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Beclin-1 antibody

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Principal name

Beclin-1 antibody

Alternative names for Beclin-1 antibody

BECN1, GT197, Coiled-coil myosin-like BCL2-interacting protein, Protein GT197

Selected pictures

Beclin-1 antibody - NB500-249 Beclin-1
NB500-249 Beclin-1 - Immunoctyochemistry: Beclin 1 Antibody [NB500-249] - Beclin 1 staining in Hela cells detected with a Dylight 488 labeled secondary antibody using NB500-249.
Beclin-1 antibody - NB500-249 Beclin-1
NB500-249 Beclin-1 - Western Blot: Beclin 1 Antibody [NB-500-249] - Detection of Beclin in mouse liver tissue lysate (50 ug) using NB 500-249. ECL detection at 1 minute.

SwissProt ID

O88597 (Mouse), Q14457 (Human), Q4A1L4 (Bovin), Q4A1L5 (Pig), Q5ZKS6 (Chick), Q91XJ1 (Rat)

Gene ID

8678 (BECN1)

Ncbi ID

9606, NP_003757.1, NP_003757, AAH10276

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Bov (Bovine), Chk (Chicken), Mky (Monkey), Por (Porcine), Xen (Xenopus), Eq (Equine), Can (Canine)

Available hosts

Rabbit, Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Paraffin Sections (P), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Frozen Sections (C), Dot blot (Dot), Flow Cytometry (F)

Background of Beclin-1 antibody

Beclin 1 is the first identified mammalian gene to mediate autophagy and also has tumor suppressor and antiviral function. Autophagy, a process of bulk protein degradation through an autophagosomic-lysosomal pathway, is important for differentiation, survival during nutrient deprivation, and normal growth control, and is often defective in tumor cells. Beclin 1 was originally isolated in a yeast two hybrid screen to identify Bcl-2-binding partners and maps to a tumor susceptibility locus on human chromosome 17q21 that is frequently monoallelically deleted in human breast, ovarian and prostate cancer. Beclin 1 encodes an evolutionarily conserved 60 kDa coiled coil protein that is expressed in human muscle, epithelial cells and neurons. In gene transfer studies, beclin 1 promotes nutrient deprivation-induced autophagy, inhibits mammary tumorigenesis, and inhibits viral replication. Expression of the Beclin 1 protein is frequently decreased in malignant breast epithelial cells. Based upon these observations, it is speculated that beclin 1 may work through induction of autophagy to negatively regulate tumorigenesis and to control viral infections. Beclin 1 may also play a role in other biological processes in which autophagy is important such as cell differentiation and nutritional stress responses.

General readings

1. Klionsky, D.J., and Emr, S. Autophagy as a regulated pathway of cellular degradation. Science. 290: 1717-1721, 2000.
2. Liang, X.H., et al. Induction of autophagy and inhibition of tumorogenesis by beclin 1. Nature. 402(6762): 672-676, 1999.
3. Aita, V.M., et al. Cloning and genomic organization of Beclin 1, a candidate tumor suppressor gene on chromosome 17q21. Genomics. 59: 59-65, 1999.
4. Liang, X.H. et al. Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein. Journal of Virology. 72(11): 8586-8596, 1998.
5.Massey, Ashish C., et al. Consequences of the selective blockage of chaperone-mediated autophagy. PNAS. 103:5805-5810, 2006 1. Personal communications with Dr. Beth Levine, Columbia University.
2. Massey, A. C., Kaushik, S., Sovak, G., Kiffin, R., and Cuervo, A. M. Consequences of the selective blockage of chaperone-mediated autophagy, 2006; 103, 5805-5810.

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63 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
11306-1-AP

Beclin-1 antibody

Immunohistochemistry of paraffin-embedded Colon cancer using 11306-1-AP(Beclin 1 Antibody) at Dilution 1:50 (under 10x lens) Rabbit Aff - Purified Hu, Ms E, P, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
+1 additional image
 
AM06595SU-N

Beclin-1 antibody

Beclin-1 Mouse 2A4 Ascites Hu E, F, P, WB
0.1 ml / €400.00
  IgG1   Acris Antibodies GmbH
+3 additional images
 
AM20210PU-N

Beclin-1 antibody

Detection of endogenous Beclin: Whole cell lysates of untreated tumor cells were applied to SDS-PAGE and transferred to a PVDF membrane. The immunoblot was probed with AM20210PU-N Beclin antibody (Clone 12B4) at 0.5 µg/ ml for 1h at RT and developed by ECL (exp. time: 30 sec). Lane 1: HeLa Lane 2: HepG2 Lane 3: HEK 293 Lane 4: SH-SY5Y Lane 5: MDCK Lane 6: PC12 Lane 7: CMT Lane 8: Neuro2A Mouse 12B4 Purified Can, Hu, Ms, Rt WB
0.1 mg / €390.00
  IgG1   Acris Antibodies GmbH
 
AM32462SU-N

Beclin-1 antibody

Breast CA section stained with Autophagy Beclin-1 antibody Cat.-No AM32462SU-N (Clone 15CT26) at 1/50 dilution. Data courtesy of Dr. Anita Thyagarajan, Cancer Research Laboratory, Methodist Research Institute, Indianapolis, Indiana. Mouse 15CT26 Ascites Hu E, P, WB
0.1 ml / €330.00
  IgG3   Acris Antibodies GmbH
+2 additional images
 
AP20054CP-N

Beclin-1 Control Peptide

Beclin-1
50 µg / €130.00
    Acris Antibodies GmbH
 
AP20054PU-N

Beclin-1 (N-term) antibody

AP20054PU-N Beclin-1 antibody staining of 293 cell lysate by Western Blotting at (A) 0.5, (B) 1 and (C) 2 μg/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €290.00
  IgG   Acris Antibodies GmbH
+1 additional image
 
AP20057CP-N

Beclin-1 Control Peptide

Beclin-1
50 µg / €130.00
    Acris Antibodies GmbH
 
AP20057PU-N

Beclin-1 (C-term) antibody

AP20057PU-N Beclin-1 antibody staining of A431 cell lysate by Western Blotting at (A) 0.5, (B) 1 and (C) 2 μg/ml. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €290.00
  IgG   Acris Antibodies GmbH
+2 additional images
 
AP22863PU-N

Beclin-1 (C-term) antibody

Western blot analysis of Beclin-1 (arrow) in A431 cell lysate with Beclin-1 antibody Cat.-No. AP22863PU-N at (A) 0.5, (B) 1 and (C) 2 µg/ml. Rabbit Purified Hu, Ms E, ICC/IF, P, WB
50 µg / €380.00
    Acris Antibodies GmbH
+4 additional images
 
AP22864PU-N

Beclin-1 (N-term) antibody

Human Heart (formalin-fixed, paraffin-embedded) stained with BECN1 antibody AP22864PU-N at 5 µg/ml followed by biotinylated goat anti-rabbit IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Rabbit Purified Hu E, P, WB
50 µg / €380.00
    Acris Antibodies GmbH
+3 additional images
 
AP30134PU-N

Beclin-1 (C-term) antibody

Western blot analysis of Beclin-1 in A431 cell lysate with AP30134PU-N Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml. Rabbit Aff - Purified Hu, Ms E, ICC/IF, WB
0.1 mg / €290.00
  IgG   Acris Antibodies GmbH
+1 additional image
 
AP30135PU-N

Beclin-1 antibody

Western blot analysis of Beclin-1 in 293 cell lysate with AP30135PU-N Beclin-1 antibody at (A) 0.5, (B) 1 and (C) 2 μg/ml. Rabbit Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €290.00
  IgG   Acris Antibodies GmbH
+1 additional image
 
NB110-55556

Beclin-1 antibody

Western Blot: Beclin-1 Antibody (EPR1733Y) [NB110-55556] - Western blot analysis on A431 cell lysate using anti-Beclin-1 (NB110-55556), dilution 1:5000. Rabbit EPR1733Y Aff - Purified Hu C, ICC/IF, IP, WB
0.1 ml / €430.00
  IgG   Novus Biologicals Inc.
+1 additional image
 
NB110-87318

Beclin-1 antibody

Immunohistochemistry: Beclin1 Antibody [NB110-87318] - Staining of breast carcinoma. Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Por, Rt, Xen ICC/IF, P, WB
50 µl / €340.00
    Novus Biologicals Inc.
+3 additional images
 
NB110-87318B

Beclin-1 antibody

Beclin-1 Rabbit Biotin Bov, Chk, Hu, Mky, Ms, Por, Rt, Xen P, WB
50 µl / €410.00
    Novus Biologicals Inc.
 
NB110-87318G

Beclin-1 antibody

Beclin-1 Rabbit DyLight488 Bov, Chk, Hu, Mky, Ms, Por, Rt, Xen P, WB
50 µl / €410.00
    Novus Biologicals Inc.
 
NB110-87318H

Beclin-1 antibody

Beclin-1 Rabbit HRP Bov, Chk, Hu, Mky, Ms, Por, Rt, Xen P, WB
50 µl / €410.00
    Novus Biologicals Inc.
 
NB110-87318SS

Beclin-1 antibody

Beclin-1 Rabbit Aff - Purified Bov, Chk, Hu, Mky, Ms, Por, Rt, Xen ICC/IF, P, WB
25 µl / €200.00
    Novus Biologicals Inc.
 
NB500-249

Beclin-1 antibody

Immunoctyochemistry: Beclin 1 Antibody [NB500-249] - Beclin 1 staining in Hela cells detected with a Dylight 488 labeled secondary antibody using NB500-249. Rabbit Aff - Purified Hu, Ms ICC/IF, IP, P, WB
0.1 ml / €340.00
    Novus Biologicals Inc.
+3 additional images
 
NB500-249B

Beclin-1 antibody

Immunohistochemistry: Beclin 1 Antibody [Biotin] [NB500-249B] - Pheochromocytes of the Adrenal Medulla 40x. Rabbit Biotin Hu, Ms IP, P, WB
0.1 ml / €410.00
    Novus Biologicals Inc.
+1 additional image
 

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