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CD40 antibody

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Principal name

CD40 antibody

Alternative names for CD40 antibody

TNFRSF5, CDw40, Bp50, , Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, CD40L receptor

Selected pictures

CD40 antibody - SM008F
SM008F - Staining of mouse spleen cells with RAT ANTI MOUSE CD40:FITC
CD40 antibody - SM008LE
SM008LE - Staining of mouse spleen with Rat Anti Mouse CD40-LOW ENDOTOXIN

SwissProt ID

P25942 (Human), P27512 (Mouse), Q28203 (Bovin), Q3ZTK5 (Horse), Q7YRL5 (Canfa), Q8SQ34 (Pig)

Gene ID

958 (CD40), 21939 (Cd40)

Ncbi ID

NP_001241.1, NP_035741.2, 9606, NP_035741, NP_001241, 10090, NP_690593

Available reactivities

Hu (Human), Mky (Monkey), Ms (Mouse), Por (Porcine), Rt (Rat), Bov (Bovine), Can (Canine), Chk (Chicken), Hst (Hamster), Rb (Rabbit), Sh (Sheep), Ge (Gerbil), Eq (Equine), Fe (Feline), Marmoset, Sq (Squirrel)

Available hosts

Mouse, Rabbit, Rat, Goat, Hamster

Available applications

Frozen Sections (C), Functional assay (FN), Flow Cytometry (F), Paraffin Sections (P), Western blot / Immunoblot (WB), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Immunocytochemistry/Immunofluorescence (ICC/IF), Dot blot (Dot), Radial Immunodiffusion (RID)

Background of CD40 antibody

CD40 and its ligand CD154 are members of the tumor necrosis factor receptor (TNFR) and TNF families, respectively, that play key roles in signaling pathways mediating cell growth, survival and differentiation in B-lymphocytes (reviewed in Quezada et al 2004). The CD40 receptor is a 45-50 kDa glycoprotein and is expressed on the surface of B-lymphocytes, some activated T-cells, monocytes, follicular dendritic cells, basal epithelial cells, and in some epithelial and non-epithelial carcinomas. The functions of CD40 have been most extensively studied in B-cells. Ligation of B CD40 by CD154, expressed on activated T cells, stimulates B cell proliferation, differentiation, isotype switching, upregulation of surface molecules contributing to antigen presentation, development of the germinal center, and the humoral memory response. Several distinct structural motifs in the CD40 cytoplasmic domain regaulate various CD40 signaling pathways. A major CD40 signaling pathway activated from CD154 ligand binding is the canonical pathway to the transcription factor family NF-kB, a family of genes mediating immune and inflammatory responses. Although CD40 has been extensively studied as a plasma membrane-associated growth factor membrane receptor. it has also been identified in the cytoplasm and nucleus of normal and neoplastic B-lymphoid cells (Lin-Lee et al. 2006). Other growth factor receptors, including EGF, FGF, and TGF-B have also been identified in the nuclus. It is thought that plasma membrane receptor signaling may be followed by nuclear migration of signaling pathway components. The presence of CD40 in the nucleus of activated normal B lymphocytes and neoplastic B-lymphoid cells suggests that CD40 may play a more complex role in regulating essential growth and survival pathways in B-lymphocytes than previously thought.

General readings

1. Oxenius A, Campbell KA, Maliszewski CR, Kishimoto T, Kikutani H, Hengartner H, Zinkernagel RM, Bachmann MF. CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functions. J Exp Med. 1996 May 1;183(5):2209-18.
2. Grewal IS, Flavell RA: The role of CD40 ligand in costimulation and T-cell activation. Immunol Rev. 1996 Oct;153:85-106.
3. Pearson LL, Castle BE, Kehry MR: CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of
mitogen-activated protein kinase signaling pathways. Int Immunol. 2001 Mar;13(3):273-83.
4. Wu W, Alexis NE, Chen X, Bromberg PA, Peden DB: Involvement of mitogen-activated protein kinases and NFkappaB in LPS-induced CD40 expression on human monocytic cells. Toxicol Appl Pharmacol. 2007 Dec 14

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Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
12971-1-AP

CD40 antibody

293 cell were subjected to SDS PAGE followed by western blot with 12971-1-AP(CD40 Antibody) at dilution of 1:800 Rabbit Aff - Purified Hu E, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
 
AM00427SU-N

CD40 antibody

Formalin-fixed, paraffin-embedded human Hodgkin’s lymphoma stained with AM00427SU-N using peroxidase-conjugate and AEC chromogen. Note membrane staining of Hodgkin’s cells and lymphocytes Mouse 11E9 Supernatant Hu P
0.5 ml / €390.00
  IgG2b   Acris Antibodies GmbH
 
AM03135AF-N

CD40 antibody

Surface staining of human peripheral blood cells with anti-human CD40 (HI40a) FITC. Cells in the lymphocyte gate were used for analysis. Mouse HI40a Azide Free Hu F
0.1 mg / €240.00
  IgG1   Acris Antibodies GmbH
 
AM03135FC-N

CD40 antibody

Surface staining of human peripheral blood cells with anti-human CD40 (HI40a) FITC. Cells in the lymphocyte gate were used for analysis. Mouse HI40a FITC Hu F
100 Tests / €240.00
  IgG1   Acris Antibodies GmbH
 
AM03135RP-N

CD40 antibody

CD40 Mouse HI40a PE Hu F
100 Tests / €280.00
  IgG1   Acris Antibodies GmbH
 
AM05671PU-N

CD40 antibody

CD40 Mouse 3B2 Purified Hu C, E, WB
0.1 mg / €400.00
  IgG1   Acris Antibodies GmbH
 
AM05685PU-N

CD40 antibody

CD40 Mouse AV79 Purified Chk F
0.25 mg / €400.00
  IgG2a   Acris Antibodies GmbH
 
AM06355SU-N

CD40 antibody

Confocal immunofluorescence analysis of human peripheral blood lymphocyles (left) and mouse L1210 cells (right) using CD40 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Mouse 9G10 Ascites Hu E, ICC/IF
0.1 ml / €370.00
  IgG1   Acris Antibodies GmbH
 
AM08042AC-N

CD40 antibody

CD40 Rat 1C10 APC Ms F
0.1 mg / €360.00
  IgG2a   Acris Antibodies GmbH
 
AM08042BT-N

CD40 antibody

CD40 Rat 1C10 Biotin Ms F
0.5 mg / €360.00
  IgG2a   Acris Antibodies GmbH
 
AM08042FC-N

CD40 antibody

Immunofluoscent Staining: Cells from BALB/c spleen were stained with Rat anti-Mouse CD40-FITC and Hamster anti CD3e-PE (clone 145-2C11), gated on small lymphocytes and analyzed on a FACScan(TM) flow cytometer (BDIS, San Jose, CA). Amount Used: 2 µg/10e6 cells. Rat 1C10 FITC Ms F
0.5 mg / €390.00
  IgG2a   Acris Antibodies GmbH
 
AM08042LE-N

CD40 antibody

CD40 Rat 1C10 Low Endotoxin Ms F, FN, IP
0.5 mg / €390.00
  IgG2a   Acris Antibodies GmbH
 
AM08042PU-N

CD40 antibody

CD40 Rat 1C10 Purified Ms F, FN, IP
0.5 mg / €310.00
  IgG2a   Acris Antibodies GmbH
 
AM08042RP-N

CD40 antibody

CD40 Rat 1C10 PE Ms F
0.2 mg / €370.00
  IgG2a   Acris Antibodies GmbH
 
AM08042RP-S

CD40 antibody

CD40 Rat 1C10 PE Ms F
0.1 mg / €250.00
  IgG2a   Acris Antibodies GmbH
 
AM08042SR-N

CD40 antibody

CD40 Rat 1C10 SPRD Ms F
0.1 mg / €380.00
  IgG2a   Acris Antibodies GmbH
 
AM08347FC-N

CD40 antibody

CD40 Mouse HB14 FITC Hu, Mky
0.5 ml / €440.00
  IgG1   Acris Antibodies GmbH
 
AM08347PU-N

CD40 antibody

AM08347PU-N at 10 µg/ml staining CD40 in Human Tonsil by Immunohistochemistry, Formalin-Fixed Paraffin-Embedded tissue. Mouse HB14 Aff - Purified Hu, Mky F, P
50 µg / €390.00
  IgG1   Acris Antibodies GmbH
 
AM08348PU-N

CD40 antibody

AM08348PU-N at 10 µg/ml staining CD40 in Human Tonsil by Immunohistochemistry, Formalin-Fixed Paraffin-Embedded tissue. Mouse G28.5 Aff - Purified Hu F, P
50 µg / €380.00
  IgG1   Acris Antibodies GmbH
 
AM31223AF-N

CD40 antibody

A typical staining pattern with the B-B20 monoclonal antibody of lymphocytes Mouse B-B20 Azide Free Hu F, FN
0.2 mg / €250.00
  IgG1   Acris Antibodies GmbH
 

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