Product Description for PUMA
PUMA.
Properties for PUMA
| Product Category | Proteins |
|---|---|
| Quantity | 50 µg |
| Synonyms | BBC3, Bcl-2-binding component 3, JFY-1, Review 004, p53 up-regulated modulator of apoptosis |
| Shipping to | Europe only |
| PDF datasheet | View Datasheet |
| Manufacturer | GeneTex Inc. |
Datasheet Extract
| Immunogen |
|
|---|---|
| Application | BL |
| Background | Apoptosis is related to many diseases and development. The p53 tumor-suppressor protein induces apoptosis through transcriptional activation of several genes. A novel p53 inducible pro-apoptotic gene was identified recently and designated PUMA (for p53 upregulated modulator of apoptosis) and bbc3 (for Bcl-2 binding component 3) in human and mouse (1-3). PUMA/bbc3 is one of the pro-apoptotic Bcl-2 family members including Bax and Noxa, which are also transcriptional targets of p53. The PUMA gene encodes two BH3 domain-containing proteins termed PUMA-a and PUMA-b (1). PUMA proteins bind Bcl-2, localize to the mitochondria, and induce cytochrome c release and apoptosis in response to p53. PUMA may be a direct mediator of p53-induced apoptosis. |
| Concentration | 0.2 mg/ml |
| Storage | Upon receipt - Keep as concentrated solution. Aliquot and store at -20 |
| Format |
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| FocusOn and Reviews | |
| Targets |
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