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14-3-3 protein epsilon antibody

Principal name

14-3-3 protein epsilon antibody

Alternative names for 14-3-3 protein epsilon antibody

14-3-3E, YWHAE, FocusOn116

Selected pictures

14-3-3 protein epsilon antibody - AP06766PU-N

AP06766PU-N - Western blot analysis of AP06766PU-N 14-3-3 ε antibody in extracts from HepG2 cells.

AP06766PU-N - Immunohistochemistry analyzes of AP06766PU-N 14-3-3 ε antibody in Paraffin-Embedded Human brain tissue.

SwissProt ID

P62258 (Human), P62259 (Mouse), P62260 (Rat), P62261 (Bovin), P62262 (Sheep), Q5ZMT0 (Chick)

Gene ID

7531 (YWHAE), 22627 (Ywhae)

Ncbi ID

9606, NP_006752.1, NP_006752, NM_009536

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Rb (Rabbit), Sh (Sheep), Can (Canine), Ze (Zebrafish), African clawed frog

Available hosts

Mouse, Rabbit, Chicken, Sheep

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Flow Cytometry (F), Frozen Sections (C)

Background of 14-3-3 protein epsilon antibody

14-3-3 proteins regulate many cellular processes relevant to cancer biology, notably apoptosis, mitogenic signaling and cell-cycle checkpoints. Seven isoforms comprise this family of signaling intermediates, denoted 14-3-3 beta, gamma, episilon, zeta, eta, theta and sigma. 14-3-3 proteins form dimers that present two binding sites for ligand proteins, thereby bringing together two proteins that may not otherwise associate. These ligands largely share a 14-3-3 consensus binding motif and exhibit serine/threonine phosphorylation. 14-3-3 proteins function in broad regulation of these ligand proteins, by cytoplasmic sequestration, occupation of interaction domains and import/export sequences, prevention of degradation, activation/repression of enzymatic activity and facilitation of protein modification, and thus loss of expression contributes to a vast array of pathogenic cellular activities.

General readings

1. Martin, H. et al. (1993) Antibodies against the major brain isoforms of 14-3-3 protein. An antibody specific for the N-acetylated amino-terminus of a protein. FEBS 331: 296-303.
2. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16: 162-172.
3. Wang, Z. et al. (2011) The prognostic value of 14-3-3 isoforms in vulvar squamous cell carcinoma cases: 14-3-3ß and e are independent prognostic factors for these tumors. PLoS One. 6: e24843.

Antibodies

Catalog No.	Host	Clone/Iso.	Pres.	React.	Applications
AP05565SU-N	14-3-3 protein epsilon (C-term) antibody
	Rabbit		Serum	Bov, Chk, Hu, Ms, Rb, Rt, Sh	E, P, WB	0.1 ml / €430.00
		IgG				Acris Antibodies GmbH

AP05568SU-N	14-3-3 protein epsilon antibody
	Rabbit		Serum	Bov, Chk, Hu, Ms, Rb, Rt, Sh	E, P, WB	0.1 ml / €430.00
		IgG				Acris Antibodies GmbH
+1 additional image

AP32388PU-N	14-3-3 protein epsilon pSer185 antibody
	Sheep		Aff - Purified	Bov, Hu, Ms, Rb, Rt, Sh	WB	0.1 ml / €340.00
		IgG				Acris Antibodies GmbH

GTX82193	14-3-3 protein epsilon antibody
	Chicken		Aff - Purified	Bov, Hu, Ms, Rt	WB	50 µg / €460.00
						GeneTex Inc.

AVARP02058_P050	14-3-3 protein epsilon antibody
	Rabbit		Aff - Purified	African clawed frog, Bov, Can, Chk, Hu, Ms, Rt, Ze	P, WB	50 µg / €330.00
						AVIVA Systems Biology