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Cytokeratin 7 antibody

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Principal name

Cytokeratin 7 antibody

Alternative names for Cytokeratin 7 antibody

KRT7, KRT-7, SCL, CK-7, CK7, Keratin-7, K7, K-7, Sarcolectin, Review 009, Keratin type II cytoskeletal 7

Selected pictures

Cytokeratin 7 antibody - SM3046P
SM3046P - Immunohistochemistry staining of pancreas (paraffin-embedded sections) with anti-Cytokeratin 7+17 (C-46).
Cytokeratin 7 antibody - BM6003P Cytokeratin 7
BM6003P Cytokeratin 7 - Immunohistochemistry on frozen sections of human liver (Left) and swine liver (Right), only bile duct epithelium positive; no reaction in hepatocytes. 

SwissProt ID

P08729 (Human), Q29S21 (Bovin), Q6IG12 (Rat), Q9DCV7 (Mouse)

Gene ID

3855 (KRT7), 110310 (Krt7), 54474 (KRT20)

Ncbi ID

NP_005547, NP_005547.3, NP_149064.1, 9606, NP_061883

Available reactivities

Bov (Bovine), Hu (Human), Can (Canine), Fe (Feline), Gt (Goat), Hst (Hamster), Ms (Mouse), Rt (Rat), Ze (Zebrafish), Por (Porcine), Sh (Sheep), Av (Birds)

Available hosts

Mouse, Guinea Pig, Rabbit

Available applications

Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Flow Cytometry (F), Enzyme Immunoassay (E), ELISA (detection) (E(detection))

Background of Cytokeratin 7 antibody

The cytokeratins are intermediate filament proteins responsible for the structural integrity of epithelial cells. Keratin proteins belong to 2 families: acidic (or type I) and basic (or type II). The acidic keratins are coded by genes KRT9 to 19, the basic keratins by genes KRT1 to 8. Cytokeratins 7, 17 and 19 are encoded by the genes KRT7, 17 and 19 respectively. Type I and II keratins are usually coordinately synthesized in preferential pairs so that at least 1 member of each family is expressed in each epithelial cell, in equal proportions. Cytokeratin 7 is specifically expressed in the simple epithelia lining the cavities of the internal organs and in the gland ducts and blood vessels. Cytokeratin 17 is normally expressed in the basal cells of complex epithelia (e.g. nail bed, hair follicle, sebaceous glands) but not in stratified or simple epithelia. Synthesis of cytokeratin 17 seems to be a marker of basal cell differentiation in complex epithelia. Mutations in the gene KRT17 lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. Unlike its related family members, cytokeratin 19 (the smallest known acidic cytokeratin at 40kDa) is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. It is often expressed in cultured epithelial cells and in some carcinomas.

General readings

1. Ramaekers, F., van Niekerk, C., Poels, L., Schaafsma, E., Huijsmans, A., Robben, H., Schaart, G., and Vooijs, P. (1990). Use of monoclonal antibodies to keratin 7 in the
differential diagnosis of adenocarcinomas, Am J Pathol 136, 641-55.
2. van Niekerk, C. C., Jap, P. H., Ramaekers, F. C., van de Molengraft, F., and Poels, L. G. (1991). Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues, J Pathol 165, 145-52.
3. van Niekerk, C. C., Boerman, O. C.,Ramaekers, F. C., and Poels, L. G. (1991). Marker profile of different phases in the transition of normal human ovarian epithelium to ovarian carcinomas, Am J Pathol 138, 455-63.
4. van de Molengraft, F. J., van Niekerk, C. C., Jap, P. H., and Poels, L. G. (1993). OV-TL 12/30 (keratin 7 antibody) is a marker of glandular differentiation in lung cancer,
Histopathology 22, 35-8.
5. van Niekerk, C. C., Vooijs, P., Casparie-van Velsen, I. J., and Poels, L. G. (1997). Differentiation margins of ovarian tumor pathology: first incidences of epithelial ovarian tumors monitored by marker antibodies, Cancer Detect Prev 21, 247-57.
6. Torenbeek, R., Lagendijk, J. H., Van Diest, P. J., Bril, H., van de Molengraft, F. J., and Meijer, C. J. (1998). Value of a panel of antibodies to identify the primary origin of adenocarcinomas presenting as bladder carcinoma, Histopathology 32, 20-7.

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Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
DB 051-0.1

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit R17-S Aff - Purified Hu P
0.1 ml / €270.00
  IgG   DB Biotech, spol. s r.o.
 
DB 051-0.2

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit R17-S Aff - Purified Hu P
0.2 ml / €340.00
  IgG   DB Biotech, spol. s r.o.
 
DB 051-0.5

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit R17-S Aff - Purified Hu P
0.5 ml / €440.00
  IgG   DB Biotech, spol. s r.o.
 
DB 051-1

Cytokeratin 7 (N-term) antibody

Formalin-Fixed, Paraffin-Embedded Human pancreatic tissue (4 µm) stained with anti-Cytokeratin 7 antibody (DB 051) shows positive immunostaining of pancreatic adenocarcinoma. Kindly performed and provided by Katarína Poliaková, MD and Ľubomír Straka, MD, Ph. D., from Clinical Pathology Prešov, Ltd., Prešov, Slovak republic. Rabbit R17-S Aff - Purified Hu P
1 ml / €560.00
  IgG   DB Biotech, spol. s r.o.
 
15539-1-AP

Cytokeratin 7 antibody

Immunofluorescent analysis of Hela cells, using KRT7 antibody 15539-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Rabbit Aff - Purified Hu, Ms E, P, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
+3 additional images
 
16857-1-AP

Cytokeratin 7 antibody

Immunohistochemistry of paraffin-embedded H-placenta using 16857-1-AP(KRT7-specific Antibody) at Dilution 1:100 (under 10x lens) Rabbit Aff - Purified Hu, Ms E, P, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
+2 additional images
 
17513-1-AP

Cytokeratin 7 antibody

Immunofluorescent analysis of Hela cells, using KRT7 antibody 17513-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red). Rabbit Aff - Purified Hu, Ms E, WB
0.15 ml / €255.00
  IgG   ProteinTech Group, Inc.
+3 additional images
 
AM05941FC-N

Cytokeratin 7 antibody

Cytokeratin 7 Mouse LP5K FITC Hu C, P
100 Tests / €560.00
  IgG2b   Acris Antibodies GmbH
 
AM06404SU-N

Cytokeratin 7 antibody

Western blot analysis using Cytokeratin 7 antibody Cat.-No AM06404SU-N against Hela (Lane 1), MCF-7 (Lane 2), A431 (Lane 3) and A549 (Lane 4) cell lysate. Mouse 5D12 Ascites Hu E, WB
0.1 ml / €370.00
  IgG1   Acris Antibodies GmbH
+1 additional image
 
AM08288PU-N

Cytokeratin 7 (N-term) antibody

Formalin-fixed and paraffin-embedded human pancreatic tissue (4 microns) stained with anti-Cytokeratin 7 antibody, shows positive immunostaining of pancreatic adenocarcinoma. Rabbit R17-S Purified Hu P
50 µl / €380.00
  Ig   Acris Antibodies GmbH
+1 additional image
 
AM20469SU-N

Cytokeratin 7 antibody

Placenta, Human: Formalin-Fixed, Paraffin-Embedded (FFPE) Mouse 5D12 Ascites Hu E, F, P, WB
50 µl / €380.00
  IgG1   Acris Antibodies GmbH
+4 additional images
 
AM20487PU-N

Cytokeratin 7 antibody

AM20487PU-N Cytokeratin-7 antibody staining of Formalin-Fixed, Paraffin-Embedded Human Breast at 1/50 followed by biotinylated anti-mouse IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Mouse LP5K FITC Hu C, F, ICC/IF, P, WB
25 Tests / €380.00
  IgG2b   Acris Antibodies GmbH
 
AM20610PU-N

Cytokeratin 7 antibody

Cytokeratin 7 Mouse CK-7 Purified Hu C, P, WB
0.1 mg / €340.00
  IgG1   Acris Antibodies GmbH
 
AM32076PU-N

Cytokeratin 7 (+ KRT17/19) antibody

Cytokeratin 7 Mouse 4F5 Purified Hu, Por C, WB
0.1 mg / €400.00
  IgG1   Acris Antibodies GmbH
 
AP06204PU-N

Cytokeratin 7 antibody

Immunohistochemistry analysis of Cytokeratin 7 antibody Cat.-No AP06204PU-N in paraffin-embedded human breast carcinoma tissue. Rabbit Aff - Purified Hu E, ICC/IF, P, WB
0.1 mg / €320.00
    Acris Antibodies GmbH
+1 additional image
 
AP08184PU-N

Cytokeratin 7 antibody

Adrenal: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Aff - Purified Hu P
50 µg / €380.00
  IgG   Acris Antibodies GmbH
+1 additional image
 
AP15622PU-M

Cytokeratin 7 antibody

AP15622PU Cytokeratin-7 antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P, WB
0.5 ml / €290.00
    Acris Antibodies GmbH
+1 additional image
 
AP15622PU-N

Cytokeratin 7 antibody

AP15622PU Cytokeratin-7 antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P, WB
1 ml / €400.00
    Acris Antibodies GmbH
+1 additional image
 
AP15622PU-S

Cytokeratin 7 antibody

AP15622PU Cytokeratin-7 antibody staining of Human Breast Carcinoma. Rabbit Purified Hu P, WB
0.1 ml / €170.00
    Acris Antibodies GmbH
+1 additional image
 
AP52419PU-N

Cytokeratin 7 (N-term) antibody

KRT7 Antibody (N-term) (Cat. #AP52419PU-N) western blot analysis in A549 cell line lysates (35µg/lane).This demonstrates the KRT7 antibody detected the KRT7 protein (arrow). Rabbit Aff - Purified Hu E, WB
0.1 mg / €330.00
  Ig   Acris Antibodies GmbH
 

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