used as the immunogen. The antigen is homologous in rat and mouse., |
| Product Type | Antibodies |
| Immunogen | Swiss Prot Num: P00441 |
| Genename: SOD1 | |
| Storage | Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles. |
| References | , |
| Specificity | Appears to be specific for SOD1., |
| Add. information | Reconstitute in 500 ul of sterile water. Centrifuge to remove any insoluble material., |
| Application | IHC, WB. A concentration of 10-50 ?g/ml is recommended. The optimal concentration should be determined by the end user. Not yet tested in other applications., Immunohistochemistry 10-50 ug/ml, Western Blot. |
| Background | Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn SOD/SOD1), mitochondrial manganese SOD (Mn SOD/SOD2) and extracellular Cu, Zn SOD (EC SOD/SOD3). SOD1 is found in all eukaryotic species as a homodimeric 32 kDa enzyme containing one each of Cu and Zn ion per subunit. The manganese containing 80 kDa tetrameric enzyme SOD2 is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. SOD3 is a heparin binding multimer of disulfide linked dimers, primarily expressed in human lungs, vessel walls and airways. SOD4 is a copper chaperon for superoxide dismutase(CCS), which specifically delivers Cu to copper/zinc superoxide dismutase. CCS may activate copper/zinc superoxide dismutase through direct insertion of the Cu cofactor. |
| Format | Purification: IgG purified |
| Buffer System: Lyophilised | |
| Focuson | 112 Antibody Panel to proteins of the superoxide dismutase enzyme family (SOD1, SOD2, SOD3, SOD4) |
Secondary Antibodies for Superoxide Dismutase 1 (SOD1)
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / 190 Euro | |||||
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / 160 Euro | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / 160 Euro | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / 170 Euro | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / 160 Euro | |||||
| R1427R | Rabbit IgG F(ab)2 Fragment | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1458C2 | Rabbit IgG (H&L) | ||||||
| Goat | Cy2 | 1 mg / 250 Euro | |||||
| R1458C3 | Rabbit IgG (H&L) | ||||||
| Goat | Cy3 | 1 mg / 250 Euro | |||||
| R1458C5 | Rabbit IgG (H&L) | ||||||
| Goat | Cy5 | 1 mg / 250 Euro | |||||
