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Product Description for RGS2
G0/G1 switch regulatory protein 8, Cell growth-inhibiting gene 31 protein
Properties for RGS2
| Manufacturer | Acris Antibodies GmbH |
| Quantity | 0.1 mg |
| Reactivity | Human, Mouse, Rat |
| Presentation | Purified |
| Applications | Western blot / Immunoblot |
| Host | Rabbit |
| PDF datasheet | view  |
| Shipping to | Worldwide |
Datasheet Extract
| Synonyms | Regulator of G-protein signaling 2, G0S8, FocusOn111 |
| Swiss Prot Num | P41220 |
| Immunogen | A synthetic peptide within amino acid residues 1-50 of human RGS2 |
| Product Type | Antibodies |
| Immunogen | Swiss Prot Num: P41220 |
| Remarks: The amino acid sequence used is 86% homologous in mouse and rat. | |
| Storage | Store the antibody at 2-8°C for one month or in aliquots at -20°C for longer. Avoid repeated freezing and thawing. Shelf life: one year from despatch. |
| References | 1. Salim,S., Sinnarajah,S., Kehrl,J.H. and Dessauer,C.W. Identification of RGS2 and type V adenylyl cyclase interaction sites J. Biol. Chem. 278 (18), 15842-15849 (2003) 2. Nlend,M.C., Bookman,R.J., Conner,G.E. and Salathe,M. Regulator of G-protein signaling protein 2 modulates purinergic calcium and ciliary beat frequency responses in airway epithelia. Am. J. Respir. Cell Mol. Biol. 27 (4), 436-445 (2002). 3. Sun X, Kaltenbronn K, Steinberg T, Blumer K. RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol. 2004 Nov 24; [Epub ahead of print]. 4. Hepler, J.R. Emerging roles for RGS proteins in cell signalling. Trends Pharmacol Sci. 20(9):376-382 (1999). 5. Le TH, Coffman TM. RGS2: a "turn-off" in hypertension. J Clin Invest. 111(4): 441-443 (2003). 6. Calo,L.A., Pagnin,E., Davis,P.A., Sartori,M., Ceolotto,G., et al. Increased expression of regulator of G protein signaling-2 (RGS-2) in Bartter's/Gitelman's syndrome. A role in the control of vascular tone and implication for hypertension. J. Clin. Endocrinol. Metab. 89 (8), 4153-4157 (2004). |
| Format | State: Liquid Ig fraction |
| Purification: Protein G chromatography | |
| Buffer System: PBS containing 0.2% gelatin and 0.05% sodium azide | |
| Specificity | This antibody is specific for RGS2. |
| Application | Western blot (1-3 µg/ml). Positive control: Human heart lysate. |
| Background | Regulators of G-protein signaling (RGSs) are a protein family containing a conserved 120 amino acid domain (RGS domain), which bind directly to activated G-alpha subunits (Gai and Gaq) and act as GTPase-activating proteins (GAPs). One of these proteins, RGS2, is expressed in thyroid, heart. thyroid, and monocyte-derived DCs. The function of RGS2 as a regulator of Gq is also dependent on regulatory sequences in its amino-terminal domain that direct its localization to the plasma membrane. Recent studies have shown that RGS2 is critical for blood pressure homeostasis, and has been suggested to serve as an effector of the NO-cGMP pathway that promotes vascular relaxation based on studies of aortic rings in vitro. |
| Concentration | 0.5 mg/ml |
| Focuson | 111 Regulators of G-Protein Signaling |
Secondary Antibodies for RGS2
| Catalog No. | Name / Host | Presentation | Reactivity | ||||
|---|---|---|---|---|---|---|---|
| R1364AP | Rabbit IgG (H&L) | ||||||
| Goat | AP | 1 mg / 190 Euro | |||||
| R1364B | Rabbit IgG (H&L) | ||||||
| Goat | Biotin | 2 mg / 160 Euro | |||||
| R1364F | Rabbit IgG (H&L) | ||||||
| Goat | FITC | 2 mg / 160 Euro | |||||
| R1364HRP | Rabbit IgG (H&L) | ||||||
| Goat | HRP | 2 mg / 170 Euro | |||||
| R1364T | Rabbit IgG (H&L) | ||||||
| Goat | TRITC | 2 mg / 160 Euro | |||||
| R1427R | Rabbit IgG F(ab)2 Fragment | ||||||
| Donkey | PE | 1 ml / 290 Euro | |||||
| R1458C2 | Rabbit IgG (H&L) | ||||||
| Goat | Cy2 | 1 mg / 250 Euro | |||||
| R1458C3 | Rabbit IgG (H&L) | ||||||
| Goat | Cy3 | 1 mg / 250 Euro | |||||
| R1458C5 | Rabbit IgG (H&L) | ||||||
| Goat | Cy5 | 1 mg / 250 Euro | |||||
