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Product Description for Artemin

Artemin.
Presentation: Purified

Properties for Artemin

Product Category	Proteins
Quantity	2 µg
Synonyms	ARTN, EVN, Enovin, Neublastin
Presentation	Purified
Reactivity	Hu
Source	E. coli
Species (Protein)	Human
Shipping to	Worldwide
PDF datasheet	View Datasheet
Manufacturer	Acris Antibodies GmbH

Datasheet Extract

Immunogen	Swiss Prot Num: Q5T4W7
Purity	> 98 %
Add. information	Centrifuge the vial prior to opening!
Background	Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, Persephin and Neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRalpha (alpha1-alpha4) receptors. Artemin prefers the receptor GFRalpha3-RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia such as sympathetic, neural crest and placodally derived sensory neurons, and dompaminergic midbrain neurons. The functional human Artemin ligand is a disulfide-linked homodimer, of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.
General Readings	Cass WA, Protection by GDNF and other trophic factors against the dopamine-depleting effects of neurotoxic doses of methamphetamine Ann N Y Acad Sci., 2006, 1074:272-81. Mikhail Paveliev GDNF family ligands activate multiple events during axonal growth in mature sensory neurons Mol. Cell. Neuroscience, 2004, Vol: 25 (3) pp. 453-459.
Storage	Store the lyophilized protein at -20°C. Reconstituted human Artemin should be stored in working aliquots with a carrier protein at -20°C. Avoid repeated freezing and thawing. Shelf life: one year from despatch.
Source	E.coli
Description	AA Sequence: `AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG.` Biological activity: Determined by it's ability to promote survival and neurite outgrowth and dorsal root ganglion neurons. Molecular weight: 24.2 kDa
Format	Endotoxin level: < 0.1 ng per µg (1EU/µg) State: Lyophilized purified fraction (>98% pure by SDS-PAGE and HPLC analyses) without additives. Purified Reconstitution: Restore in water to a concentration of 0.1-1.0 mg/ml. This solution can then be diluted into other aqueous buffers and stored at 2-8°C for 1 week or -20°C for future use.
Targets	Artemin antibody

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