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GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22

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The Ligand: GABA

Gamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree of excitability in all brain regions, wheras the level of neuronal activity is regulated by the balance between excitatoric (mostly glutaminergic) and inhibotory (mostly GABA-ergic) signals. GABA exerty ist effects via GABA receptors, which come in three types: GABA A receptors, GABA B receptors and GABA C receptors.

GABA A Receptors

GABA A Receptors (GABAAR) are ligand-controlled chloride channels, composed of 5 subunits. Besides binding GABA, they also bind a number of drugs such as benzodiazepines and barbiturates, making them of primary interest for pharmacological and neurological studies.

GABAAR Subunits

Until now 16 different GABAAR subunits have been identified, which belong to 3 different groups: Alpha (1-6), beta (1-4) and gamma (1-4). In addition delta, epsilon, pie, theta and rho (1-6) subunits have been found. The subunit composition of GABAAR varies in different tissues and determines the pharmacological characteristics of the receptor.

GABAAR Antibodies

Acris Antibodies offers an exceedingly wide range of antibodies for detection of different GABAAR subunits. All antibodies have been tested for Western blot, but part of them also for other applications like ELISA, immunoprecipitation and immunohistochemistry.



Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).

Fig. 2: Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).


In the table below all our antibodies for detection of GABAAR are listed. All GABA A Receptor products: GABA A Receptor antibody, GAA1 antibody, GAA2 antibody, GAA3 antibody, GAA4 antibody, GAA5 antibody, GAA6 antibody, GAB1 antibody, GAB2 antibody, GAB3 antibody, GABRD antibody, GAE antibody, GAG2 antibody, GAG3 antibody, GABRP antibody



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Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
ARP35342_P050

GABRE antibody

GABRE Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €330.00
    AVIVA Systems Biology
 
AP08664PU-N

GABRG2 antibody

Figure 1. Western blot of 10 µg of Rat Hippocampal (Hipp) lysate showing specific immunolabeling of the ~46k Gamma-2 subunit of GABAA-R. Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AP08665PU-N

GABRG2 pSer327 antibody

Figure 1. Western blot of rat cortex showing specific immunolabeling of the ~45k GABAA Gamma-2 protein phosphorylated at Ser327 (Control). Immunolabeling is blocked by the phospho-peptide (peptide) used as antigen but not by the corresponding dephosphopeptide (not shown). Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AVARP13034_P050

GABRP antibody

GABRP Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt P, WB
50 µg / €330.00
    AVIVA Systems Biology
+2 additional images
 
AVARP13034_T100

GABRP antibody

GABRP Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €290.00
    AVIVA Systems Biology
+1 additional image
 
ARP35283_P050

GABRQ antibody

GABRQ Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €330.00
    AVIVA Systems Biology
 

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