PA013X Interleukin-6 (IL6)

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10 µg / €230.00
Delivery Time: 3-5 working days

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Interleukin-6 (IL6)

PA013X

Product Description for Interleukin-6 (IL6)

Interleukin-6 (IL6).

Properties for Interleukin-6 (IL6)

Product Category Proteins
Quantity 10 µg
Synonyms B-cell stimulatory factor 2, BSF-2, CDF, CTL differentiation factor, Hybridoma growth factor, IFNB2, IL-6, Interferon beta-2
Molecular weight 21.7 kDa
Source E. coli
Species (Protein) Mouse
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH

Datasheet Extract

Immunogen
Swiss Prot Num:
P08505
Purity > 98 %
Add. information Centrifuge the vial prior to opening.
Background IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R alpha and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells.
Storage The lyophilized protein is stable at -20°C for one year from despatch.
The reconstituted IL-6 is stable for three months when stored in working aliquots with a carrier protein at -20°C.
Avoid repeated freezing and thawing.
Description
AA Sequence:
MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
Biological activity:
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < / = 0.02 ng/ml.
Molecular weight:
(187 aa)
Specific activity:
> / = 5 x 10e7 units/mg
Format
Endotoxin level:
< 0.1 ng per µg (1EU/µg)
Purity:
pure by SDS-PAGE and HPLC analyses.
State:
Sterile filtered Lyophilized protein without additives.
Reconstitution:
Restore in water to a concentration of 0.1-1.0 mg/ml.
This solution can then be diluted into other aqueous buffers and stored at 2-8°C for one week or at -20°C for future use.
Targets