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4-1BBL / TNFSF9 antibody

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Principal name

4-1BBL / TNFSF9 antibody

Alternative names for 4-1BBL / TNFSF9 antibody

4-1BB ligand, CD137L, Tumor necrosis factor ligand superfamily member 9

Selected pictures

4-1BBL / TNFSF9 antibody - NB100-77909 4-1BBL / TNFSF9
NB100-77909 4-1BBL / TNFSF9 - HuT 78 (T lymphoma cell line) stained with purified 5F4, then detected with biotinylated antimouse IgG followed by Sav-PE
4-1BBL / TNFSF9 antibody

SwissProt ID

P41273 (Human), P41274 (Mouse)

Gene ID

21950 (Tnfsf9), 8744 (TNFSF9), 3604 (TNFRSF9), 5328744 (IPR000836)

Ncbi ID

NP_033430.1, 9606, NP_003802, NP_003802.1, NM_003811

Available reactivities

Ms (Mouse), Hu (Human)

Available hosts

Rat, Mouse, Rabbit

Available applications

Immunoprecipitation (IP), Flow Cytometry (F), Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Frozen Sections (C), Neutralisation (NEUT), Paraffin Sections (P), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of 4-1BBL / TNFSF9 antibody

4-1BB ligand (4-1BBL) is a type II transmembrane glycoprotein belonging to the TNF superfamily (TNFSF) and has been designated TNFSF9. Mouse 4-1BBL cDNA encodes a 309 amino acid residues (aa) protein with an 82 aa Nterminal cytoplasmic domain, a 21 aa transmembrane domain and a 206 aa C terminal extracellular domain. The extracellular domain of 4-1BBL has a tertiary structure similar to that of other TNFSF members, but shares only low aa sequence homology (14-16%). Murine 4-1BBL shares 36% aa sequence identity with its human counterpart. 4-1BBL is predominantly expressed on activated antigen presenting cells (APCs) such as B cells, macrophages and dendritic cells (DCs). It is also expressed on most T and B lymphoma cell lines. A soluble 4-1BBL is released from the cell surface following cellular activation via proteolytic cleavage by one or more sheddases. By analogy to other TNFSF ligands, both the soluble and transmembrane 4-1BBL are expected to exist as noncovalent homotrimers. 4-1BBL binds 4-1BB, a TNF receptor superfamily member, TNFRSF9, which is also known as CD137 and ILA (induced by lymphocyte activation). 41BB is expressed on activated CD4+ and CD8+ T cells, thymocytes, and NK cells. It is also expressed on monocytes, neutrophils, DCs and eosinophils. In response to 4-1BBL binding, 4-1BB transduces a T cell costimulatory signal in both CD4+ and CD8+ T cells to promote survival and enhance proliferation, cytokine production and effector function. In dendritic cells, 4-1BB is a DC-activating molecule that enhances cytokine production and upregulates expression of B71 and B72 costimulatory molecules.

General readings

1. Goodwin, R.G. et al. (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23: 2631-41.

Items 1 to 20 of 25 total

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Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
AP20383PU-N

4-1BBL / TNFSF9 antibody

Western blot (WB) analysis of 4-1BBL pAb in extracts from HUVEC cells. Rabbit Aff - Purified Hu ICC/IF, WB
0.1 mg / €320.00
    Acris Antibodies GmbH
 
DM3534P

4-1BBL / TNFSF9 (Extracell. Dom.) antibody

4-1BBL / TNFSF9 Rat 3H19 Purified Ms F, WB
0.1 mg / €370.00
  IgG2   Acris Antibodies GmbH
 
SM2027P

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat AT113-2 Aff - Purified Ms F, IP
0.25 mg / €360.00
  IgG1   Acris Antibodies GmbH
 
SM2027PT

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat AT113-2 Purified Ms F, IP
25 µg / €140.00
  IgG1   Acris Antibodies GmbH
 
SM2027R

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat AT113-2 PE Ms F
100 Tests / €300.00
  IgG1   Acris Antibodies GmbH
 
SM2027RT

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat AT113-2 PE Ms F
25 Tests / €180.00
  IgG1   Acris Antibodies GmbH
 
NB100-77909

4-1BBL / TNFSF9 antibody

HuT 78 (T lymphoma cell line) stained with purified 5F4, then detected with biotinylated antimouse IgG followed by Sav-PE Mouse 5F4 Aff - Purified Hu F

Regular Price: 0.1 mg / €290.00

Special Price: 0.1 mg / €240.00

  IgG1   Novus Biologicals Inc.
 
NBP1-06697

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat AP-MAB0875 Purified Ms C, F, IP, NEUT, P

Regular Price: 0.5 mg / €340.00

Special Price: 0.5 mg / €280.00

  IgG2   Novus Biologicals Inc.
 
NBP1-21514

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rat RM0067-3H19 Purified Ms F, WB

Regular Price: 0.1 mg / €390.00

Special Price: 0.1 mg / €320.00

  IgG2   Novus Biologicals Inc.
 
NBP1-40426

4-1BBL / TNFSF9 antibody

Western Blot: TNFSF9 Antibody (EPR1172Y) [NBP1-40426] - Western blot analysis on 293T cell lysate using anti-4-1BBL, dilution 1:2000. Rabbit EPR1172Y Hu ICC/IF, IP, P, WB
0.1 ml / €390.00
  IgG   Novus Biologicals Inc.
 
NBP1-67930-0.1

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €340.00
  IgG   Novus Biologicals Inc.
 
NBP1-67930-50

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €290.00
  IgG   Novus Biologicals Inc.
 
GTX117355

4-1BBL / TNFSF9 antibody

Sample (30 ug of whole cell lysate) A: HCT116 12% SDS PAGE GTX17355 diluted at 1:1000 N2C3 Purified Hu WB
0.1 ml / €300.00
    GeneTex Inc.
 
H00008744-A01

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Mouse Serum Hu E, WB
50 µl / €260.00
    Abnova Taiwan Corp.
 
H00008744-M01

4-1BBL / TNFSF9 antibody

4-1BBL / TNFSF9 Mouse 1D7 Purified Hu E, WB
0.1 mg / €340.00
  IgG2a   Abnova Taiwan Corp.
 
C10600-1

4-1BBL / TNFSF9 antibody

Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
50 µg / €195.00
    Assay Biotech
+1 additional image
 
C10600-2

4-1BBL / TNFSF9 antibody

Immunofluorescence analysis of HeLa cells, using TNFSF9 Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu E, ICC/IF, WB
0.1 mg / €290.00
    Assay Biotech
+1 additional image
 
ARP61434_P050

4-1BBL / TNFSF9 (C-term) antibody

4-1BBL / TNFSF9 Rabbit Aff - Purified Hu WB
50 µg / €330.00
    AVIVA Systems Biology
 

Proteins

Catalog No. Species Pres. Purity   Source  
AR09189PU-L

4-1BBL / TNFSF9 (71-254, His-tag)

4-1BBL / TNFSF9 Human Purified > 95 % E. coli
0.5 mg / €750.00
  Acris Antibodies GmbH
+1 additional image
 
AR09189PU-N

4-1BBL / TNFSF9 (71-254, His-tag)

4-1BBL / TNFSF9 Human Purified > 95 % E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH
+1 additional image
 

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