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Product Description for CD305 / LAIR1
Leukocyte-associated immunoglobulin-like receptor 1
Properties for CD305 / LAIR1
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 0.1 mg |
| Reactivity | Human |
| Presentation | Biotin |
| Applications | Flow cytometry |
| Isotype | IgG1 |
| Host | Mouse |
| Clone | NKTA255 |
| PDF datasheet | view  |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | LAIR-1, hLAIR1, FocusOn037, FocusOn114 |
| Swiss Prot Num | Q6GTX8 |
| Immunogen | NK cell lines B12.100 and AM.25 |
| Product Type | Antibodies |
| Recommended Isotype Control | SM10B (for use in human samples) |
| Storage | Store the antibody undiluted at 2-8°C for one month or at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Poggi, A. et al. (1995). p40, a novel surface molecule involved in the regulation of the non-major histocompatibility complex-restricted cytolytic activity in humans. Eur. J. Immunol. 25: 369 - 376. 2. Zocchi, M. R. et al. (2001). Leukocyte-associated Ig-like receptor-1 prevents granulocyte-monocyte colony stimulating factor dependent proliferation and Akt1/PKB alpha activation in primary acute myeloid leukemia cells. Eur. J. Immunol. 31: 3667 - 3675. 3. Poggi, A. et al. (2000). Engagement of the leukocyte-associated Ig-like receptor-1 induces programmed cell death and prevents nuclear translocation in human myeloid leukemias. Eur. J. Immunol. 30: 2751-2758. |
| Format | State: Liquid Ig fraction |
| Label: Biotin | |
| Purification: Protein G affinity chromatography | |
| Buffer System: PBS, pH 7.4, containing 0.09% sodium azide and 1% BSA | |
| Specificity | This antibody recognizes leukocyte-associated Ig-like receptor-1 LAIR-1. Clone NKTA255 is reported to inhibit NK cell triggering via CD16 molecules (see Ref. 1). We recommend the use of SM2048A for this purpose. |
| Application | Flow cytometry: Neat - 1:5. Use 10 ul to label 1x 10e6 cells in 100ul. |
| Background | LAIR-1 is a 40kD cell surface molecule that functions as an inhibitory receptor on natural killer cells, monocytes and T cells. LAIR-1 is also expressed by other haematopoeitic cells including B cells, but is not expressed by non-haematopoietic, platelets or erythrocytes. |
| Concentration | 0.1 mg/ml |
| Focuson | 037 Antibodies to NK-cells: CD335 (NKp46), CD305 (LAIR-1) and KIR – Family |
| Focuson | 114 NK-Cell Markers |
Secondary Antibodies for CD305 / LAIR1
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / 190 Euro | |||||
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / 170 Euro | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / 160 Euro | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / 180 Euro | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / 170 Euro | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment | ||||||
| Rabbit | PE | 1 ml / 290 Euro | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment | ||||||
| Goat | PE | 1 ml / 290 Euro | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / 270 Euro | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / 250 Euro | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / 250 Euro | |||||
