Product Description for 14-3-3 protein sigma / SFN
Properties for 14-3-3 protein sigma / SFN
|Product Category||Proteins, Peptides & Growth Factors|
|Synonyms||Epithelial cell marker protein 1, HME1, Stratifin|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Material safety datasheet||MSDS for Proteins (de)|
|Purity||> 95 % by SDS - PAGE|
|Background||14-3-3 sigma, also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis.|
|Concentration||1.0 mg/ml (determined by Bradford assay)|
|General Readings||Benzinger A., et al. (2005) Mol Cell Proteomics. 4(6): 785-95.
Wilker E W., et al. (2005) J Biol Chem. 280:18891-18898.
|Storage||Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
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