Alpha-Synuclein / SNCA (A30P/A53T Mutant) - SA6003

Product Description for Alpha-Synuclein / SNCA

Alpha-Synuclein / SNCA.
Presentation: Purified

Product Category	Proteins
Quantity	0.1 mg
Synonyms	FocusOn131, NACP, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, PARK1
Presentation	Purified
Molecular weight	14.516 kDa
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Immunogen	Swiss Prot Num: P37840
Purity	> 95 %
Add. information	Real molecular weight on SDS-PAGE will be shift up (see picture below).
Background	Alpha-Synuclein, an acidic neuronal protein, is extremely heat-resistant and is natively unfolded with an extended structure primarily composed of random coils. Alpha-Synuclein has been suggested to be implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders, and more recently, to be an important regulatory component of vesicular transport in neuronal cells. Moreover, recent studies have shown that alpha-synuclein has chaperone activity and that this activity is lost upon removing its C-terminal acidic tail (amino acids 96-140).
General Readings	Kruger R, et al. (1998) Nat Genet. 18, 106-108. Polymeropoulos M. H., et al.. (1997) Science 276, 2045-2047. Park, S. M. et al. (2002) Blood,100(7), 2506-2514.
Storage	Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Description	AA Sequence: `MDVFMKGLSK AKEGVVAAAE KTKQGVAEAP GKTKEGVLYV GSKTKEGVVH GVTTVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA`
Format	Buffer System: 20 mM Tris-HCl buffer (pH 7.5) containing 0.1 M NaCl Purity: by SDS-PAGE State: Liquid protein Purified
Targets	Alpha-Synuclein / SNCA antibody