Switch to Acris Antibodies Inc. (North America) Switch to Acris Antibodies GmbH (Europe/Worldwide)
Home » Reviews » Antibodies to Cytokeratin Proteins - Product Review 09

Antibodies to Cytokeratin Proteins - Product Review 09

(reset)

Introduction

Intermediate-sized filaments are abundant cytoplasmic structural proteins in most vertebrate cells. Cytokeratins, a group comprising at least 29 different proteins, are characteristic of epithelial and trichocytic cells.

Cytokeratins 1, 4, 5, 6, and 8 are members of the type II neutral-to-basic subfamily. Cytokeratin 1 (68 kDa) is a secondary type II keratin expressed in cornified epithelia. Cytokeratin 4 (59 kDa) is the secondary type II keratin expressed in non-cornified stratified squamous epithelia.

Cytokeratin 5 (58 kDa) is the primary type II keratin in stratified epithelia while cytokeratin type 8 (52 kDa) is the primary type II keratin in simple epithelia. Cytokeratin 6 (56 kDa) is a ’hyperproliferation‘ cytokeratin expressed in tissues with natural or pathological high turnover. The deduced human cytokeratin 7 protein contains 469 amino acids and has a calculated molecular mass of 51.4 kD. Cytokeratin 7 shares 82% amino acid identity with mouse cytokeratin 7 and 76% identity with rat kangaroo cytokeratin 7.

Western blot analysis of mouse tissues detected cytokeratin 7 expression in bladder, but not in epidermis. Cytokeratin 7 expression was found to be restricted to ducts and specific glands of simple epithelial tissues; examples included isolated cells in the acini of mammary gland, cells of lung alveoli and bronchiolar epithelium, kidney collecting duct, and Brunner glands of the duodenum.

Cytokeratins 10, 13, and 18 are members of the type I acidic subfamily. Cytokeratin 10 (56 kDa) is the secondary type I keratin expressed in cornified epithelia. Cytokeratin 13 (54 kDa) is the secondary type I keratin expressed in non-cornified stratified squamous epithelia. Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells.

Cytokeratin 19 (40 kDa) is a type I keratin which can be expressed in both simple and in broad cells of stratifying epithelia at specific sites. Cytokeratin 20 has an apparent molecular mass of about 46 kD. Antibodies raised against cytokeratin 20 decorated typical cytokeratin fibril arrays in normal and transformed intestinal cells.

Immunocytochemical analysis of several human and rat tissues showed that cytokeratin 20 is a prominent component of intestinal and gastric foveolar epithelium, urothelial umbrella cells, and Merkel cells of epidermis. Sparse positive epithelial cells were noted in the thymus, bronchus, gall bladder, and prostate gland. Monoclonal anti-cytokeratin antibodies are specific markers of epithelial cell differentiation and have been widely used as tools in tumor identification and classification.

Antibody Tools for Detection of Cytokeratins

Acris Antibodies offers one of the worlds most comprehensive antibody product ranges for detection of all important keratins. These antibodies are suitable for immunohistochemical staining procedures (see picture gallery below) and / or other applications like Western blotting.

Picture Gallery

Staining of human skin using Pan Cytokeratin Marker AE1+AE3 cat# BM5001. Note cytoplasmic staining of epithelial cells

Staining of human skin using Pan Cytokeratin Marker AE1+AE3 cat# BM5001. Note cytoplasmic staining of epithelial cells

Staining of squamous cell lung carcinoma using pan Cytokeratin marker antibody Lu-5 cat# BM4068. Note cytoplasmic staining of tumor cells.

Staining of squamous cell lung carcinoma using pan Cytokeratin marker antibody Lu-5 cat# BM4068. Note cytoplasmic staining of tumor cells.

Staining of human colon carcinoma using anti Cytokeratin 20 antibody Ke20.8 cat# DM123. Note cytoplasmic staining of tumor cells.

Staining of human colon carcinoma using anti Cytokeratin 20 antibody Ke20.8 cat# DM123. Note cytoplasmic staining of tumor cells.

Staining of squamous cell lung carcinoma using acidic Cytokeratin marker antibody AE1 cat# BM5000 Note cytoplasmic staining of tumor cells.

Staining of squamous cell lung carcinoma using acidic Cytokeratin marker antibody AE1 cat# BM5000 Note cytoplasmic staining of tumor cells.

Staining of human prostata using pan basic Cytokeratin marker antibody DE-SQ cat# DM275. Note staining of basal epithelial cells

Staining of human prostata using pan basic Cytokeratin marker antibody DE-SQ cat# DM275. Note staining of basal epithelial cells

Staining of human colon carcinoma using anti Cytokeratin 19 antibody BA-17 cat# SM1822. Note cytoplasmic staining of tumor cells.

Staining of human colon carcinoma using anti Cytokeratin 19 antibody BA-17 cat# SM1822. Note cytoplasmic staining of tumor cells.

Staining of human tonsil using anti Cytokeratin 4 antibody 6B10 cat# BM559. Note cytoplasmic staining of mucosal epithelial cells

Staining of human tonsil using anti Cytokeratin 4 antibody 6B10 cat# BM559. Note cytoplasmic staining of mucosal epithelial cells

Staining of human mesothelioma using anti Cytokeratin 5, 6, 18 antibody LP34 cat# DM051. Note cytoplasmic staining of tumor cells

Staining of human mesothelioma using anti Cytokeratin 5, 6, 18 antibody LP34 cat# DM051. Note cytoplasmic staining of tumor cells

Staining of human mesothelioma using anti Cytokeratin 5, 6 antibody D5/16B4 cat# DM362. Note cytoplasmic staining of tumor cells

Staining of human mesothelioma using anti Cytokeratin 5, 6 antibody D5/16B4 cat# DM362. Note cytoplasmic staining of tumor cells

Staining of human lung carcinoma using anti Cytokeratin 5, 8 antibody C50 cat# DM182. Note cytoplasmic staining of tumor cells.

Staining of human lung carcinoma using anti Cytokeratin 5, 8 antibody C50 cat# DM182. Note cytoplasmic staining of tumor cells.

Staining of human colon carcinoma using anti Cytokeratin 19 antibody BA-17 cat# SM1822. Note cytoplasmic staining of tumor cells.

Staining of human colon carcinoma using anti Cytokeratin 19 antibody BA-17 cat# SM1822. Note cytoplasmic staining of tumor cells.

Staining of human skin using anti Cytokeratin 6 antibody LHK6B cat# DM271. Note cytoplasmic staining of epiderrmal cells.

Staining of human skin using anti Cytokeratin 6 antibody LHK6B cat# DM271. Note cytoplasmic staining of epiderrmal cells.

Staining of human breast carcinoma using anti Cytokeratin 18 antibody DA-7 cat# SM3044. Note cytoplasmic staining of tumor cells.

Staining of human breast carcinoma using anti Cytokeratin 18 antibody DA-7 cat# SM3044. Note cytoplasmic staining of tumor cells.

Staining of human ovarian carcinoma using anti Cytokeratin 7 antibody OVTL12/30 cat# DM057. Note cytoplasmic staining of tumor cells.

Staining of human ovarian carcinoma using anti Cytokeratin 7 antibody OVTL12/30 cat# DM057. Note cytoplasmic staining of tumor cells.

Staining of human skin using anti Cytokeratin 8, 18 antibody 5D3 cat# DM189. Note cytoplasmic staining of epithelial cells in sweat glands

Staining of human skin using anti Cytokeratin 8, 18 antibody 5D3 cat# DM189. Note cytoplasmic staining of epithelial cells in sweat glands

Staing of human lung using anti Cytokeratin 8 antibody M20 cat# BM5045. Note cytoplasmic staining of bronchial epithelial cells

Staing of human lung using anti Cytokeratin 8 antibody M20 cat# BM5045. Note cytoplasmic staining of bronchial epithelial cells

Staining of human colon carcinoma using anti Cytokeratin 8 antibody 35betaH11 cat# DM054. Note cytoplasmic staining of tumor cells

Staining of human colon carcinoma using anti Cytokeratin 8 antibody 35betaH11 cat# DM054. Note cytoplasmic staining of tumor cells

Staining of human tonsil using anti Cytokeratin 10, 13 antibody DE-K13 cat# DM056. Note cytoplasmic staining of mucosal epithelial cells.

Staining of human tonsil using anti Cytokeratin 10, 13 antibody DE-K13 cat# DM056. Note cytoplasmic staining of mucosal epithelial cells.

Staining of human skin using anti Cytokeratin 10 antibody LHP1 cat# DM185. Note cytoplasmic staining of suprabasal layers of epithelial cells

Staining of human skin using anti Cytokeratin 10 antibody LHP1 cat# DM185. Note cytoplasmic staining of suprabasal layers of epithelial cells

Staining of human skin using anti Cytokeratin 10 antibody DE-K10 cat# DM055. Note cytoplasmic staining of suprabasal layers of epithelial cells

Staining of human skin using anti Cytokeratin 10 antibody DE-K10 cat# DM055. Note cytoplasmic staining of suprabasal layers of epithelial cells

Staining of human tonsil using anti Cytokeratin 13 antibody 1C7 cat# BM5047. Note cytoplasmic staining of mucosal epithelial cells.

Staining of human tonsil using anti Cytokeratin 13 antibody 1C7 cat# BM5047. Note cytoplasmic staining of mucosal epithelial cells.

Staining of rat breast carcinoma using anti Cytokeratin 17 antibody Ks17.E3 cat# DM127. Note cytoplasmic staining of tumor cells.

Staining of rat breast carcinoma using anti Cytokeratin 17 antibody Ks17.E3 cat# DM127. Note cytoplasmic staining of tumor cells.

Staining of squamous cell lung carcinoma using anti Cytokeratin 14 antibody LL002 cat# SM1359. Note cytoplasmic staining of tumor cells.

Staining of squamous cell lung carcinoma using anti Cytokeratin 14 antibody LL002 cat# SM1359. Note cytoplasmic staining of tumor cells.

Staining of human skin using anti Cytokeratin 15 antibody LHK15 cat# DM305. Note cytoplasmic staining of epithelial cells in external rod sheets of hair follicle

Staining of human skin using anti Cytokeratin 15 antibody LHK15 cat# DM305. Note cytoplasmic staining of epithelial cells in external rod sheets of hair follicle

Staing of human lung carcinoma using anti Cytokeratin 16 antibody LL025 cat# SM1471. Note cytoplasmic staining of tumor cells.

Staing of human lung carcinoma using anti Cytokeratin 16 antibody LL025 cat# SM1471. Note cytoplasmic staining of tumor cells.

Staing of human lung carcinoma using anti Cytokeratin 17 antibody Ks17.E3 cat# DM127. Note cytoplasmic staining of tumor cells.

Staing of human lung carcinoma using anti Cytokeratin 17 antibody Ks17.E3 cat# DM127. Note cytoplasmic staining of tumor cells.

 

Available Antibody Panel to Cytokeratins

Anti- Cytokeratin (pan), anti- Cytokeratin-1, -3, -4, -5, -6, -7, -8, -9, -10, -13, -14, -15, -16, -17, -18, -19, and -20 antibody

Items 1 to 20 of 69 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4
69 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
BM6001P

Cytokeratin (basal cell) antibody

Immunofluorescence staining of a 7 days old Zebrafish embryo, showing positive reactivity in epithelia lining the intestine and internal organs. Mouse RCK103 Purified Can, Chk, GP, Hst, Hu, Por, Quail, Rb, Rt, Ze C, F, ICC/IF, WB
0.1 mg / €290.00
  IgG1   Acris Antibodies GmbH
+1 additional image
 
MAB1829

Cytokeratin (basal cell) antibody

Cytokeratin (basal cell) Mouse RCK103 Can, Chk, Hst, Hu, Por, Rb, Rt, S. typhi C, F, ICC/IF, WB
0.1 mg / €400.00
  IgG1   Abnova Taiwan Corp.
 
BM559P

Cytokeratin 4 antibody

Cytokeratin 4 Mouse 6B10 Purified Can, Fe, Hu, Ze C, F, ICC/IF, P, WB
0.1 mg / €310.00
  IgG1   Acris Antibodies GmbH
 
NB110-56915

Cytokeratin 4 antibody

Immunohistochemistry: Cytokeratin 4 Antibody (EP1599Y) [NB110-56915] - Immunohistochemical staining of paraffin-embedded cervical carcinoma using anti-Cytokeratin 4 (cat. #110-56915). Rabbit EP1599Y Purified Hu F, ICC/IF, IP, P, WB
0.1 ml / €390.00
  IgG   Novus Biologicals Inc.
+1 additional image
 
BM5042B

Cytokeratin 5 (+ KRT8) antibody

Cytokeratin 5 Mouse C22 Biotin Amph, Bov, Hu, Hydra, Ms, Por C, E, F, ICC/IF, P
0.25 ml / €330.00
  IgG1   Acris Antibodies GmbH
 
BM5042F

Cytokeratin 5 (+ KRT8) antibody

Cytokeratin 5 Mouse C22 FITC Amph, Bov, Hu, Hydra, Ms, Por C, F, ICC/IF, P
0.25 ml / €330.00
  IgG1   Acris Antibodies GmbH
 
BM6002P

Cytokeratin 5 (+ KRT8) antibody

RCK102 Cytokeratin staining of a human squamous cell carcinoma of the lung. Mouse RCK102 Purified Can, Hst, Hu, Ms, Por, Rb, Rt C, F, ICC/IF, P, WB
0.1 mg / €290.00
  IgG1   Acris Antibodies GmbH
+3 additional images
 
BM6003P

Cytokeratin 7 antibody

Immunohistochemistry on frozen sections of human liver (Left) and swine liver (Right), only bile duct epithelium positive; no reaction in hepatocytes.  Mouse RCK105 Purified Can, Fe, Gt, Hst, Hu, Ms, Rt, Ze C, F, ICC/IF, P, WB
0.1 mg / €290.00
  IgG1   Acris Antibodies GmbH
+1 additional image
 
DM057P

Cytokeratin 7 antibody

Immunohistochemistry on paraffin section of Human colon: no reactivity in the crypt epithelium. Mouse OVTL-12/30 Purified Hu C, F, ICC/IF, P, WB
0.1 mg / €310.00
  IgG1   Acris Antibodies GmbH
+3 additional images
 
NB100-79927

Cytokeratin 7 antibody

Cytokeratin 7 Antibody (EP1620Y) [NB100-79927] - Immunofliorescent staining of HeLa cells using anti-Cytokeratin 7. Rabbit EP1620Y Hu F, ICC/IF, IP, WB
0.1 ml / €390.00
  IgG   Novus Biologicals Inc.
+1 additional image
 
NB120-9021

Cytokeratin 7 antibody

Cytokeratin 7 Mouse RCK105 Can, Fe, Hu, Ms, Por, Rt C, F, ICC/IF, P, WB

Regular Price: 25 µg / €290.00

Special Price: 25 µg / €240.00

  IgG1   Novus Biologicals Inc.
 
MAB1867

Cytokeratin 7 antibody

Cytokeratin 7 Mouse RCK105 Can, Fe, Hst, Hu, Ms, Por, Rt C, F, ICC/IF, WB
0.1 mg / €400.00
  IgG1   Abnova Taiwan Corp.
 
MAB1868

Cytokeratin 7 antibody

Cytokeratin 7 Mouse OVTL12/30 Hu C, F, ICC/IF, P, WB
0.1 mg / €400.00
  IgG1   Abnova Taiwan Corp.
 
BM6004P

Cytokeratin 8 antibody

Immunofluorescence staining of a 7 days old Zebrafish embryo. Mouse H1 Purified Hu, Ze C, F, ICC/IF, P, WB
0.1 mg / €300.00
  IgG1   Acris Antibodies GmbH
 
NB110-56919

Cytokeratin 8 antibody

Immunohistochemistry: Cytokeratin 8 Antibody (EP1628Y) [NB110-56919] - Analysis of paraffin-embedded human breast adenocarcinoma using anti-CK8 (cat. #110-56919). Rabbit EP1628Y Purified Hu, Ms F, ICC/IF, IP, P, WB
0.1 ml / €430.00
  IgG   Novus Biologicals Inc.
+1 additional image
 
GTX29219

Cytokeratin 8 antibody

Cytokeratin 8 Mouse RCK106 Purified Hu C, Dot, F, ICC/IF, WB
0.1 mg / €360.00
  IgG1   GeneTex Inc.
 
BM2298P

Cytokeratin 10 antibody

Figure 1. Immunohistochemistry on frozen section of swine skin: positive staining of the keratinizing layer. Mouse RKSE60 Purified Bov, Can, Hu, Ms, Rt, Ze C, F, ICC/IF, WB
0.1 mg / €290.00
  IgG1   Acris Antibodies GmbH
+3 additional images
 
DM055P

Cytokeratin 10 antibody

Cytokeratin 10 Mouse DE-K10 Purified Can, Fe, Hu C, F, ICC/IF, P, WB
0.1 mg / €310.00
  IgG1   Acris Antibodies GmbH
 
DM056P

Cytokeratin 13 (+ KRT10) antibody

Immunofluorescence staining of a 7 days old Zebrafish embryo. Mouse DE-K13 Purified Fe, Hu, Rt, Ze C, F, ICC/IF, P, WB
0.1 mg / €310.00
  IgG2a   Acris Antibodies GmbH
 
DM3066P

Cytokeratin 14 antibody

Immunohistochemistry on Frozen Section of Human skin. Mouse SPK-14 Supernatant Fe, Hu, Por C, F, ICC/IF, WB
1 ml / €280.00
  IgG1   Acris Antibodies GmbH
 

Items 1 to 20 of 69 total

per page
Page:
  1. 1
  2. 2
  3. 3
  4. 4

Currently Filtering By

  1. Remove This Filter Applications: Flow cytometry (F)
Clear All Filters

Filter Options

Promotions
  1. Promoted products (10)
Product Type
  1. Antibodies (69)
Antibody type
  1. Antibody (Ab) (69)
Clonality
  1. Monoclonal (68)
  2. Polyclonal (1)
Target
  1. Cytokeratin (basal cell) (2)
  2. Cytokeratin 10 (2)
  3. Cytokeratin 13 (1)
  4. Cytokeratin 14 (6)
  5. Cytokeratin 15 (1)
  6. Cytokeratin 16 (1)
  7. Cytokeratin 17 (2)
  8. Cytokeratin 18 (20)
  9. Cytokeratin 19 (10)
  10. Cytokeratin 20 (1)
  11. Cytokeratin 4 (2)
  12. Cytokeratin 5 (3)
  13. Cytokeratin 7 (6)
  14. Cytokeratin 8 (3)
  15. KIAA0649 (1)
  16. pan Cytokeratin (8)
Property
  1. + KRT10 (1)
  2. + KRT13 (1)
  3. + KRT8 (3)
  4. 4+5+6+8+10+13+18 (8)
Reactivity
  1. Human (Hu) (62)
  2. Rat (Rt) (21)
  3. Mouse (Ms) (17)
  4. Canine (Can) (12)
  5. Porcine (Por) (11)
  6. Mammalia (Mam) (10)
  7. Feline (Fe) (9)
  8. Zebrafish (Ze) (9)
  9. Amphibian (Amph) (7)
  10. Hamster (Hst) (7)
  11. Bovine (Bov) (6)
  12. Rabbit (Rb) (4)
  13. Chicken (Chk) (3)
  14. Hydra (2)
  15. Guinea Pig (GP) (1)
  16. Goat (Gt) (1)
  17. Quail (1)
  18. Stapylococcus typhi (S. typhi) (1)
  19. Sheep (Sh) (1)
  20. Trout (1)
  21. Xen (1)
Presentation
  1. Purified (26)
  2. Aff - Purified (10)
  3. FITC (10)
  4. Biotin (3)
  5. PE (3)
  6. APC (2)
  7. Supernatant (1)
Host
  1. Mouse (59)
  2. Rabbit (10)
Images
  1. 1 image (35)
  2. 3+ images (12)
  3. 5+ images (2)
Images: Applications
  1. Paraffin Sections (P) (22)
  2. Immunocytochemistry/​Immunofluorescence (ICC/IF) (12)
  3. Western blot / Immunoblot (WB) (11)
  4. Flow cytometry (F) (8)
  5. Frozen sections (C) (7)
Manufacturer
  1. Acris Antibodies GmbH (34)
  2. Novus Biologicals Inc. (20)
  3. Abnova Taiwan Corp. (10)
  4. GeneTex Inc. (5)
Service
 
© Copyright 1998 - 2013 Acris Antibodies GmbH