Product Description for Apolipoprotein A I (APO AI)
Apolipoprotein A I (APO AI).
Properties for Apolipoprotein A I (APO AI)
| Product Category | Proteins |
|---|---|
| Quantity | 0.1 mg |
| Synonyms | APOA1, Apo-AI, ApoA-I, ApoAI, FocusOn036 |
| Molecular weight | 30.3 kDa |
| Shipping to | Not USA/Canada |
| PDF datasheet | View Datasheet |
| Manufacturer | Novus Biologicals Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Add. information | , 30.3 kDa |
| Application | This protein is useful as a positive control., ELISA, Western Blot. |
| Background | Apolipoprotein A I promotes cholesterol efflux from tissues to the liver for excretion. Apolipoprotein A I is the major protein component of high density lipoprotein (HDL) in the plasma. Synthesized in the liver and small intestine, it consists of two identical chains of 77 amino acids; an 18 amino acid signal peptide is removed co-translationally and a 6 amino acid propeptide is cleaved post-translationally. Apolipoprotein A I is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. Defects in the Apolipoprotein A I gene are associated with HDL deficiency and Tangier disease. The therapeutic potential of apoA-I has been recently assessed in patients with acute coronary syndromes, using a recombinant form of a naturally occurring variant of apoA-I. The availability of recombinant normal apoA-I should facilitate further investigation into the potential usefulness of apoA-I in preventing atherosclerotic vascular diseases. |
| Concentration | 1 mg/ml |
| General Readings | , |
| Storage | Store at 4C short term. Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles. |
| Format |
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| FocusOn and Reviews | |
| Targets |
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