AR09318PU-N 14-3-3 protein sigma / SFN (1-248)

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0.1 mg / €250.00
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14-3-3 protein sigma / SFN

AR09318PU-N

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Product Description for 14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN.
Presentation: Purified

Properties for 14-3-3 protein sigma / SFN

Product Category Proteins
Quantity 0.1 mg
Synonyms Epithelial cell marker protein 1, HME1, Stratifin
Presentation Purified
Source E. coli
Species (Protein) Human
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Proteins (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P31947
Purity > 95 %
Background 14-3-3 sigma, also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.
Concentration 1.0 mg/ml (determined by Bradford assay)
General Readings Benzinger A., et al. (2005) Mol Cell Proteomics. 4(6): 785-95.
Wilker E W., et al. (2005) J Biol Chem. 280:18891-18898.
Storage Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Description
Description:
Recombinant human 14-3-3 sigma was expressed in E.coli and purified by using conventional chromatography techniques.
AA Sequence:
MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS
Format
Buffer System:
20 mM Tris-HCl buffer (pH 8.0) containing 50 mM NaCl, 10% glycerol
Purity:
>95% by SDS - PAGE
State:
Liquid purified protein
Purified
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