Product Description for CD309 / VEGFR-2 / Flk-1
CD309 / VEGFR-2 / Flk-1.
Properties for CD309 / VEGFR-2 / Flk-1
|Synonyms||FLK1, FocusOn005, KDR, Kinase NYK, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1, VEGF Receptor 2, VEGFR2, Vascular endothelial growth factor receptor 2|
|Molecular weight||160 kDa|
|PDF datasheet||View Datasheet|
|Manufacturer||Acris Antibodies GmbH|
|Purity||> 90 %|
|Add. information||Centrifuge vials before opening!|
|Background||Endothelial cells express three different vascular endothelial growth factor (VEGF) receptors, belonging to the family of receptor tyrosine kinases (RTKs). They are named VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1), and VEGFR-3 (Flt-4). Their expression is almost exclusively restricted to endothelial cells, but VEGFR-1 can also be found on monocytes. All VEGF-receptors have seven immunoglobulin-like extracellular domains, a single transmembrane region and an intracellular split tyrosine kinase domain. VEGFR-2 has a lower affinity for VEGF than the Flt-1 receptor, but a higher signalling activity. Mitogenic activity in endothelial cells is mainly mediated by VEGFR-2 leading to their proliferation. Differential splicing of the flt-1 gene leads to the formation of a secreted, soluble variant of VEGFR-1 (sVEGFR-1). No naturally occurring, secreted forms of VEGFR-2 have so far been reported. The binding of VEGF165 to VEGFR-2 is dependent on heparin.|
|Storage||Store Lyophilized at -20°C to -70°C.
Reconstituted sVEGFR-2/Fc should be stored in working aliquots at -20°C.
Avoid repeated freeze-thaw cycles!
Shelf life: One year from despatch.