CLEC9A antibody

Principal name

CLEC9A antibody

Alternative names for CLEC9A antibody

C-type lectin domain family 9 member A

Selected pictures

CLEC9A antibody - H00283420-B01P
H00283420-B01P - Western Blot analysis of CLEC9A expression in transfected 293T cell line (H00283420-T01) by CLEC9A MaxPab polyclonal antibody.Lane 1: CLEC9A transfected lysate(26.51 KDa).Lane 2: Non-transfected lysate.
CLEC9A antibody - AM32941PU-N CLEC9A
AM32941PU-N CLEC9A - Formalin-Fixed, Paraffin-Embedded Human breast stained with CLEC9A antibody (5 µg/ml), peroxidase-conjugate and DAB chromogen.

SwissProt ID

Q6UXN8 (Human), Q8BRU4 (Mouse)

Gene ID

283420 (CLEC9A)

Available reactivities

Hu (Human), Ms (Mouse), Chimp (Chimpanzee), Orang-Utan, Rhesus Mky (Rhesus Monkey)

Available hosts

Mouse, Rabbit

Available applications

ELISA (detection) (E(detection)), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E)

Background of CLEC9A antibody

CLEC9A is a group V CTLR (C-type lectin-like receptor) that functions as an activation receptor and is expressed on myeloid lineage cells. This protein is also expressed at the cell surface and acts as glycosylated dimers which mediate endocytosis, but not phagocytosis (Poulin LF et al, 2010). It facilitates antigen uptake and presentation, and may provide a suitable target for antibody-mediated antigen delivery. CLEC9A is important for conveying information from necrotic cells to T-cells and defines a pathway by which adaptive immune responses can be initiated in the absence of infection (Huysamen C et al, 2008). It recruits Syk to mediate sensing of necrosis by the principal DC subset involved in regulating cross priming to cell-associated antigens (Sancho D et al, 2009). Signaling via this kinase occurs through a novel pathway involving CARD9 which induce a variety of cellular responses including the induction of cytokines (such as TNF, IL-6, IL-10, IL-23, and IL-2), the respiratory burst, and the production of Arachidonic acid (Caminschi I et al, 2008). In addition, it also induces TH17 (T-helper type 17) adaptive responses in vivo. Expression of CLEC9A is highly restricted in peripheral blood, being detected only on BDCA3+ DCs and on a small subset of CD14+ CD16- monocytes. CLEC9A serves as a new marker to distinguish subtypes of DCs. Targeting antigens to DCs with antibodies to CLEC9A is a promising strategy to enhance the efficiency of vaccines, even in the absence of adjuvants (Sancho D et al, 2008).

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Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
55451-1-AP

CLEC9A antibody

Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using 55451-1-AP( CLEC9A Antibody) at dilution of 1:50 (under 10x lens) Rabbit IgG Aff - Purified Hu E, P
0.15 ml / €265.00
    ProteinTech Group, Inc.
AM32941PU-N

CLEC9A (50-100) antibody

Formalin-Fixed, Paraffin-Embedded Human breast stained with CLEC9A antibody (5 µg/ml), peroxidase-conjugate and DAB chromogen. Mouse IgG1 IMG14N8D7 Purified Chimp, Hu, Orang-Utan, Rhesus Mky P, WB
0.1 mg / €330.00
    Acris Antibodies GmbH
H00283420-B01P

CLEC9A antibody

Western Blot analysis of CLEC9A expression in transfected 293T cell line (H00283420-T01) by CLEC9A MaxPab polyclonal antibody.

Lane 1: CLEC9A transfected lysate(26.51 KDa).
Lane 2: Non-transfected lysate.
Mouse Purified Hu E(detection), WB
50 µg / €340.00
    Abnova Taiwan Corp.
H00283420-D01P

CLEC9A antibody

CLEC9A Rabbit Purified Hu, Ms E(detection), WB
0.1 mg / €360.00
    Abnova Taiwan Corp.

Proteins

Catalog No. Species Pres. Purity Source  
H00283420-P01-10

CLEC9A

CLEC9A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €350.00
  Abnova Taiwan Corp.
H00283420-P01-25

CLEC9A

CLEC9A Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €500.00
  Abnova Taiwan Corp.

Lysates

Catalog No.    
H00283420-T01

CLEC9A 293T Cell Transient Overexpression Lysate(Denatured)

CLEC9A 293T Cell Transient Overexpression Lysate(Denatured)  
0.1 ml / €240.00
  Abnova Taiwan Corp.

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