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17-beta-HSD1 / HSD17B1 antibody

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Principal name

17-beta-HSD1 / HSD17B1 antibody

Alternative names for 17-beta-HSD1 / HSD17B1 antibody

20 alpha-hydroxysteroid dehydrogenase, 20-alpha HSD, 17E2DH, EDH17B1, EDH17B2, EDHB17, E17KSR, Estradiol 17-beta-dehydrogenase 1, 17-beta-hydroxysteroid dehydrogenase type 1, Placental 17-beta-hydroxysteroid dehydrogenase

Selected pictures

17-beta-HSD1 / HSD17B1 antibody - H00003292-M03
H00003292-M03 - HSD17B1 monoclonal antibody (M03), clone 2E5 Western Blot analysis of HSD17B1 expression in Jurkat ( Cat # L017V1 ).
17-beta-HSD1 / HSD17B1 antibody - H00003292-M03
H00003292-M03 - Immunoperoxidase of monoclonal antibody to HSD17B1 on formalin-fixed paraffin-embedded human small Intestine. [antibody concentration 3 ug/ml]

SwissProt ID

P14061 (Human), P51656 (Mouse), P51657 (Rat)

Gene ID

3292 (HSD17B1)

Ncbi ID

9606, NP_000404, NP_000404.2

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Ms (Mouse), Por (Porcine), Rt (Rat)

Available hosts

Mouse, Rabbit

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of 17-beta-HSD1 / HSD17B1 antibody

The principal human estrogen, 17 beta-estradiol, is a potent stimulator of certain endocrine-dependent forms of breast cancer. Because human estrogenic 17 beta-hydroxysteroid dehydrogenase (HSD17B1) catalyzes the last step in the biosynthesis of 17 beta-estradiol from the less potent estrogen, estrone, it is an attractive target for the design of inhibitors of estrogen production and tumor growth (1). It is concluded that the steroid-binding site of human placental HSD17B1 contains a histidine residue which proximates the upper A-ring region of the steroid as it undergoes the reversible binding step (2). Human estrogenic HSD17B1 is an NADP(H)-preferring enzyme. It possesses 11- and 4-fold higher specificity toward NADP(H) over NAD(H) for oxidation and reduction, respectively, as demonstrated by kinetic studies (3). Defects in the conversion of androstenedione to testosterone in the fetal testes by the enzyme HSD17B1 give rise to genetic males with female external genitalia (4)

General readings

Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Lamp, M., et al. Gynecol. Endocrinol. (2010) In press  
Haller, F., et al. J. Mol. Biol. 399(2):255-267(2010)
Iwasaki, M., et al. Nutr Cancer 62(4):466-475(2010)

11 Item(s)

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11 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
AP52108PU-N

17-beta-HSD1 / HSD17B1 (C-term) antibody

Western blot analysis of HSD17B1 Antibody (C-term) Cat.-No AP52108PU-N in SK-BR-3 cell line lysates (35ug/lane). This demonstrates the HSD17B1 antibody detected the HSD17B1 protein (arrow). Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Ig   Acris Antibodies GmbH
 
NB110-57057

17-beta-HSD1 / HSD17B1 (C-term) antibody

Immunohistochemistry: HSD17B1 (C-term) Antibody (EP1682Y) [NB110-57057] - Immunohistochemical staining of paraffin-embedded human placenta using anti-HSD17B1 (cat. #110-57057). Rabbit EP1682Y Purified Hu F, ICC/IF, IP, P, WB
0.1 ml / €430.00
  IgG   Novus Biologicals Inc.
+1 additional image
 
NBP1-56295

17-beta-HSD1 / HSD17B1 antibody

Western Blot: HSD17B1 Antibody [NBP1-56295] - This Anti-HSD17B1 antibody was used in Western Blot of Jurkat tissue lysate at a concentration of 0.5ug/ml. Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €390.00
    Novus Biologicals Inc.
 
NBP1-84901

17-beta-HSD1 / HSD17B1 antibody

Immunohistochemistry-Paraffin: HSD17B1 Antibody [NBP1-84901] Immunohistochemical staining of human placenta shows strong nuclear and cytoplasmic positivity in Syncytiotrophoblasts. Rabbit Aff - Purified Hu P
0.1 ml / €360.00
  IgG   Novus Biologicals Inc.
 
H00003292-M03

17-beta-HSD1 / HSD17B1 antibody

HSD17B1 monoclonal antibody (M03), clone 2E5 Western Blot analysis of HSD17B1 expression in Jurkat ( Cat # L017V1 ). Mouse 2E5 Purified Hu E, P, WB
0.1 mg / €340.00
  IgG1   Abnova Taiwan Corp.
+1 additional image
 
H00003292-M03A

17-beta-HSD1 / HSD17B1 antibody

HSD17B1 monoclonal antibody (M03), clone 2E5 Western Blot analysis of HSD17B1 expression in Jurkat ( Cat # L017V1 ). Mouse 2E5 Ascites Hu E, WB
0.2 ml / €340.00
  IgG1   Abnova Taiwan Corp.
 
ARP41727_P050

17-beta-HSD1 / HSD17B1 antibody

17-beta-HSD1 / HSD17B1 Rabbit Aff - Purified Bov, Can, Hu, Ms, Por, Rt P, WB
50 µg / €330.00
    AVIVA Systems Biology
+1 additional image
 

Proteins

Catalog No. Species Pres. Purity   Source  
AR50925PU-N

17-beta-HSD1 / HSD17B1 (1-328, His-tag)

17-beta-HSD1 / HSD17B1 Human Purified > 90 % E. coli
0.25 mg / €730.00
  Acris Antibodies GmbH
 
AR50925PU-S

17-beta-HSD1 / HSD17B1 (1-328, His-tag)

17-beta-HSD1 / HSD17B1 Human Purified > 90 % E. coli
50 µg / €300.00
  Acris Antibodies GmbH
 
H00003292-Q01-10

17-beta-HSD1 / HSD17B1

17-beta-HSD1 / HSD17B1 Human in vitro transl.
10 µg / €350.00
  Abnova Taiwan Corp.
 
H00003292-Q01-25

17-beta-HSD1 / HSD17B1

17-beta-HSD1 / HSD17B1 Human in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.
 

11 Item(s)

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Product Type
  1. Antibodies (7)
  2. Proteins (4)
Antibody type
  1. Antibody (Ab) (7)
Clonality
  1. Polyclonal (4)
  2. Monoclonal (3)
Target
  1. 17-beta-HSD1 / HSD17B1 (11)
Property
  1. C-term (2)
Reactivity
  1. Human (Hu) (7)
  2. Bovine (Bov) (2)
  3. Canine (Can) (2)
  4. Mouse (Ms) (2)
  5. Porcine (Por) (2)
  6. Rat (Rt) (2)
Applications
  1. Western blot / Immunoblot (WB) (6)
  2. Paraffin Sections (P) (5)
  3. Enzyme Immunoassay (E) (3)
  4. Flow cytometry (F) (1)
  5. Immunocytochemistry/​Immunofluorescence (ICC/IF) (1)
  6. Immunoprecipitation (IP) (1)
Presentation
  1. Aff - Purified (4)
  2. Purified (4)
  3. Ascites (1)
Host
  1. Rabbit (5)
  2. Mouse (2)
Images
  1. 1 image (9)
Images: Applications
  1. Western blot / Immunoblot (WB) (6)
  2. Paraffin Sections (P) (4)
  3. SDS-PAGE (2)
Species (Protein)
  1. Human (4)
Source
  1. E. coli (2)
  2. in vitro transl. (2)
Manufacturer
  1. Acris Antibodies GmbH (3)
  2. Abnova Taiwan Corp. (4)
  3. Novus Biologicals Inc. (3)
  4. AVIVA Systems Biology (1)
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