Product Description for 14-3-3 protein sigma / SFN
14-3-3 protein sigma / SFN.
Presentation: Purified
Presentation: Purified
Properties for 14-3-3 protein sigma / SFN
| Product Category | Proteins |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | Epithelial cell marker protein 1, FocusOn116, HME1, Stratifin |
| Presentation | Purified |
| Source | E. coli |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 95 % |
| Background | 14-3-3 sigma, also known as Stratifin (SFN), belong to the 14-3-3 family. The 14-3-3 family of proteins plays a key regulatory role in signal transduction, checkpoint control, apoptotic and nutrient-sensing pathways. 14-3-3 proteins are highly conserved and ubiquitously expressed. There are at least seven isoforms, beta, gamma, epsilon, sigma, zeta, tau and eta that have been identified in mammals. 14-3-3 sigma was identified as an epithelial cell marker and appeared to function as a tumor suppressor whose expression can be down regulated via methylation. Loss of 14-3-3 sigma expression results in a defective G2/M phase checkpoint and appears to contribute to both epithelial and non-epithelial tumorigenesis. |
| Concentration | 1.0 mg/ml (determined by Bradford assay) |
| General Readings | Benzinger A., et al. (2005) Mol Cell Proteomics. 4(6): 785-95. Wilker E W., et al. (2005) J Biol Chem. 280:18891-18898. |
| Storage | Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| Description |
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| Format |
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| FocusOn and Reviews | |
| Targets |
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