14-3-3 protein zeta/delta antibody

Principal name

14-3-3 protein zeta/delta antibody

Alternative names for 14-3-3 protein zeta/delta antibody

YWHAZ, KCIP-1, Protein kinase C inhibitor protein 1

Selected pictures

14-3-3 protein zeta/delta antibody - NB100-1964 14-3-3 protein beta+zeta
NB100-1964 14-3-3 protein beta+zeta - Western Blot: 14-3-3 zeta/beta Antibody (22-IID8B) [NB100-1964] - Human epidermoid carcinoma A431 cell lysate.
14-3-3 protein zeta/delta antibody - AP02457PU-S AP02457PU-N
AP02457PU-S AP02457PU-N - Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using 14-3-3 zeta (Phospho-Ser58) antibody AP02457PU.

SwissProt ID

P29361 (Sheep), P63101 (Mouse), P63102 (Rat), P63103 (Bovin), P63104 (Human), Q5ZKC9 (Chick), Q91896 (Xenla)

Gene ID

7534 (YWHAZ), 25578 (Ywhaz)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Chk (Chicken), Dros (Drosophila), African clawed frog, Ze (Zebrafish), Op (Opossum), Fe (Feline)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of 14-3-3 protein zeta/delta antibody

It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha.

General readings

Choi EK et al. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem 276:19197-204 (2001). PubMed PMID: 11278424
Celis A et al. Human proteins IEF 58 and 57a are associated with the Golgi apparatus. FEBS Lett 227:14-20 (1988). PubMed PMID: 2448165
General / background references:Aitken A et al. 14-3-3 proteins: biological function and domain structure. Biochem Soc Trans 23:605-11 (1995). PubMed PMID: 8566426
Burbelo PD & Hall A 14-3-3 proteins. Hot numbers in signal transduction. Curr Biol 5:95-6 (1995). PubMed PMID: 7743183

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