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Product Description for 5-HT1B / HTR1B
Serotonin 1D beta receptor, serotonin 5-ht-1b receptor, serotonin 5-ht-1d-beta receptor
Properties for 5-HT1B / HTR1B
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 0.1 mg |
| Reactivity | Human, Mouse, Rat |
| Presentation | Purified |
| Applications | Western blot / Immunoblot |
| Host | Rabbit |
| PDF datasheet | view  |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | 5-Hydroxytryptamine Receptor 1B, Serotonin Receptor 1B, 5-HT-1D-beta, 5-HT-1B, S12, HTR1DB, FocusOn042 |
| Swiss Prot Num | P28564 |
| Immunogen | Mixture of synthetic peptides corresponding to amino acids 8-26 and 263-278 of Rat 5-HT1BR (Ref.6). |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Petrouka, SJ. Trends Neurosci. 11: 486-500 (1998). 2. De Vivo, M., Mayani, S. J. Pharmacol. Exp. Ther. 238: 248-252 (1986). 3. Pazos, A., Cortes, R., Palacios, JM. Brain Res. 345: 231-249 (1985). 4. Pazos, A. and Palcios, JM. Brain Res. 346: 205-230 (1985). 5. Bruinvels, AT.,et al. Neurophramacol. 33: 367-386 (1994). 6. Voigt,M.M.,et al. EMBO J. 10 (13) 4017-4023 (1991) |
| Format | State: Liquid purified IgG fraction. |
| Purification: Protein G Chromatography | |
| Buffer System: PBS pH 7.2 with 0.02% Sodium Azide as preservative.. | |
| Specificity | This polyclonal antibody detects 5-HT1BR in brain cell lysates. |
| Application | Western blot (1 µg/ml). Recommended Positive Control: Human, Mouse or Rat brain. |
| Background | Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1). Molecular cloning studies have identified 5 receptors belonging to the 5-HT1 subtypes. These receptors are negatively coupled to adenylyl cyclase (2). Radioligand binding studies suggest the presence of 5-HT1B (formerly known as 5-HT1DbR) sites in substantia nigra, dorsal subiculum, globus pallidus, and superior collicum (3,4). The in situ hybridization studies show abundance of 5-HT1BR mRNA in CA1 pyramidal cells of hippocampus, Purkinje cells of cerebellum, olfactory tubercle, subthalamic nucleus and somewhat lower levels in the caudate-putamen, cortical areas, thalamic and hypothalamic nuclei (5). |
| Concentration | 0.5 mg/ml |
| Species Reactivity | Tested: Human, Mouse and Rat. |
| Focuson | 042 Antibodies to 5-hydroxytryptamine (Serotonin) Receptors |
Secondary Antibodies for 5-HT1B / HTR1B
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / 190 Euro | |||||
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / 160 Euro | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / 160 Euro | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / 170 Euro | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / 160 Euro | |||||
| R1427R | Rabbit IgG F(ab)2 Fragment | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1458C2 | Rabbit IgG (H&L) | ||||||
| Goat | Cy2 | 1 mg / 250 Euro | |||||
| R1458C3 | Rabbit IgG (H&L) | ||||||
| Goat | Cy3 | 1 mg / 250 Euro | |||||
| R1458C5 | Rabbit IgG (H&L) | ||||||
| Goat | Cy5 | 1 mg / 250 Euro | |||||
