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Product Description for 5-HT1D / HTR1D
5-hydroxytryptamine (serotonin) receptor 1D, RDC4
Properties for 5-HT1D / HTR1D
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 0.1 mg |
| Reactivity | Human, Mouse, Rat |
| Presentation | Purified |
| Applications | Western blot / Immunoblot |
| Host | Rabbit |
| PDF datasheet | view  |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | 5-hydroxytryptamine Receptor 1D, 5-HT-1D 5-HT-1D-alpha, Serotonin receptor 1D, HTR1DA, HTRL, FocusOn042 |
| Swiss Prot Num | P28221 |
| Immunogen | Mixture of synthetic peptides corresponding to amino acids 1-18 and 251-267 of rat 5-HT1DR (Genbank accession no. NP_036984) (7). |
| Product Type | Antibodies |
| Storage | Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Petrouka, SJ. Trends Neurosci. 11: 486-500 (1998). 2. Lauder, JM. Trends Neurosci. 16: 233-240 (1993). 3. Weinshank, RL., Zgombick, JM., Macchi, MJ., Branchek, TA., Hartig, PR. Proc. Acad. Natl. Sci. USA 89: 3630-3633 (1992). 4. Gerhardt, CC. And van Heerikhuizen, H. Eur. J. Pharmacol. 334: 1-23 (1997). 5. Leonhardt, S., Herrick-Davis, K., Titeler, M. Proc. Natl. Acad. Sci. USA 89: 5517-5521 (1989). 6. Miller, KJ. And Teitker, M. Neurosci. Lett. 136: 223-226 (1992). 7. Hamblin,M.W., McGuffin,R.W., Metcalf,M.A., Dorsa, et al. Mol. Cell. Neurosci. 3, 578-587 (1992). |
| Format | State: Liquid purified Ig fraction |
| Purification: Protein G chromatography | |
| Buffer System: PBS containing 0.02% sodium azide | |
| Specificity | This polyclonal antibody can be used for detection of 5-HT1DR in brain. |
| Application | Western blotting (2 µg/ml). A 40 kDa band is detected. |
| Background | Serotonin (5-hydroxytryptamine, 5-HT), originally discovered as a serum factor plays important roles in regulating diverse biological processes in central and peripheral nervous systems, cardiovascular systems, and gastrointestinal systems (1,2). The 5-HT1D (formerly known as 5-HT1Da) receptor has 63% overall structural homology with the 5-HT1B receptor and a 77% amino acid sequence homology in the seven transmembrane domains (3). In situ hybridization studies have detected highest level of mRNA in primary olfactory cortex, accumbens nucleus, caudate putamen, lateral mammilary nucleus and medial vestibular nucleus (4). The presence of relatively high levels of 5-HT1D mRNA in the locus coeruleus suggest that, when expressed on nerve terminals, this receptor could modulate the release of catecholamines. The 5-HT1D receptor may function as an autoreceptor. Like 5-HT1B receptors, 5-HT1D receptors also appear to act as heteroreceptors. Acting on the 5-HT1D receptors, 5-HT appears to inhibit release of glutamate from rat cerebellar synaptosomes and acetylcholine from guinea pig hippocampal synaptosomes (5). It has been suggested that neurogenic inflammation and nociceptive activity within trigemino- vascular afferents. Endothelium-dependent relaxation in the pig coronary artery has been claimed to be mediated by 5-HT1D receptors (6). Like other members of the 5-HT1 family, 5-HT1D receptors are negatively coupled to adenylate cyclase. |
| Concentration | 0.5 mg/ml |
| Focuson | 042 Antibodies to 5-hydroxytryptamine (Serotonin) Receptors |
Secondary Antibodies for 5-HT1D / HTR1D
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / 190 Euro | |||||
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / 160 Euro | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / 160 Euro | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / 170 Euro | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / 160 Euro | |||||
| R1427R | Rabbit IgG F(ab)2 Fragment | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1458C2 | Rabbit IgG (H&L) | ||||||
| Goat | Cy2 | 1 mg / 250 Euro | |||||
| R1458C3 | Rabbit IgG (H&L) | ||||||
| Goat | Cy3 | 1 mg / 250 Euro | |||||
| R1458C5 | Rabbit IgG (H&L) | ||||||
| Goat | Cy5 | 1 mg / 250 Euro | |||||
