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ACO1 / IREB1 antibody

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Principal name

ACO1 / IREB1 antibody

Alternative names for ACO1 / IREB1 antibody

Aconitase, Iron regulatory protein 1, IRP1, , Cytoplasmic aconitate hydratase, Citrate hydro-lyase, Iron-responsive element-binding protein 1, Ferritin repressor protein

Selected pictures

ACO1 / IREB1 antibody - H00000048-M01
H00000048-M01 - Detection limit for recombinant GST tagged ACO1 is approximately 0.3ng/ml as a capture antibody.
ACO1 / IREB1 antibody - ARP40390_P050
ARP40390_P050 -

SwissProt ID

P21399 (Human), P28271 (Mouse), Q01059 (Rabit), Q0VCU1 (Bovin), Q63270 (Rat), Q90875 (Chick)

Gene ID

48 (ACO1), 3500484 (P15711)

Ncbi ID

9606, NP_002188, NP_002188.1

Available reactivities

Hu (Human), Bov (Bovine), Can (Canine), Chk (Chicken), Rb (Rabbit), Rt (Rat), African clawed frog, Ms (Mouse)

Available hosts

Mouse, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Frozen Sections (C), Immunoprecipitation (IP)

Background of ACO1 / IREB1 antibody

The insulin receptor substrate-1 (IRS-1), a major substrate of the insulin receptor, is phosphorylated in response to stimulation of cells by insulin, insulin-like growth factor 1 (IGF-1) and interleukin 4 (IL-4). IRS-1 is phosphorylated on serine, threonine and tyrosine residues in a variety of tissues. An insulin-sensitive serine/threonine kinase casein kinase II mediates a portion of the insulin-stimulated serine/threonine phosphorylation of overexpressed IRS-1 in vivo. Thr 502 is identified as the major casein kinase II-catalyzed phosphorylation site in rat IRS-1, and Ser 99 is an additional phosphorylation site catalyzed by casein kinase II. Thus, casein kinase II-catalyzed phosphorylation of IRS-1 may be a component of the intracellular insulin signaling cascade. IRS-1 contains three putative binding sites for 14-3-3 (Ser 270, Ser 374 and Ser 641) and the motif around Ser 270 is located in the phosphortyrosine binding domain of IRS-1, which is responsible for the interaction with the insulin receptor. The association of 14-3-3 with IRS-1 increases significantly upon treatment with okadaic acid, a potent serine/ threonine phosphatase inhibitor. Therefore, the association of 14-3-3 protein may play a role in the regulation of insulin sensitivity by interrupting the association between the insulin receptor and IRS-1.

General readings

Vashisht A.A., et al (2009) Science 326:718-721.
Salahudeen A.A., et al (2009) Science 326:722-726.

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42 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
12406-1-AP

ACO1 / IREB1 antibody

Mouse liver were subjected to SDS PAGE followed by western blot with 12406-1-AP(ACO1 Antibody) at dilution of 1:600 Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
 
AP20251PU-N

ACO1 / IREB1 antibody

Immunohistochemistry analyzes of IRP-1 antibody in Paraffin-Embedded Human colon carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P
0.1 mg / €320.00
    Acris Antibodies GmbH
 
AP20312PU-N

ACO1 / IREB1 antibody

Immunohistochemistry analyzes of IRP-1 antibody (AP20312PU-N) in paraffin-embedded human cervix carcinoma tissue. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €320.00
    Acris Antibodies GmbH
 
AP26015PU-N

ACO1 / IREB1 antibody

AP26015PU-N (0.1µg/ml) staining of Human Liver lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. Goat Aff - Purified Bov, Hu, Ms, Rt WB
0.1 mg / €270.00
    Acris Antibodies GmbH
 
NBP1-19412

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Aff - Purified Hu, Ms, Rt ICC/IF, P, WB
0.1 mg / €370.00
    Novus Biologicals Inc.
 
NBP1-51965

ACO1 / IREB1 antibody

ACO1 / IREB1 Goat Aff - Purified Bov, Hu, Ms, Rt E, WB
0.1 mg / €370.00
    Novus Biologicals Inc.
 
NBP1-61701-0.1

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Aff - Purified Hu, Ms, Rt C, E
0.1 mg / €340.00
  IgG   Novus Biologicals Inc.
 
NBP1-61701-50

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Aff - Purified Hu, Ms, Rt C, E
50 µg / €290.00
  IgG   Novus Biologicals Inc.
 
NBP1-61702-0.1

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Aff - Purified Hu, Ms, Rt C, E, ICC/IF
0.1 mg / €340.00
  IgG   Novus Biologicals Inc.
 
NBP1-61702-50

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Aff - Purified Hu, Ms, Rt C, E, ICC/IF
50 µg / €290.00
  IgG   Novus Biologicals Inc.
 
NBP1-87677

ACO1 / IREB1 antibody

Immunohistochemistry-Paraffin: Aconitase 1 Antibody [NBP1-87677] - Immunohistochemical staining of human kidney shows strong positivity in renal tubuli. Rabbit Aff - Purified Hu C, ICC/IF, P, WB
0.1 ml / €360.00
  IgG   Novus Biologicals Inc.
+2 additional images
 
NBP1-87678

ACO1 / IREB1 antibody

Immunohistochemistry-Paraffin: Aconitase 1 Antibody [NBP1-87678] Immunohistochemical staining of human kidney shows strong cytoplasmic positivity in tubular cells. Rabbit Aff - Purified Hu C, P
0.1 ml / €360.00
  IgG   Novus Biologicals Inc.
 
GTX102974

ACO1 / IREB1 antibody

Sample (30 ug of whole cell lysate) A: HeLa 7.5% SDS PAGE GTX102974 diluted at 1:1000 Rabbit N1C1 Purified Hu WB
0.1 ml / €300.00
  IgG   GeneTex Inc.
 
GTX102975

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Aff - Purified Hu Dot
0.1 ml / €200.00
    GeneTex Inc.
 
H00000048-B01P

ACO1 / IREB1 antibody

Western Blot analysis of ACO1 expression in transfected 293T cell line (H00000048-T01) by ACO1 MaxPab polyclonal antibody. Lane 1: ACO1 transfected lysate(97.79 KDa). Lane 2: Non-transfected lysate. Mouse Purified Hu E(detection), WB
50 µg / €340.00
    Abnova Taiwan Corp.
+1 additional image
 
H00000048-D01

ACO1 / IREB1 antibody

ACO1 / IREB1 Rabbit Serum Hu E(detection), IP, WB
0.1 ml / €360.00
    Abnova Taiwan Corp.
 
H00000048-D01P

ACO1 / IREB1 antibody

Western Blot analysis of ACO1 expression in transfected 293T cell line (H00000048-T01) by ACO1 MaxPab polyclonal antibody. Lane 1: ACO1 transfected lysate(98.40 KDa). Lane 2: Non-transfected lysate. Rabbit Purified Hu E(detection), WB
0.1 mg / €360.00
    Abnova Taiwan Corp.
+1 additional image
 
H00000048-M01

ACO1 / IREB1 antibody

Detection limit for recombinant GST tagged ACO1 is approximately 0.3ng/ml as a capture antibody. Mouse 2C1 Purified Hu E, WB
0.1 mg / €340.00
  IgG2a   Abnova Taiwan Corp.
 
H00000048-M02

ACO1 / IREB1 antibody

ACO1 / IREB1 Mouse 2F6 Purified Hu E, WB
0.1 mg / €340.00
  IgG2a   Abnova Taiwan Corp.
 
A1075-1

ACO1 / IREB1 pSer711 antibody

Immunohistochemistry analysis of paraffin-embedded human thyroid gland, using IREB1 (Phospho-Ser711) Antibody. The picture on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €195.00
    Assay Biotech
+1 additional image
 

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