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Product Description for Cathepsin B
Properties for Cathepsin B
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 1 ml |
| Reactivity | Human |
| Presentation | Supernatant |
| Applications | Paraffin Sections |
| Isotype | IgG2b |
| Host | Mouse |
| Clone | CB131 |
| PDF datasheet | view  |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | Cathepsin B1, APP secretase, APPS, CTSB, CPSB, Review 026 |
| Swiss Prot Num | P07858 |
| Immunogen | Recombinant human cathepsin B. |
| Product Type | Antibodies |
| Storage | Store the antibody prior to reconstitution at 2-8°C. Following reconstitution store undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Should this product contain a precipitate we recommend microcentrifugation before use. Avoid repeated freezing and thawing. Shelf life: One year from despatch. |
| Format | Reconstitution: Restore with 1 ml distilled water. |
| State: Lyophilized Tissue Culture Supernatant containing 0.09% Sodium Azide as preservative | |
| Specificity | SM2106P is specific for Cathspsin B, a lysosomal protease expressed in a wide range of tissues, including liver, skeletal muscle and heart. |
| Application | Immunohistochemistry on Paraffin Sections: 1/40-1/80. This product does not require protein digestion pretreatment of Paraffin embedded sections. It does not require antigen retrieval using heat treatment prior to staining of paraffin sections. Positive Control: Skin. Not suitable for Immunohistochemistry on Frozen Sections and Western Blotting. |
| Background | Cathepsin B is a normal lysosomal proteinase that is expressed in all cells. It is a cysteine endoproteinase structurally and functionally related to the papain family of proteases. Cathepsin B is synthesized as an inactive 43 kDa pro enzyme which, by removal of a 62 amino acid propeptide, is activated to the single chain form of 31 kDa or the two chain form (25 and 5 kDa subunits). Matured Cathepsin B is normally localized in the lysosomes where it functions in protein turnover. Cathepsin B is also shown capable of degrading extracellular matrix proteins at acidic and neutral pH. Endogenous inhibitors of cysteine proteases, the cystatins and stefins, may play a major role in regulating their activity. In tumor cells and in cells exposed to mitogens, cathepsin B displays altered cellular trafficking resulting in the secretion of the 43 kDa precursor. Elevated levels of Cathepsin B correlate with malignancy suggesting that this enzyme may be a useful prognostic marker for several types of human cancers. Cathepsin B has also been implicated in the pathogenesis of rhematoid arthritis, muscular dystrophy and tumour metastasis. |
| Review | r026 Antibody Panel to Cathepsin Protease Family |
Secondary Antibodies for Cathepsin B
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1253AP | Mouse IgG (H&L) | ||||||
| Rabbit | AP | 1 mg / 190 Euro | |||||
| R1253B | Mouse IgG (H&L) | ||||||
| Rabbit | Biotin | 2 mg / 170 Euro | |||||
| R1253F | Mouse IgG (H&L) | ||||||
| Rabbit | FITC | 2 mg / 160 Euro | |||||
| R1253HRP | Mouse IgG (H&L) | ||||||
| Rabbit | HRP | 2 mg / 180 Euro | |||||
| R1253TR | Mouse IgG (H&L) | ||||||
| Rabbit | Texas Red | 2 mg / 170 Euro | |||||
| R1403R | Mouse IgG (H&L) F(ab')2 Fragment | ||||||
| Rabbit | PE | 1 ml / 290 Euro | |||||
| R1405R | Mouse IgG (H&L) F(ab')2 Fragment | ||||||
| Goat | PE | 1 ml / 290 Euro | |||||
| R1455R | Mouse IgG (H&L) F(ab')2 Fragment multi-species ads. | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1457C2 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy2 | 1 mg / 270 Euro | |||||
| R1457C3 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy3 | 1 mg / 250 Euro | |||||
| R1457C5 | Mouse IgG (H&L) multi-species ads. | ||||||
| Goat | Cy5 | 1 mg / 250 Euro | |||||
