AARS antibody

Principal name

AARS antibody

Alternative names for AARS antibody

Alanine-tRNA ligase, Renal carcinoma antigen NY-REN-42

Selected pictures

AARS antibody - 17394-1-AP AARS
17394-1-AP AARS - Immunohistochemistry of paraffin-embedded H-liver using 17394-1-AP(AARS Antibody) at Dilution 1:100 (under 10x lens)
AARS antibody - 17394-1-AP AARS
17394-1-AP AARS - Immunohistochemistry of paraffin-embedded H-liver using 17394-1-AP(AARS Antibody) at Dilution 1:100 (under 40x lens)

SwissProt ID

P49588 (Human), P50475 (Rat), Q8BGQ7 (Mouse)

Gene ID

16 (AARS)

Available reactivities

Hu (Human), Ms (Mouse), Bov (Bovine), Chk (Chicken), Rt (Rat), Ze (Zebrafish), African clawed frog

Available hosts

Rabbit, Mouse

Available applications

Enzyme Immunoassay (E), Paraffin Sections (P), Western blot / Immunoblot (WB), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP)

Background of AARS antibody

The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure.

General readings

Olsen,J.V., (2006) Cell 127 (3), 635-648

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