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GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22

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The Ligand: GABA

Gamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree of excitability in all brain regions, wheras the level of neuronal activity is regulated by the balance between excitatoric (mostly glutaminergic) and inhibotory (mostly GABA-ergic) signals. GABA exerty ist effects via GABA receptors, which come in three types: GABA A receptors, GABA B receptors and GABA C receptors.

GABA A Receptors

GABA A Receptors (GABAAR) are ligand-controlled chloride channels, composed of 5 subunits. Besides binding GABA, they also bind a number of drugs such as benzodiazepines and barbiturates, making them of primary interest for pharmacological and neurological studies.

GABAAR Subunits

Until now 16 different GABAAR subunits have been identified, which belong to 3 different groups: Alpha (1-6), beta (1-4) and gamma (1-4). In addition delta, epsilon, pie, theta and rho (1-6) subunits have been found. The subunit composition of GABAAR varies in different tissues and determines the pharmacological characteristics of the receptor.

GABAAR Antibodies

Acris Antibodies offers an exceedingly wide range of antibodies for detection of different GABAAR subunits. All antibodies have been tested for Western blot, but part of them also for other applications like ELISA, immunoprecipitation and immunohistochemistry.



Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).

Fig. 2: Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).


In the table below all our antibodies for detection of GABAAR are listed. All GABA A Receptor products: GABA A Receptor antibody, GAA1 antibody, GAA2 antibody, GAA3 antibody, GAA4 antibody, GAA5 antibody, GAA6 antibody, GAB1 antibody, GAB2 antibody, GAB3 antibody, GABRD antibody, GAE antibody, GAG2 antibody, GAG3 antibody, GABRP antibody



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Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
AP08658PU-N

GABAA Receptor alpha 6 antibody

Figure 1. Western blot of mouse forebrain lysates from Wild Type (Control) and Alpha-6-knockout (Alpha6-K/O) animals showing specific immunolabeling of the ~57k Alpha-6 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-6-knockout animals. Rabbit Aff - Purified Bov, Hu, Ms, Rt Dot, WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AP08649PU-N

GABRA1 antibody

Figure 1. Western blot of mouse forebrain lysates from wild type (Control) and Alpha-1 knockout (Alpha-1 K/O) animals showing specific immunolabeling of the ~51k Alpha-1 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-1 knockout animals. Rabbit Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AP08650PU-N

GABRA1 (N-term) antibody

Figure 1. Western blot of mouse forebrain lysates from wild type (Control) and Alpha-1 knockout (Alpha-1 K/O) animals showing specific immunolabeling of the ~51k Alpha-1 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-1 knockout animals. Rabbit Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
ARP34976_P050

GABRA1 antibody

GABRA1 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €330.00
    AVIVA Systems Biology
 
AP08652PU-N

GABRA2 (Cytopl. Dom.) antibody

Figure 1. Western blot of mouse brain lysates from wild type (Control) and Alpha-2 knockout (Alpha-2 K/O) animals showing specific immunolabeling of the ~51k Alpha-2 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-2 knockout animals. Rabbit Aff - Purified Bov, Can, Hu, non-Human Primates, Rt, Ze WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AVARP13026_T100

GABRA2 antibody

GABRA2 Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt P, WB
0.1 mg / €290.00
    AVIVA Systems Biology
+1 additional image
 
AP08653PU-N

GABRA3 (N-term) antibody

Figure 1. Western blot of mouse brain lysates from wild type (Control) and Alpha-3 knockout (Alpha-3 K/O) animals showing specific immunolabeling of the ~51k Alpha-3 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-3 knockout animals. Rabbit Aff - Purified Bov, Can, Hu, non-Human Primates, Rt, Ze WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
ARP34981_T100

GABRA3 antibody

GABRA3 Rabbit Aff - Purified African clawed frog, Bov, Can, Hu, Ms, Rt WB
0.1 mg / €290.00
    AVIVA Systems Biology
 
12979-1-AP

GABRA4 antibody

Mouse skeletal muscle were subjected to SDS PAGE followed by western blot with 12979-1-AP(GABRA4 Antibody) at dilution of 1:1500 Rabbit Aff - Purified Hu, Ms E, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
 
AP16891PU-N

GABRA4 antibody

Antibody (0.1µg/ml) staining of Human Frontal Cortex lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu E, P, WB
0.1 mg / €270.00
    Acris Antibodies GmbH
+1 additional image
 
NBP1-18844

GABRA4 antibody

Immunohistochemistry-Paraffin: GABA A Receptor alpha 4 Antibody [NBP1-18844] - (2.5µg/ml) staining of paraffin embedded Human Cortex. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Goat Aff - Purified Bov, Hu E, WB
0.1 mg / €370.00
  IgG   Novus Biologicals Inc.
+1 additional image
 
AP06129PU-N

GABRB1 antibody

Immunohistochemistry (IHC) analysis of GABA-RB antibody in paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt E, P
0.1 mg / €320.00
    Acris Antibodies GmbH
 
AP08059PU-N

GABRB1 antibody

Figure 1. Western blot analysis of extracts from PC12 cells using GABRB1 antibody AP08059PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €270.00
    Acris Antibodies GmbH
 
AP08059PU-S

GABRB1 antibody

Figure 1. Western blot analysis of extracts from PC12 cells using GABRB1 antibody AP08059PU (Lane 1 and 2). Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €230.00
    Acris Antibodies GmbH
 
AP08659PU-N

GABRB1 antibody

Figure 1. Western blot of rat cerebellar (Cb) and Hippocampal (Hipp) lysates showing specific immunolabeling of the ~55k Beta-1 subunit of the GABAA-R. Rabbit Aff - Purified Can, Chk, Hu, Ms, non-Human Primates, Rt, Xen, Ze WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AP08660PU-N

GABRB2 antibody

Figure 1. Western blot of 7 µg of rat cerebellum (Cb) showing specific immunolabeling of the ~55k Beta-2 subunit of the GABAA-R. Rabbit Aff - Purified Can, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
ARP34989_P050

GABRB2 antibody

GABRB2 Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
50 µg / €330.00
    AVIVA Systems Biology
 
ARP35338_T100

GABRB2 antibody

GABRB2 Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt, Ze WB
0.1 mg / €290.00
    AVIVA Systems Biology
 
AVARP13032_P050

GABRD antibody

GABRD Rabbit Aff - Purified Bov, Can, Chk, Hu, Ms, Rt P, WB
50 µg / €330.00
    AVIVA Systems Biology
+2 additional images
 
AVARP13032_T100

GABRD antibody

GABRD Rabbit Aff - Purified Can, Hu, Ms, Rt P, WB
0.1 mg / €290.00
    AVIVA Systems Biology
+1 additional image
 

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