Properties for 17-AAG
| Product Category | Others |
|---|---|
| Quantity | 1 mg |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Add. information | Synthetic 17-AAG Soluble in DMSO (>20mg/mL) or mehtanol (10mg/mL) Purple solid |
|---|---|
| Application | , Synthetic 17-AAG Soluble in DMSO (>20mg/mL) or mehtanol (10mg/mL) Purple solid |
| Background | Glendanamycin (GA), a benzoquinone ansamycin antibiotic, interferes with the action of Hsp90 leading to degradation of Hsp90 client proteins. GA itself however has undesirable properties such as poor aqueous solubility and liver toxicity; therefore, numerous analogs have been synthesized, such as 17-AAG(1). 17-AAG is an HSP-90 inhibitor that displays a 100-fold higher affinity for HSP-90 derived from tumor cells compared to HSP-90 from normal cells(2). 17-AAG inhibits Akt activation and expression in tumors and synergizes with a number of antitumor agents such as taxol(3), cisplatin(4) and UCN-01 (400 nM 17-AAG, U937 cells)(5). |
| General Readings | 1. Neckers L. (2002) Trends Mol Med. 84: S55-61. 2. Kamal A., et al.(2003) Nature 425: 407. 3. Solit D.B., et al.(2003) Cancer Res. 63: 2139. 4. Vasilevskaya I.A., et al. (2003) Mol.Pharmacol. 2003 65: 235. 5. Jia W., et al.(2003) Blood 102: 1824. |
| Storage | Store at -20C. Avoid freeze-thaw cycles. |
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