14-3-3 protein eta antibody
Principal name
14-3-3 protein eta antibody
Alternative names for 14-3-3 protein eta antibody
Protein AS1, YWHAH, YWHA1, FocusOn116
Selected pictures
Gene ID
7533 (YWHAH)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Frozen Sections (C)
Background of 14-3-3 protein eta antibody
14-3-3 eta is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isoforms and are regulated by phosphorylation of both 14-3-3 and the bound protein.
14-3-3 eta is expressed principally in the brain although it is expressed at low levels in other tissues. The protein binds alphasynuclein, forming part of lewy bodies in parkinsons disease and has been linked to earlyonset schizophrenia. The eta isoform binds both gremlin 1, which is overexpressed in human cancers, and the DAL1/Protein 4.1B tumour suppressor. Furthermore the glucocortcoid receptor is positively regulated by 14-3-3eta.
AHP1046 may not react with recombinant proteins that are not Nacetylated.
General readings
Shigeto Sato., et al. (2006), EMBO. 25, 211-221.
Chen J., et al. (2007), J Neurosci Res. 85(8):1724-33.
