Antibodies to Cyclin Family - Product Review 16

Introduction

Oscillations in the activity of the Cdk family of protein kinases drive the eukaryotic cell cycle. These enzymes consist of a catalytic (Cdk) and a regulatory subunit (Cyclin).

Their activity is regulated by phosphorylation of Cdks, binding of stoichiometric kinase inhibitors and regulated proteolysis of the cyclins.The Cdk/cyclin family contains five Cdks (Cdk1, 2, 3, 4 and 6) and four cyclin classes (cyclin A, B, D and E, see table below.) that regulate the cell cycle; three Cdks (Cdk7, 8 and 9) and three cyclin classes (cyclin C, H and T) that regulate transcription. Activating the cell-cycle Cdks requires phosphorylation of a conserved threonine as well as binding of cyclin.

Antibody Tools for Detection of Cyclin Proteins

Acris Antibodies offers a broad panel of monoclonal and polyclonal antibodies for the immunological detection of members of the Cyclin protein family.

Picture Gallery

Staining of human tonsil using DM175 clone 6E6 antibody to Cyclin A1. Note nuclear staining of proliferating cells.

Staining of human tonsil for Cyclin D3 using SM1481

Staining of human placenta for Cyclin E1 using DM181

Available Antibodies to the Cyclin Family

Anti- Cyclin A (CCNA), Cyclin A1 (CCNA1), Cyclin B1 (CCNB), Cyclin B2 (CCNB2), Cyclin B3 (CCNB3), Cyclin C (CCNC), Cyclin D1 (CCND1), Cyclin D2 (CCND2), Cyclin D3 (CCND3), Cyclin E (CCNE), Cyclin E1 (CCNE1), Cyclin E2 (CCNE2), Cyclin G (CCNG), Cyclin G1 (CCNG1), Cyclin G2 (CCNG2), Cyclin H (CCNH), Cyclin I (CCNI), Cyclin J (CCNJ), Cyclin K (CCNK), Cyclin L1 (CCNL1), Cyclin L2 (CCNL2), Cyclin T1 (CCNT1), Cyclin T2 (CCNT2) antibody