11-beta HSD2 / HSD11B2 antibody

Principal name

11-beta HSD2 / HSD11B2 antibody

Alternative names for 11-beta HSD2 / HSD11B2 antibody

11-beta-hydroxysteroid dehydrogenase 2, HSD11K, 11-DH2, Corticosteroid 11-beta-dehydrogenase isozyme 2, NAD-dependent 11-beta-hydroxysteroid dehydrogenase

Selected pictures

11-beta HSD2 / HSD11B2 antibody - 14192-1-AP 11-beta HSD2 / HSD11B2
14192-1-AP 11-beta HSD2 / HSD11B2 - Immunohistochemistry of paraffin-embedded H-kidney(glomerulus) using 14192-1-AP(HSD11B2 Antibody) at Dilution 1:50 (under 10x lens)
11-beta HSD2 / HSD11B2 antibody - 14192-1-AP 11-beta HSD2 / HSD11B2
14192-1-AP 11-beta HSD2 / HSD11B2 - Immunohistochemistry of paraffin-embedded H-kidney(glomerulus) using 14192-1-AP(HSD11B2 Antibody) at Dilution 1:50 (under 40x lens)

SwissProt ID

O77667 (Bovin), P50168 (Sheep), P50233 (Rat), P51661 (Mouse), P51976 (Rabit), P80365 (Human)

Gene ID

3291 (HSD11B2)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Por (Porcine), Rb (Rabbit), Sh (Sheep), Chimp (Chimpanzee), Mky (Monkey), Can (Canine)

Available hosts

Rabbit, Chicken, Mouse

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C), ELISA (detection) (E(detection)), Immunoprecipitation (IP), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of 11-beta HSD2 / HSD11B2 antibody

There are at least two isozymes of the corticosteroid 11-beta-dehydrogenase, a microsomal enzyme complex responsible for the interconversion of cortisol and cortisone. The type I isozyme has both 11-beta-dehydrogenase (cortisol to cortisone) and 11-oxoreductase (cortisone to cortisol) activities. The type II isozyme, encoded by this gene, has only 11-beta-dehydrogenase activity. In aldosterone-selective epithelial tissues such as the kidney, the type II isozyme catalyzes the glucocorticoid cortisol to the inactive metabolite cortisone, thus preventing illicit activation of the mineralocorticoid receptor. In tissues that do not express the mineralocorticoid receptor, such as the placenta and testis, it protects cells from the growth-inhibiting and/or pro-apoptotic effects of cortisol, particularly during embryonic development. Mutations in this gene cause the syndrome of apparent mineralocorticoid excess and hypertension.

General readings

1. Mune,T., Morita,H., Suzuki,T., Takahashi,Y., Isomura,Y., Tanahashi,T., Daido,H., Yamakita,N., Deguchi,T., Sasano,H.,, et al.
Role of local 11 beta-hydroxysteroid dehydrogenase type 2 expression in determining the phenotype of adrenal adenomas
2. Kajantie,E., Dunkel,L., Turpeinen,U., Stenman,U.H., Wood,P.J., Nuutila,M. and Andersson,S.
Placental 11 beta-hydroxysteroid dehydrogenase-2 and fetal cortisol/cortisone shuttle in small preterm infants
3. Alfaidy,N., Gupta,S., DeMarco,C., Caniggia,I. and Challis,J.R., et al.
Oxygen regulation of placental 11 beta-hydroxysteroid dehydrogenase 2: physiological and pathological implications
4. Hardy,D.B. and Yang,K., et al.
The expression of 11 beta-hydroxysteroid dehydrogenase type 2 is induced during trophoblast differentiation: effects of hypoxia
5. Stauffer,A.T., Rochat,M.K., Dick,B., Frey,F.J. and Odermatt,A., et al.
Chenodeoxycholic acid and deoxycholic acid inhibit 11 beta-hydroxysteroid dehydrogenase type 2 and cause cortisol-induced transcriptional activation of the mineralocorticoid receptor
6. , Albiston A.L., Obeyesekere V.R., Smith R.E., Krozowski Z.S.
Cloning and tissue distribution of the human 11 beta-hydroxysteroid dehydrogenase type 2 enzyme.
7. , Agarwal A.K., Rogerson F.M., Mune T., White P.C.
Gene structure and chromosomal localization of the human HSD11K gene encoding the kidney (type 2) isozyme of 11 beta-hydroxysteroid dehydrogenase.
8. , Brown R.W., Chapman K.E., Kotelevtsev Y., Yau J.L., Lindsay R.S., Brett L., Leckie C., Murad P., Lyons V., Mullins J.J., et al.
Cloning and production of antisera to human placental 11 beta-hydroxysteroid dehydrogenase type 2.
9. , Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G., Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D., Altschul S.F., et al.
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10. , Amin H.K., Hoeppner W.
Human hydroxysteroid dehydrogenase type 2 HSD11B2.

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
14192-1-AP

11-beta HSD2 / HSD11B2 antibody

Immunohistochemical of  paraffin-embedded human kidney using 14192-1-AP(HSD11B2 antibody) at dilution of 1:50 (under 10x lens) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.15 ml / €250.00
  Proteintech Group, Inc.
bs-3618R

11-beta HSD2 / HSD11B2 antibody

Formalin-fixed and paraffin embedded mouse kidney tissue labeled with Anti HSD11B2 Polyclonal Antibody, Unconjugated (bs-3618R) at 1:200 followed by conjugation to the secondary antibody and DAB staining Rabbit IgG Aff - Purified Can, Hu, Ms, Rt E, ICC/IF, P, WB
0.1 ml / €220.00
  Bioss, Inc.
AP08502PU-N

11-beta HSD2 / HSD11B2 (25-40) antibody

Kidney: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
50 µg / €380.00
  Acris Antibodies GmbH
AP52107PU-N

11-beta HSD2 / HSD11B2 (Center) antibody

HSD11B2 Antibody AP52107PU-N flow cytometric analysis of MCF-7 cells (bottom histogram) compared to a negative control cell (top histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. Rabbit Ig Aff - Purified Hu F, P, WB
0.4 ml / €340.00
  Acris Antibodies GmbH
NB100-75626

11-beta HSD2 / HSD11B2 antibody

Western Blot: E coli-derived fusion protein as test antigen. Affinity-purified IgY dilution: 1:2000, Goat anti-IgY-HRP dilution: 1:1000. Colorimetric method for signal development. ( anti-HSD11B2 ) Chicken Aff - Purified Hu, Mky, Rt WB
50 µg / €460.00
  Novus Biologicals Inc.
NBP1-39478

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Rabbit IgG Hu, Ms, Rt P, WB
50 µg / €430.00
  Novus Biologicals Inc.
NBP1-53163

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Rabbit Aff - Purified Hu, Ms, Rt WB
50 µg / €390.00
  Novus Biologicals Inc.
GTX82463

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Chicken Aff - Purified Chimp, Hu, Rt WB
50 µg / €460.00
  GeneTex Inc.
GTX109786

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Rabbit Aff - Purified Sh C, WB
0.1 ml / €320.00
  GeneTex Inc.
H00003291-B01

11-beta HSD2 / HSD11B2 antibody

Western Blot analysis of HSD11B2 expression in transfected 293T cell line (H00003291-T01) by HSD11B2 MaxPab polyclonal antibody.

Lane 1: HSD11B2 transfected lysate(44.55 KDa).
Lane 2: Non-transfected lysate.
Mouse Serum Hu E(detection), WB
50 µl / €340.00
  Abnova Taiwan Corp.
H00003291-B01P

11-beta HSD2 / HSD11B2 antibody

Western Blot analysis of HSD11B2 expression in transfected 293T cell line (H00003291-T01) by HSD11B2 MaxPab polyclonal antibody.

Lane 1: HSD11B2 transfected lysate(44.55 KDa).
Lane 2: Non-transfected lysate.
Mouse Purified Hu E(detection), WB
50 µg / €340.00
  Abnova Taiwan Corp.
H00003291-D01

11-beta HSD2 / HSD11B2 antibody

HSD11B2 MaxPab rabbit polyclonal antibody. Western Blot analysis of HSD11B2 expression in human placenta. Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €360.00
  Abnova Taiwan Corp.
H00003291-D01P

11-beta HSD2 / HSD11B2 antibody

Western Blot analysis of HSD11B2 expression in transfected 293T cell line (H00003291-T02) by HSD11B2 MaxPab polyclonal antibody.

Lane 1: HSD11B2 transfected lysate(44.10 KDa).
Lane 2: Non-transfected lysate.
Rabbit Purified Hu E(detection), WB
0.1 mg / €360.00
  Abnova Taiwan Corp.
ARP41372_P050

11-beta HSD2 / HSD11B2 antibody

11-beta HSD2 / HSD11B2 Rabbit Aff - Purified Bov, Hu, Ms, Por, Rb, Rt WB
50 µg / €330.00
  AVIVA Systems Biology

Proteins, Peptides & Growth Factors

Catalog No. Species Pres. Purity Source  
H00003291-P01-10

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €350.00
  Abnova Taiwan Corp.
H00003291-P01-25

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €500.00
  Abnova Taiwan Corp.
H00003291-Q01-10

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €350.00
  Abnova Taiwan Corp.
H00003291-Q01-25

11-beta HSD2 / HSD11B2

11-beta HSD2 / HSD11B2 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €500.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    
H00003291-T01

HSD11B2 293T Cell Transient Overexpression Lysate(Denatured)

HSD11B2 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €240.00
  Abnova Taiwan Corp.
NBL1-11721

HSD11B2 Lysate

Western Blot: HSD11B2 Lysate [NBL1-11721] - Western Blot experiments.  Left-Control; Right -Over-expression Lysate for HSD11B2.  
0.1 mg / €370.00
  Novus Biologicals Inc.

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