11-beta HSD2 / HSD11B2 antibody
Principal name
11-beta HSD2 / HSD11B2 antibody
Alternative names for 11-beta HSD2 / HSD11B2 antibody
11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Selected pictures


SwissProt ID
O77667 (Bovin), P50168 (Sheep), P50233 (Rat), P51661 (Mouse), P51976 (Rabit), P80365 (Human)
Gene ID
3291 (HSD11B2)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Dot blot (Dot), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Frozen Sections (C)
Background of 11-beta HSD2 / HSD11B2 antibody
There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.
General readings
[1] Mune,T., Morita,H., Suzuki,T., Takahashi,Y., Isomura,Y., Tanahashi,T., Daido,H., Yamakita,N., Deguchi,T., Sasano,H.,, et al.
Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas
[2] Kajantie,E., Dunkel,L., Turpeinen,U., Stenman,U.H., Wood,P.J., Nuutila,M. and Andersson,S.
Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants
[3] Alfaidy,N., Gupta,S., DeMarco,C., Caniggia,I. and Challis,J.R., et al.
Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications
[4] Hardy,D.B. and Yang,K., et al.
The expression of 11 beta-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: effects of hypoxia
[5] Stauffer,A.T., Rochat,M.K., Dick,B., Frey,F.J. and Odermatt,A., et al.
Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor
[6] , Albiston A.L., Obeyesekere V.R., Smith R.E., Krozowski Z.S.
Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme.
[7] , Agarwal A.K., Rogerson F.M., Mune T., White P.C.
Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase.
[8] , Brown R.W., Chapman K.E., Kotelevtsev Y., Yau J.L., Lindsay R.S., Brett L., Leckie C., Murad P., Lyons V., Mullins J.J., et al.
Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2.
[9] , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
[10] , Amin H.K., Hoeppner W.
Human hydroxysteroid dehydrogenase type 2 HSD11B2.
Antibodies
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| 14192-1-AP |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Rabbit | Aff - Purified | Hu, Ms | E, WB |
0.15 ml /
€255.00
|
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| IgG | ProteinTech Group, Inc. | ||||||
+2 additional images | |||||||
| AP08502PU-N |
11-beta HSD2 / HSD11B2 (25-40) antibody | ||||||
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Rabbit | Aff - Purified | Hu, Ms, Rt | P, WB |
50 µg /
€410.00
|
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| IgG | Acris Antibodies GmbH | ||||||
| AP52107PU-N |
11-beta HSD2 / HSD11B2 (Center) antibody | ||||||
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Rabbit | Aff - Purified | Hu | F, P, WB |
0.1 mg /
€330.00
|
||
| Ig | Acris Antibodies GmbH | ||||||
+2 additional images | |||||||
| NB100-75626 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Chicken | Aff - Purified | Hu, Mky, Rt | WB |
50 µg /
€460.00
|
||
| Novus Biologicals Inc. | |||||||
| NBP1-39478 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Rabbit | Hu, Ms, Rt | C, WB |
50 µg /
€390.00
|
|||
| IgG | Novus Biologicals Inc. | ||||||
| NBP1-53163 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Rabbit | Aff - Purified | Hu, Ms, Rt | WB |
50 µg /
€390.00
|
||
| Novus Biologicals Inc. | |||||||
| GTX82463 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Chicken | Aff - Purified | Hu, Mky, Rt | WB |
50 µg /
€460.00
|
||
| GeneTex Inc. | |||||||
| GTX109786 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Rabbit | Aff - Purified | Hu | Dot |
0.1 ml /
€200.00
|
||
| GeneTex Inc. | |||||||
| H00003291-B01 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Mouse | Serum | Hu | E(detection), WB |
50 µl /
€340.00
|
||
| Abnova Taiwan Corp. | |||||||
+1 additional image | |||||||
| H00003291-B01P |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Mouse | Purified | Hu | E(detection), WB |
50 µg /
€340.00
|
||
| Abnova Taiwan Corp. | |||||||
+1 additional image | |||||||
| H00003291-D01 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Rabbit | Serum | Hu | E(detection), IP, WB |
0.1 ml /
€360.00
|
||
| Abnova Taiwan Corp. | |||||||
+1 additional image | |||||||
| H00003291-D01P |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Rabbit | Purified | Hu | E(detection), WB |
0.1 mg /
€360.00
|
||
| Abnova Taiwan Corp. | |||||||
+1 additional image | |||||||
| ARP41372_P050 |
11-beta HSD2 / HSD11B2 antibody | ||||||
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Rabbit | Aff - Purified | Bov, Hu, Ms, Por, Rb, Rt | WB |
50 µg /
€330.00
|
||
| AVIVA Systems Biology | |||||||
Proteins
| Catalog No. | Species | Pres. | Purity | Source | |||
|---|---|---|---|---|---|---|---|
| H00003291-P01-10 |
11-beta HSD2 / HSD11B2 | ||||||
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Human | Purified |
10 µg /
€350.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00003291-P01-25 |
11-beta HSD2 / HSD11B2 | ||||||
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Human | Purified |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00003291-Q01-10 |
11-beta HSD2 / HSD11B2 | ||||||
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Human | Purified |
10 µg /
€350.00
|
||||
| Abnova Taiwan Corp. | |||||||
| H00003291-Q01-25 |
11-beta HSD2 / HSD11B2 | ||||||
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Human | Purified |
25 µg /
€500.00
|
||||
| Abnova Taiwan Corp. | |||||||
Lysates
| Catalog No. | Name | ||||||
|---|---|---|---|---|---|---|---|
| H00003291-T01 |
HSD11B2 293T Cell Transient Overexpression Lysate(Denatured) | ||||||
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0.1 ml /
€240.00
|
||||||
| Abnova Taiwan Corp. | |||||||
| NBL1-11721 |
HSD11B2 Lysate | ||||||
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0.1 mg /
€370.00
|
||||||
| Novus Biologicals Inc. | |||||||
Antibody Pairs
| Catalog No. | Name | ||||||
|---|---|---|---|---|---|---|---|
| H00003291-PW1 |
HSD11B2 (Human) IP-WB Antibody Pair | ||||||
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1 set /
€710.00
|
||||||
| Abnova Taiwan Corp. | |||||||


+2 additional images








![Western Blot: HSD11B2 Lysate [NBL1-11721] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for HSD11B2.](http://m1.acris-antibodies.com/catalog/product/cache/1/small_image/50x50/9df78eab33525d08d6e5fb8d27136e95/Novus/HSD11B2 Lysate-Western Blot-NBL1-11721-img0001.jpg)