Complement C3 antibody

Principal name

Complement C3 antibody

Alternative names for Complement C3 antibody

CPAMD1, Complement component 3, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1

Selected pictures

Complement C3 antibody - CL200P Complement C3
CL200P Complement C3 -
Complement C3 antibody - NB200-540 Complement C3
NB200-540 Complement C3 - Immunofluorescence: Complement C3 Antibody (11H9) [NB200-540] - C3 protein fragments deposited on kidney cells of MPL-lpr mouse. Staining with antibody 11H9. Glomerular staining pattern.

SwissProt ID

P01024 (Human), P01025 (Pig), P01026 (Rat), P01027 (Mouse), P12247 (Rabit), P12387 (Cavpo), P23667 (Xenla), Q2UVX4 (Bovin)

Gene ID

718 (C3), 100135462, 24232, 717 (C2), 100009121, 604 (BCL6), 12266

Available reactivities

Hu (Human), Ms (Mouse), GP (Guinea Pig), Rb (Rabbit), Can (Canine), Fe (Feline), Por (Porcine), Rt (Rat), Eq (Equine), Hst (Hamster), Mky (Monkey), Bov (Bovine), Gt (Goat), Kangaroo, Mink, Sh (Sheep)

Available hosts

Chicken, Rat, Mouse, Sheep, Rabbit, Goat

Available applications

Enzyme Immunoassay (E), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Flow Cytometry (F), Paraffin Sections (P), Immunoprecipitation (IP), Immunodiffusion (ID), Radioimmunoassay (R), Dot blot (Dot)

Background of Complement C3 antibody

The monoclonal antibody 2898 recognizes the C-terminus of human complement protein C3a. The antibody recognizes intact C3, C3a as well as C3a-desArg. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. The complement system is an important part of the humoral response in innate immunity, consisting of three different pathways. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. Monoclonal antibodies detecting neo-epitopes have been used for direct quantification of activation at different steps in the complement cascade. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. In ulcerative colitis, and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by certain enzymes results in the cleavage of C3 releasing C3a anaphylatoxin and C3b. C3a is a protein of 74 amino acids. C3a itself is very short-lived and in serum is cleaved rapidly into the more stable C3a-desArg (also called acylation stimulating protein, ASP). Therefore, measurement of C3a-desArg allows reliable conclusions about the level of complement activation in the test samples. C3a is a mediator of local inflammatory processes. It induces smooth muscle contraction, increases vascular permeability, and causes histamine release from mast cells and basophilic leukocytes. C3a is involved in inflammatory reactions seen in gram-negative bacterial sepsis, trauma, ischemic heart disease, post-dialysis syndrome and a variety of autoimmune diseases.

General readings

1. Kremmer, E, Thierfelder S, Felber E, Hoffmann-Fezer, G, and Wasiliu, M. 1990. Monoclonal antibodies to complement componenets without the need of their
prior purification. II. Antibodies to mouse C3 and C4. Hybridoma. Aug; 9 (4):309-17.
2. Mastellos et al. 2004 . Novel monoclonal antibodies against C3 interfering with complement activation: description of fine specificity and applications to various
immunoassays. Molecular Immunology 40: 1213-1221.

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143 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Clone/Iso. Pres. React. Applications  
21337-1-AP

Complement C3 antibody

Human blood tissue were subjected to SDS PAGE followed by western blot with 21337-1-AP(C3 antibody) at dilution of 1:1000 Rabbit Aff - Purified Hu E, WB
0.15 ml / €265.00
  IgG   ProteinTech Group, Inc.
 
66157-1-Ig

Complement C3 antibody

Human blood tissue were subjected to SDS PAGE followed by western blot with 66157-1-Ig( C3 Antibody) at dilution of 1:1000 Mouse Purified Hu E, P, WB
0.15 ml / €265.00
  IgG1   ProteinTech Group, Inc.
 
AM05608PU-N

Complement C3 (Neoantigen, iC3b) antibody

Complement C3 Mouse 013III-1.16 Purified Hu C, E, F, WB
0.1 mg / €430.00
  IgG2b   Acris Antibodies GmbH
 
AM20720PU-N

Complement C3 antibody

Complement C3 Mouse 10A1 Purified Hu E, IP, WB
0.1 mg / €470.00
  IgG2b   Acris Antibodies GmbH
 
AM26208PU-N

Complement C3 antibody

Complement C3 Rat 4 Purified Hu IP
0.1 mg / €350.00
  IgG2a   Acris Antibodies GmbH
 
AM26209PU-N

Complement C3 antibody

Complement C3 Rat 3 Purified Hu E, IP
0.1 mg / €390.00
  IgG2a   Acris Antibodies GmbH
 
AM26224PU-N

Complement C3 antibody

Complement C3 Mouse bH6 Purified Hu C, E, P
0.1 mg / €390.00
  IgG2a   Acris Antibodies GmbH
 
AM26261PU-N

Complement C3 (C-term) antibody

Complement C3 Mouse 2898 Purified Hu E, WB
0.1 mg / €300.00
  IgG1   Acris Antibodies GmbH
 
AM26262PU-N

Complement C3 antibody

Complement C3 Mouse 2991 Purified Hu E, WB
0.1 mg / €300.00
  IgG1   Acris Antibodies GmbH
 
AM26263BT-N

Complement C3 antibody

Complement C3 Mouse 474 Biotin Hu E, WB
50 µg / €240.00
  IgG1   Acris Antibodies GmbH
 
AM26263PU-N

Complement C3 antibody

Complement C3 Mouse 474 Purified Hu E, WB
0.1 mg / €300.00
  IgG1   Acris Antibodies GmbH
 
AM26264PU-N

Complement C3 (C-term) antibody

Complement C3 Mouse 755 Purified Hu E, WB
0.1 mg / €300.00
  IgG1   Acris Antibodies GmbH
 
AM26369LE-N

Complement C3 antibody

Complement C3 Mouse 2B10B9B2 Low Endotoxin Rt E, WB
0.1 mg / €390.00
  IgM   Acris Antibodies GmbH
 
AP26371PU-N

Complement C3 antibody

Complement C3 Rabbit Purified Ms C, WB
0.1 mg / €350.00
  Ig   Acris Antibodies GmbH
 
AP31286PU-N

Complement C3 antibody

Human Liver: Formalin-Fixed, Paraffin-Embedded (FFPE). Sheep Purified Hu C, E, P
50 µl / €370.00
  IgG   Acris Antibodies GmbH
 
AP32975PU-N

Complement C3 antibody

Complement C3 Rabbit Purified Por F
0.1 mg / €350.00
  Ig   Acris Antibodies GmbH
 
CL200P

Complement C3 antibody

Complement C3 Rat RMC11H9 Purified Ms C, E, F, ICC/IF, WB
0.25 mg / €380.00
  IgG2a   Acris Antibodies GmbH
 
NB200-540

Complement C3 antibody

Immunofluorescence: Complement C3 Antibody (11H9) [NB200-540] - C3 protein fragments deposited on  kidney cells of MPL-lpr mouse. Staining with antibody 11H9. Glomerular staining pattern. Rat 11H9 Purified Ms C, E, F, ICC/IF, IP, P, WB
50 µg / €390.00
  IgG2a   Novus Biologicals Inc.
 
NB200-617

Complement C3 antibody

Complement C3 Mouse 755 Purified Hu E, WB
50 µg / €330.00
  IgG2b   Novus Biologicals Inc.
 
NB300-352

Complement C3 antibody

ELISA: C3 Antibody [NB300-352] - Human plasma C3 protein as test antigen. Affi-pure IgY as primary antibody (1.0 ug/ml), and Rabbit anti-IgY-HRP as 2nd antibody. ( anti-C3 ) Chicken Aff - Purified Hu E, WB
50 µg / €430.00
    Novus Biologicals Inc.
 

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