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GABAA Receptor alpha 6 antibody

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Principal name

GABAA Receptor alpha 6 antibody

Alternative names for GABAA Receptor alpha 6 antibody

GABRA6, GABRA-6, Review 022, Gamma-Aminobutyric Acid Receptor subunit Alpha-6

Selected pictures

GABAA Receptor alpha 6 antibody - NB300-150 GABAA Receptor alpha 6
NB300-150 GABAA Receptor alpha 6 - Western Blot: GABA A receptor alpha 6 Antibody [NB300-150] - Western blot of rat cortex lysate showing immunolabeling of the ~57kDa alpha 6 subunit of the GABAA-R.
GABAA Receptor alpha 6 antibody - NB300-196 GABAA Receptor alpha 6
NB300-196 GABAA Receptor alpha 6 - Western Blot: GABA A Receptor alpha 6 Antibody [NB300-196] - Western blot of mouse forebrain lysates from Wild Type (Control) and a6-knockout (a6-K/O) animals showing specific immunolabeling of the ~57k a6-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a6-knockout animals.

SwissProt ID

P16305 (Mouse), P30191 (Rat), Q16445 (Human), Q90845 (Chick)

Gene ID

29708 (Gabra6), 2559 (GABRA6)

Ncbi ID

NP_068613.1, 9606, 10116, NP_000802, NP_000802.2

Available reactivities

Ms (Mouse), Rt (Rat), Bov (Bovine), Hu (Human), Can (Canine)

Available hosts

Rabbit, Goat

Available applications

Western blot / Immunoblot (WB), Immunoprecipitation (IP), Dot blot (Dot), Enzyme Immunoassay (E), Paraffin Sections (P)

Background of GABAA Receptor alpha 6 antibody

Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system. There are two major classes of GABA receptors: the GABAA and the GABAB subtype of receptors. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and sub-stance abuse. The GABAA-R is a multimeric subunit complex. To date six Alpha's, four Beta's and four Gamma's, plus alternative splicing variants of some of these subunits, have been identified (Olsen and Tobin, 1990; Whiting et al., 1999; Ogris et al., 2004). Injection in oocytes or mammalian cell lines of cRNA coding for Alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a Gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different Alpha-subunits of the receptor (McKernan et al., 2000; Mehta and Ticku, 1998; Ogris et al., 2004; Pöltl et al., 2003). Lastly, phosphorylation of Beta-subunits of the receptor has been shown to modulate GABAA-R function (Brandon et al., 2003).

General readings

1. Brandon NJ, Jovanovic JN, Colledge M, Kittler JT, Brandon JM, Scott JD, Moss SJ (2003) A kinase anchoring protein 79/150 facilitates the phosphorylation of GABAA receptors by cAMP-dependent protein kinase via selective interaction with receptor Beta--subunits. Mol Cell Neurosci 22:87-97.
2. McKernan RM, et al. (2000) Sedative but not anxiolytic properties of benzodiazepines are mediated by the GABAA receptor Alpha1-subtype. Nature Neurosci 3:587-592.
3. Mehta AK, Ticku MK (1998) Prevalence of the GABAA receptor assemblies containing Alpha-1 subunit in the rat cerebellum and cerebral cortex as determined by immunoprecipitation: Lack of modulation by chronic ethanol administration. Mol Brain Res 67:194-199.
4. Ogris W, Pöltl A, Hauer B, Ernst M, Oberto A, Wulff P, Höger H, Wisden W, Sieghart W (2004) Affinity of various benzodiazepine site ligands in mice with a point mutation in the GABAA receptor Gamma-2 subunit. Biochem Pharmacol 68:1621-1629.
5. Olsen RW, Tobin AJ (1990) Molecular biology of GABAA receptors. FASEB 4:1469-1480.
6. Pöltl A, Hauer B, Fuchs K, Tretter V, Sieghart W (2003) Subunit composition and quantitative importance of GABAA receptor subtypes in the cerebellum of mouse and rat. J Neurochem 87:1444-1455.
7. Whiting PJ, Bonnert TP, McKernan RM, Farrar S, Le Bourdellès B, Heavens RP, Smith DW, Hewson L, Rigby MR, Sirinathsinghji DJS, Thompson SA, Wafford KA (1999) Molecular and functional diversity of the expanding GABAA receptor gene family. Ann NY Acad Sci 868:645-653.

15 Item(s)

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15 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
AP05917PU-N

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Rabbit Purified Ms, Rt WB
0.1 ml / €470.00
  IgG   Acris Antibodies GmbH
 
AP08657SU-N

GABAA Receptor alpha 6 antibody

Figure 1. Western blot of rat cortex lysate showing immunolabeling of the ~57k Alpha-6 subunit of the GABAA-R. Rabbit Serum Ms, Rt WB
50 µl / €290.00
  IgG   Acris Antibodies GmbH
 
AP08658PU-N

GABAA Receptor alpha 6 antibody

Figure 1. Western blot of mouse forebrain lysates from Wild Type (Control) and Alpha-6-knockout (Alpha6-K/O) animals showing specific immunolabeling of the ~57k Alpha-6 subunit of the GABAA-R. The labeling was absent from a lysate prepared from Alpha-6-knockout animals. Rabbit Aff - Purified Bov, Hu, Ms, Rt Dot, WB
0.1 ml / €330.00
  IgG   Acris Antibodies GmbH
 
AP21175PU-N

GABAA Receptor alpha 6 antibody

Western blot (WB) analysis of GABAA Rα6 antibody (AP21175PU-N) in extracts from Jurkat cells. Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €320.00
    Acris Antibodies GmbH
 
AP22584PU-N

GABAA Receptor alpha 6 antibody

Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with GABRA6 antibody AP22584PU-N followed by biotinylated anti-goat IgG secondary antibody, alkaline phosphatase-streptavidin and chromogen. Goat Purified Bov, Can, Hu, Ms, Rt E, P, WB
50 µg / €380.00
    Acris Antibodies GmbH
+1 additional image
 
NB300-150

GABAA Receptor alpha 6 (N-term) antibody

Western Blot: GABA A receptor alpha 6 Antibody [NB300-150] - Western blot of rat cortex lysate showing immunolabeling of the ~57kDa alpha 6 subunit of the GABAA-R. Rabbit Serum Ms, Rt WB
50 µl / €340.00
    Novus Biologicals Inc.
 
NB300-196

GABAA Receptor alpha 6 antibody

Western Blot: GABA A Receptor alpha 6 Antibody [NB300-196] - Western blot of mouse forebrain lysates from Wild Type (Control) and a6-knockout (a6-K/O) animals showing specific immunolabeling of the ~57k a6-subunit of the GABAA-R. The labeling was absent from a lysate prepared from a6-knockout animals. Rabbit Purified Ms, Rt WB
0.1 ml / €340.00
    Novus Biologicals Inc.
+1 additional image
 
NBP1-68513-0.1

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €340.00
  IgG   Novus Biologicals Inc.
 
NBP1-68513-50

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €290.00
  IgG   Novus Biologicals Inc.
 
GTX31005

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Goat Aff - Purified Hu E, WB
0.1 mg / €440.00
    GeneTex Inc.
 
PAB9684

GABAA Receptor alpha 6 antibody

GABAA Receptor alpha 6 Rabbit Ms, Rt WB
0.1 ml / €350.00
    Abnova Taiwan Corp.
 
C15852-1

GABAA Receptor alpha 6 antibody

Western blot analysis of extracts from HeLa/Jurkat cells, using GABRA6 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
50 µg / €195.00
    Assay Biotech
 
C15852-2

GABAA Receptor alpha 6 antibody

Western blot analysis of extracts from HeLa/Jurkat cells, using GABRA6 Antibody. The lane on the right is treated with the synthesized peptide. Rabbit Aff - Purified Hu, Ms, Rt E, WB
0.1 mg / €290.00
    Assay Biotech
 

Proteins

Catalog No. Species Pres. Purity   Source  
H00002559-P01-10

GABAA Receptor alpha 6

GABAA Receptor alpha 6 Human Purified
10 µg / €350.00
  Abnova Taiwan Corp.
 
H00002559-P01-25

GABAA Receptor alpha 6

GABAA Receptor alpha 6 Human Purified
25 µg / €500.00
  Abnova Taiwan Corp.
 

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