14-3-3 protein zeta/delta antibody

Principal name

14-3-3 protein zeta/delta antibody

Alternative names for 14-3-3 protein zeta/delta antibody

YWHAZ, KCIP-1, Protein kinase C inhibitor protein 1

Selected pictures

14-3-3 protein zeta/delta antibody - NB100-1964 14-3-3 protein beta+zeta
NB100-1964 14-3-3 protein beta+zeta - Western Blot: 14-3-3 zeta/beta Antibody (22-IID8B) [NB100-1964] - Human epidermoid carcinoma A431 cell lysate.
14-3-3 protein zeta/delta antibody - AP02457PU-S AP02457PU-N
AP02457PU-S AP02457PU-N - Figure 1. Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using 14-3-3 zeta (Phospho-Ser58) antibody AP02457PU.

SwissProt ID

P29361 (Sheep), P63101 (Mouse), P63102 (Rat), P63103 (Bovin), P63104 (Human), Q5ZKC9 (Chick), Q91896 (Xenla)

Gene ID

7534 (YWHAZ), 25578 (Ywhaz)

Available reactivities

Bov (Bovine), Can (Canine), Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rb (Rabbit), Rt (Rat), Sh (Sheep), Chk (Chicken), Dros (Drosophila), African clawed frog, Ze (Zebrafish), Op (Opossum), Fe (Feline)

Available hosts

Mouse, Rabbit

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), ELISA (detection) (E(detection)), Frozen Sections (C)

Background of 14-3-3 protein zeta/delta antibody

It is a member of the 14-3-3 family which consists of 30kDa proteins that are involved in multiple protein kinase signaling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 zeta is a susceptibility gene for paranoid schizophrenia and is overexpressed in the temporal cortex of cognitively impared Alzheimers patients. The protein binds yeast Sps1/Ste20-related kinase 1 (YSK1) and localizes to the golgi, possibly linking YSK1 signaling, protein transport, cell adhesion and migration. It co-localizes with epidermal growth factor receptor to the plasma membrane following epidermal growth factor signaling. The zeta isoform is involved in MAPKAPK2-mediated phosphorylation which may have a role in p38 MAPK-dependent inflammation. When bound to ADAM 22, 14-3-3 zeta is involved in cell adhesion. 14-3-3 zeta also interacts with cofilin, LIM-domain-containing protein kinase 1, protein kinase B/Akt and GPI alpha.

General readings

Choi EK et al. Calsenilin is a substrate for caspase-3 that preferentially interacts with the familial Alzheimer's disease-associated C-terminal fragment of presenilin 2. J Biol Chem 276:19197-204 (2001). PubMed PMID: 11278424
Celis A et al. Human proteins IEF 58 and 57a are associated with the Golgi apparatus. FEBS Lett 227:14-20 (1988). PubMed PMID: 2448165
General / background references:Aitken A et al. 14-3-3 proteins: biological function and domain structure. Biochem Soc Trans 23:605-11 (1995). PubMed PMID: 8566426
Burbelo PD & Hall A 14-3-3 proteins. Hot numbers in signal transduction. Curr Biol 5:95-6 (1995). PubMed PMID: 7743183

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Primary Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
AP21527PU-N

14-3-3 protein zeta/delta (200-245) antibody

Western blot analysis of 14-3-3 zeta in human brain lysate in the 1) absence, 2) presence of immunizing peptide, 3) mouse brain lysate and 4) rat brain lysate in the absence of immunizing peptide using AP21527PU-N at 2 µg/ml. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test. Rabbit Purified Bov, Can, Hu, Mky, Ms, Rt P, WB
0.1 mg / €330.00
  Acris Antibodies GmbH
AP54747SU-N

14-3-3 protein zeta/delta pSer184 antibody

14-3-3 protein zeta/delta Rabbit Serum Hu, Ms, Rt E, P, WB
0.2 ml / €380.00
  Acris Antibodies GmbH
AP55906PU-N

14-3-3 protein zeta/delta pThr232 antibody

Western blot analysis of extracts from Jurkat cells treated with UV using Phospho-14-3-3 zeta/ delta (Thr232) antibody AP55906PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 ml / €340.00
  Acris Antibodies GmbH
AP55906PU-S

14-3-3 protein zeta/delta pThr232 antibody

Western blot analysis of extracts from Jurkat cells treated with UV using Phospho-14-3-3 zeta/ delta (Thr232) antibody AP55906PU-N.The lane on the right is treated with the antigen-specific peptide. Rabbit Aff - Purified Hu, Ms, Rt WB
50 µl / €270.00
  Acris Antibodies GmbH
NB100-81766

14-3-3 protein zeta/delta pSer58 antibody

Immunohistochemistry: 14-3-3 zeta Phosphospecific Antibody [NB100-81766] - Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue, using 14-3-3 æ (Phospho-Ser58) antibody Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €340.00
  Novus Biologicals Inc.
NB100-91646

14-3-3 protein zeta/delta antibody

Western Blot: 14-3-3 zeta Antibody [NB100-91646] - Western blot (WB)   analyzes of 14-3-3 zeta (V52)  antibody in extracts from 293 cells. Rabbit IgG Aff - Purified Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 mg / €370.00
  Novus Biologicals Inc.
NB100-92268

14-3-3 protein zeta/delta antibody

Immunohistochemistry: 14-3-3 zeta/delta Antibody [NB100-92268] - Immunohistochemistry (IHC) analyzes of 14-3-3 æ/ä  (W228) antibody in paraffin-embedded human colon  carcinoma tissue. Rabbit IgG Purified Hu, Ms ICC/IF, P, WB
0.1 mg / €370.00
  Novus Biologicals Inc.
NBP1-19623

14-3-3 protein zeta/delta antibody

Immunohistochemistry: 14-3-3 zeta Antibody [NBP1-19623] -  14-3-3 zeta Antibody [NBP1-19623] - paraffin-embedded human brain tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €370.00
  Novus Biologicals Inc.
NBP1-31325

14-3-3 protein zeta/delta antibody

Immunofluorescence: 14-3-3 zeta/delta Antibody [NBP1-31325] - Immunofluorescence analysis of HeLaS3, using 14-3-3 zeta/delta antibody at 1:100 dilution. Rabbit IgG Hu ICC/IF, P, WB
0.1 ml / €390.00
  Novus Biologicals Inc.
NBP1-35259

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Hu, Ms, Rt P
7 ml / €310.00
  Novus Biologicals Inc.
NBP1-56651

14-3-3 protein zeta/delta antibody

Western Blot: 14-3-3 zeta Antibody [NBP1-56651] - This Anti-YWHAZ antibody was used in Western Blot of HepG2 tissue lysate at a concentration of 5ug/ml. Rabbit Purified Can, Hu, Ms, Rt WB
0.1 mg / €330.00
  Novus Biologicals Inc.
NBP1-56672

14-3-3 protein zeta/delta antibody

Western Blot: 14-3-3 zeta Antibody [NBP1-56672] - This Anti-YWHAZ antibody was used in Western Blot of Fetal Lung tissue lysate at a concentration of 1ug/ml. Rabbit Aff - Purified Hu, Ms, Rt P, WB
50 µg / €390.00
  Novus Biologicals Inc.
NBP1-61188-0.1

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, IP, P, WB
0.1 mg / €330.00
  Novus Biologicals Inc.
NBP1-61188-50

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, IP, P, WB
50 µg / €290.00
  Novus Biologicals Inc.
NBP1-61495-0.1

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
0.1 mg / €330.00
  Novus Biologicals Inc.
NBP1-61495-50

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Aff - Purified Hu, Ms, Rt E, ICC/IF, P, WB
50 µg / €290.00
  Novus Biologicals Inc.
NBP1-66399-0.1

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €340.00
  Novus Biologicals Inc.
NBP1-66399-50

14-3-3 protein zeta/delta antibody

14-3-3 protein zeta/delta Rabbit IgG Aff - Purified Hu, Ms, Rt E, WB
50 µg / €290.00
  Novus Biologicals Inc.
NBP1-95196

14-3-3 protein zeta/delta antibody

Western Blot: 14-3-3 zeta/delta Antibody (EPR6379) [NBP1-95196] (A) HeLa, (B) SH-SY5Y, (C) Raji, (D) HepG2, (E) C6, (F) Raw264.7, (G) PC-12, and (H) NIH/3T3 cell lysates using anti-14-3-3 zeta/delta. Rabbit EPR6379 Purified Hu, Ms, Rt WB
0.1 ml / €390.00
  Novus Biologicals Inc.
NBP1-95238

14-3-3 protein zeta/delta antibody

Western Blot: 14-3-3 Antibody (EPR6380) [NBP1-95238] (A) HeLa, (B) SH-SY5Y, (C) Raji, and (D) HepG2 cell lysates using anti-14-3-3. Rabbit EPR6380 Purified Hu, Ms, Rt WB
0.1 ml / €390.00
  Novus Biologicals Inc.

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