Product Description for CD309 / VEGFR-2 / Flk-1
CD309 / VEGFR-2 / Flk-1.
Presentation: Purified
Presentation: Purified
Properties for CD309 / VEGFR-2 / Flk-1
| Product Category | Proteins |
|---|---|
| Quantity | 50 µg |
| Synonyms | FLK1, FocusOn005, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2 |
| Presentation | Purified |
| Molecular weight | 160 kDa |
| Source | Insect cells |
| Species (Protein) | Human |
| Shipping to | Worldwide |
| PDF datasheet | View Datasheet |
| Manufacturer | Acris Antibodies GmbH |
Datasheet Extract
| Immunogen |
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|---|---|
| Purity | > 90 % |
| Add. information | Centrifuge vials before opening! |
| Background | Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signalling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1). No naturally occurring, secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin. |
| General Readings |
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| Storage | Store Lyophilized at -20°C to -70°C. Reconstituted sVEGFR-2/Fc should be stored in working aliquots at -20°C. Avoid repeated freeze-thaw cycles! Shelf life: One year from despatch. |
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