14-3-3 protein theta antibody

Principal name

14-3-3 protein theta antibody

Alternative names for 14-3-3 protein theta antibody

14-3-3 protein tau, 14-3-3 protein T-cell, YWHAQ, Protein HS1

Selected pictures

14-3-3 protein theta antibody - A0758-1 14-3-3 protein theta
A0758-1 14-3-3 protein theta - Immunofluorescence analysis of HeLa cells, using 14-3-3 thet/tau (Phospho-Ser232) Antibody. The picture on the right is treated with the synthesized peptide.
14-3-3 protein theta antibody - A0758-1 14-3-3 protein theta
A0758-1 14-3-3 protein theta - Immunohistochemistry analysis of paraffin-embedded human pancreas, using 14-3-3 thet/tau (Phospho-Ser232) Antibody. The picture on the right is treated with the synthesized peptide.

SwissProt ID

P27348 (Human)

Gene ID

10971 (YWHAQ)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Rb (Rabbit), Sh (Sheep), Can (Canine), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse, Goat, Sheep

Available applications

Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Western blot / Immunoblot (WB), Immunoprecipitation (IP), Frozen Sections (C)

Background of 14-3-3 protein theta antibody

At least seven isoforms comprise the highly conserved 14-3-3 family of homo-and heterodimeric proteins that are abundantly expressed in all eukaryotic cells. These multifunctional proteins bind and modulate the function of a wide array of cellular proteins. They exist mainly as dimers with a monomeric molecular mass of approximately 30 kDa and have an acidic isoelectric point of 4.5-5. Although more than seven isoforms of 14-3-3 have been described, some redundancies have appeared upon sequencing. The 14-3-3s are thought to be key regulators of signal transduction events mediated through their binding to serine-phosphorylated proteins. By interacting with Cdc25C, 14-3-3 regulates entry into the cell cycle and through interaction with bad, prevents apoptosis.3 14-3-3 plays a dual role in Raf-1 activation. It helps to keep Raf-1 in an inactive state by binding to phophoserine-259 and the cysteine-rich domain (DRD). Interactions of 14-3-3 at the phosphoserine-621 may be required for Raf-1 activation and may function as an essential cofactor for Raf-1 kinase activity.3 Other proteins that have been shown to bind 14-3-3s include members of the protein kinase C family, Cbl, IRS-1, middle-T antigen, KSR, IGF-1 receptor, etc.3 Detection of 14-3-3 proteins in cerebrospinal fluid has been shown to be quite useful in the differential diagnosis of Creutzfeldt-Jakob disease and other prion diseases. The theta or tau isoform was initially isolated from T cells.1 It

General readings

Howlett KF, Sakamoto K, Garnham A, Cameron-Smith D, Hargreaves M.
Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle.
Diabetes. 2007 Jun;56(6):1608-14. Epub 2007 Mar 16.
PMID: 17369524

4 Item(s)

per page

Antibodies

Catalog No. Host Clone/Iso. Pres. React. Applications  
AP16695PU-N

14-3-3 protein theta antibody

Antibody (0.03µg/ml) staining of Human Brain (Hippocampus) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt WB
0.1 mg / €270.00
    Acris Antibodies GmbH
 
NBP1-06008

14-3-3 protein theta antibody

NBP1-06008 (0.03ug/ml) staining of Human Brain (Hippocampus) lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €370.00
  IgG   Novus Biologicals Inc.
 
GTX88929

14-3-3 protein theta Internal antibody

14-3-3 protein theta Goat Aff - Purified Can, Hu, Ms, Rt E, WB
0.1 mg / €330.00
  IgG   GeneTex Inc.
 
AVARP02062_P050

14-3-3 protein theta antibody

14-3-3 protein theta Rabbit Aff - Purified African clawed frog, Bov, Can, Chk, Hu, Ms, Rb, Rt, Ze P, WB
50 µg / €330.00
    AVIVA Systems Biology
 

4 Item(s)

per page
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