GABA A Receptor Regulator of Excitability and Drug Ta - Product Review 22

The Ligand: GABA

Gamma-aminobutyric acid (GABA) is the most abundant and most important neurotransmitter of mammalian brain. GABA controls the degree of excitability in all brain regions, wheras the level of neuronal activity is regulated by the balance between excitatoric (mostly glutaminergic) and inhibotory (mostly GABA-ergic) signals. GABA exerty ist effects via GABA receptors, which come in three types: GABA A receptors, GABA B receptors and GABA C receptors.

GABA A Receptors

GABA A Receptors (GABAAR) are ligand-controlled chloride channels, composed of 5 subunits. Besides binding GABA, they also bind a number of drugs such as benzodiazepines and barbiturates, making them of primary interest for pharmacological and neurological studies.

GABAAR Subunits

Until now 16 different GABAAR subunits have been identified, which belong to 3 different groups: Alpha (1-6), beta (1-4) and gamma (1-4). In addition delta, epsilon, pie, theta and rho (1-6) subunits have been found. The subunit composition of GABAAR varies in different tissues and determines the pharmacological characteristics of the receptor.

GABAAR Antibodies

Acris Antibodies offers an exceedingly wide range of antibodies for detection of different GABAAR subunits. All antibodies have been tested for Western blot, but part of them also for other applications like ELISA, immunoprecipitation and immunohistochemistry.



Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Fig. 1: Western Blot Analysis of GABAAR gamma 3 on rat brain lysates (15 µg) using antibody SP7157 (1:1000).

Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).

Fig. 2: Immunohistochemistry on human intestine paraffin sections using GABAAR-pi antibody AVARP13034. Epithelial cells of intestinal villi are stained positive (see arrows).



In the table below all our antibodies for detection of GABAAR are listed. All GABA A Receptor products: GABA A Receptor antibody, GAA1 antibody, GAA2 antibody, GAA3 antibody, GAA4 antibody, GAA5 antibody, GAA6 antibody, GAB1 antibody, GAB2 antibody, GAB3 antibody, GABRD antibody, GAE antibody, GAG2 antibody, GAG3 antibody, GABRP antibody



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Antibodies

Catalog No. Host Clone/Iso. Pres. React. Applications  
20094

GABA antibody

Staining with GABA (gamma-Aminobutyric Acid) Antibody 20094
Rabbit Serum Ms, Re, Rt C, ICC/IF, P
0.1 ml / €390.00
    ImmunoStar Inc.
 
20095

GABA antibody

Staining with GABA antibody (20095) Rabbit Serum Rt C, ICC/IF, P
0.1 ml / €180.00
    ImmunoStar Inc.
 
AP05917PU-N

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Rabbit Purified Ms, Rt WB
0.1 ml / €490.00
  IgG   Acris Antibodies GmbH
 
AP08657SU-N

GABAA Receptor alpha 6 antibody

Figure 1. Western blot of rat cortex lysate showing immunolabeling of the ~57k Alpha-6 subunit of the GABAA-R.

Rabbit Serum Ms, Rt WB
50 µl / €290.00
  IgG   Acris Antibodies GmbH
 
AP08658PU-N

GABAA Receptor alpha 6 antibody

Figure 1. Western blot of mouse forebrain lysates from Wild Type (Control) and Alpha-6-knockout (Alpha6-K/O) animals showing specific immunolabeling of the ~57k Alpha-6 subunit of the GABAA-R.  The labeling was absent from a lysate prepared from Alpha-6-knockout animals. Rabbit Aff - Purified Bov, Hu, Ms, Rt Dot, WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
NB300-150

GABAA Receptor alpha 6 (N-term) antibody

Western Blot: GABA A receptor alpha 6 Antibody [NB300-150] - Western blot of rat cortex lysate showing immunolabeling of the ~57kDa alpha 6 subunit of the GABAA-R. Rabbit Serum Ms, Rt WB
50 µl / €330.00
    Novus Biologicals Inc.
 
NB300-196

GABAA Receptor alpha 6 antibody

Western Blot: GABA A Receptor alpha 6 Antibody [NB300-196] - Western blot of mouse forebrain lysates from Wild Type (Control) and a6-knockout (a6-K/O) animals showing specific immunolabeling of the ~57k a6-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a6-knockout animals. Rabbit Purified Ms, Rt WB
0.1 ml / €340.00
    Novus Biologicals Inc.
 
PAB9684

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Rabbit Ms, Rt WB
0.1 ml / €350.00
    Abnova Taiwan Corp.
 
AP05913PU-N

GABRA1 antibody

GABRA1 Rabbit Purified Bov, Can, Chk, Hu, Mky, Ms, Rt WB
0.1 ml / €480.00
  IgG   Acris Antibodies GmbH
 
AP05936PU-N

GABRA1 (N-term) antibody

GABRA1 Rabbit Purified Ms, Rt WB
0.1 ml / €490.00
  IgG   Acris Antibodies GmbH
 
AP08648SU-N

GABRA1 antibody

Figure 1. Western blot of rat cortex lysate showing immunolabeling of the ~51k Alpha-1 subunit of the GABAA-R. Rabbit Serum Chk, Ms, Rt WB
50 µl / €280.00
  IgG   Acris Antibodies GmbH
 
AP08649PU-N

GABRA1 antibody

Figure 1. Western blot of mouse forebrain lysates from wild type (Control) and Alpha-1 knockout (Alpha-1 K/O) animals showing specific immunolabeling of the ~51k Alpha-1 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-1 knockout animals. Rabbit Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AP08650PU-N

GABRA1 (N-term) antibody

Figure 1. Western blot of mouse forebrain lysates from wild type (Control) and Alpha-1 knockout (Alpha-1 K/O) animals showing specific immunolabeling of the ~51k Alpha-1 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-1 knockout animals. Rabbit Aff - Purified Bov, Can, Hu, Ms, non-Human Primates, Rt WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
NB300-148

GABRA1 antibody

GABRA1 Rabbit Serum Hu, Rt WB
50 µl / €330.00
    Novus Biologicals Inc.
 
NB300-191

GABRA1 antibody

Western Blot: GABA A receptor alpha 1 subunit Antibody [NB300-191] - Western blot of rat forebrain lysates from Wild Type (Control) and a1-knockout (a1-K/O) animals showing specific immunolabeling of the ~51k alpha1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from alpha1-knockout animals. Rabbit Purified Ms, Rt Dot, WB
0.1 ml / €340.00
    Novus Biologicals Inc.
 
NB300-207

GABRA1 antibody

Western Blot: GABA A Receptor alpha 1 Antibody [NB300-207] - Mouse forebrain lysates from wild type (Control) and a1-knockout (a1-K/O) animals showing specific immunolabeling of the ~51k a1-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a1-knockout animals. Rabbit Aff - Purified Ms, Rt WB
0.1 ml / €340.00
    Novus Biologicals Inc.
 
NBP1-19817

GABRA1 antibody

GABRA1 Rabbit Aff - Purified Hu, Ms, Rt P
0.1 mg / €370.00
    Novus Biologicals Inc.
 
ARP34976_P050

GABRA1 antibody

GABRA1 Rabbit Aff - Purified Bov, Can, Hu, Ms, Rt WB
50 µg / €330.00
    AVIVA Systems Biology
 
AP08651SU-N

GABRA2 antibody

Figure 1. Western blot of 10 µg of rat cortex lysate showing immunolabeling of the ~53k Alpha-2 subunit of the GABAA-R. Rabbit Serum Bov, Can, Chimp, Hu, Ms, Rt WB
50 µl / €290.00
  IgG   Acris Antibodies GmbH
 
AP08652PU-N

GABRA2 (Cytopl. Dom.) antibody

Figure 1. Western blot of mouse brain lysates from wild type (Control) and Alpha-2 knockout (Alpha-2 K/O) animals showing specific immunolabeling of the ~51k Alpha-2 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-2 knockout animals. Rabbit Aff - Purified Bov, Can, Hu, non-Human Primates, Rt, Ze WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 

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