MMP-8 antibody

Principal name

MMP-8 antibody

Alternative names for MMP-8 antibody

Neutrophil collagenase, Matrix metalloproteinase-8, PMNL collagenase, MMP8, CLG1, PMNL-CL

Selected pictures

MMP-8 antibody - H00004317-B01
H00004317-B01 - Western Blot analysis of MMP8 expression in transfected 293T cell line (H00004317-T01) by MMP8 MaxPab polyclonal antibody.Lane 1: MMP8 transfected lysate(51.37 KDa).Lane 2: Non-transfected lysate.
MMP-8 antibody - H00004317-B01
H00004317-B01 - MMP8 MaxPab polyclonal antibody. Western Blot analysis of MMP8 expression in human liver.

SwissProt ID

O70138 (Mouse), O88766 (Rat), P22894 (Human)

Gene ID

4317 (MMP8), 63849 (Mmp8)

Available reactivities

Hu (Human), Ms (Mouse), Rt (Rat), Mky (Monkey)

Available hosts

Mouse, Rabbit, Chicken

Available applications

Frozen Sections (C), Western blot / Immunoblot (WB), Paraffin Sections (P), Enzyme Immunoassay (E), Immunoprecipitation (IP), ELISA (detection) (E(detection)), Radial Immunodiffusion (RID), Immunocytochemistry/Immunofluorescence (ICC/IF)

Background of MMP-8 antibody

Matrix Metalloproteinase 8 (MMP8) is also known as neutrophil collagenase and collagenase 2. MMP8 degrades fibrillar collagens types I, II, III, aggrecan, serpins and alpha 2 macroglobulin. All collagenases cleave fibrillar collagens at one specific site resulting in generation of N terminal three quarter and C terminal one quarter fragments, which then denature to gelatin at body temperature. The substrate specificity of collagenases is variable: MMP1 degrades type III collagen more efficiently than type I or type II collagen, whereas MMP8 is more potent in degrading type I collagen than type III or type II collagen. MMP13, in turn degrades type II collagen 6 fold more efficiently than type I and type II collagens and displays almost 50 fold stronger gelatinolytic activity than MMP1 and MMP8. MMP8 is very similar to MMP1, sharing 57 % amino acid identity. Most cell types do not produce MMP8. Until recently, it was thought that MMP8 was produced exclusively by neutrophils, but it has also been detected in other cell types including arthritic chondrocytes and gingival fibroblasts. The human MMP8 gene has the chromosomal location of 11q22.2-22.3. MMP8 is heavily glycosylated, and the zymogen has a mass of 85 Kd. The zymogen is quickly activated to the 64 Kd form, and this breaks down to a cascade of active forms.

General readings

Van den Steen, P.E., et al., Biochem. Biophys. Res. Commun. 310(3):889-896 (2003).
Giambernardi, T.A., et al., Matrix Biol. 20(8):577-587 (2001).
Nagase, H., et al., J. Biol. Chem. 274(31):21491-21494 (1999).
Massova, I., et al., FASEB J. 12(12):1075-1095 (1998).
Pendas, A.M., et al., Genomics 37(2):266-268 (1996).

Items 1 to 20 of 52 total

per page
Page:
  1. 1
  2. 2
  3. 3
52 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
17874-1-AP

MMP-8 antibody

Immunohistochemical of  paraffin-embedded human kidney using 17874-1-AP(MMP8 antibody) at dilution of 1:100 (under 10x lens) Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.15 ml / €250.00
    ProteinTech Group, Inc.
AF8310

MMP-8 antibody

MMP-8 Mouse IgG1 115-13D2 Purified Hu C, P, WB
0.1 mg / €360.00
    Acris Antibodies GmbH
AP05868PU-N

MMP-8 (C-term) antibody

MMP-8 Rabbit IgG Purified Hu C, WB
0.1 mg / €490.00
    Acris Antibodies GmbH
AP06235PU-N

MMP-8 antibody

Western blot (WB) analysis of MMP-8 antibody (Cat.-No.: AP06235PU-N) in extracts from NIH/3T3 cells. Rabbit Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €320.00
    Acris Antibodies GmbH
AP07218PU-N

MMP-8 antibody

Heart: Formalin-Fixed Paraffin-Embedded (FFPE) Rabbit Purified Hu, Mky, Ms, Rt E, P, WB
50 µg / €380.00
    Acris Antibodies GmbH
AP13186CP-N

MMP-8 Control Peptide

MMP-8
0.1 mg / €120.00
    Acris Antibodies GmbH
AP13186PU-N

MMP-8 antibody

Western blot analysis of anti-MMP8 Pab in mouse liver tissue lysate (35ug/lane). MMP8 (arrow) was detected using the purified Pab Rabbit Ig Purified Hu, Ms E, P, WB
0.4 ml / €340.00
    Acris Antibodies GmbH
AP23348PU-N

MMP-8 (N-term) antibody

MMP8 Polyclonal Antibody
Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €340.00
    Acris Antibodies GmbH
AP26349PU-N

MMP-8 antibody

MMP-8 Rabbit Aff - Purified Hu, Ms, Rt WB
0.1 mg / €340.00
    Acris Antibodies GmbH
NB100-91880

MMP-8 antibody

Immunohistochemistry: MMP-8 Antibody [NB100-91880] - Immunohistochemistry  (IHC)  analyzes of MMP-8  (F445) antibody in paraffin-embedded human breast  carcinoma tissue. Rabbit IgG Aff - Purified Hu, Ms, Rt P, WB
0.1 mg / €370.00
    Novus Biologicals Inc.
NB110-60989

MMP-8 antibody

Immunohistochemistry-Paraffin: MMP8 Antibody (MM0023-7A11) [NB110-60989] - Human placenta (formalin fixed and paraffin embedded) section is subjected to IHC. Mouse IgG2 MM0023-7A11 Purified Hu P, WB
0.1 mg / €430.00
    Novus Biologicals Inc.
NBP1-41498

MMP-8 antibody

MMP-8 Rabbit IgG Hu, Ms, Rt P, WB
0.1 mg / €340.00
    Novus Biologicals Inc.
NBP1-67640-0.1

MMP-8 antibody

MMP-8 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
0.1 mg / €330.00
    Novus Biologicals Inc.
NBP1-67640-50

MMP-8 antibody

MMP-8 Rabbit IgG Aff - Purified Hu, Ms, Rt E, P, WB
50 µg / €290.00
    Novus Biologicals Inc.
NBP1-85576

MMP-8 antibody

Western Blot: MMP8 Antibody [NBP1-85576] Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11 | Lane 2: RT-4 | Lane 3: U-251 MG | Lane 4: Human Plasma | Lane 5: Liver | Lane 6: Tonsil Rabbit IgG Aff - Purified Hu P, WB
0.1 ml / €370.00
    Novus Biologicals Inc.
NBP1-85577

MMP-8 antibody

Immunohistochemistry-Paraffin: MMP8 Antibody [NBP1-85577] Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in subsets of cells in the red pulp. Rabbit IgG Aff - Purified Hu P
0.1 ml / €360.00
    Novus Biologicals Inc.
GTX11607

MMP-8 antibody

MMP-8 Rabbit IgG Aff - Purified Hu E, IP, P, WB
25 µg / €280.00
    GeneTex Inc.
GTX11608

MMP-8 antibody

MMP-8 Rabbit IgG Aff - Purified Hu E, IP, WB
50 µg / €320.00
    GeneTex Inc.
GTX61732

MMP-8 antibody

MMP-8 Rabbit IgG EP1252Y Supernatant Hu, Ms, Rt ICC/IF, IP, P, WB
0.1 ml / €380.00
    GeneTex Inc.
GTX82074

MMP-8 antibody

MMP-8 Chicken IgY Aff - Purified Hu WB
50 µg / €450.00
    GeneTex Inc.

Items 1 to 20 of 52 total

per page
Page:
  1. 1
  2. 2
  3. 3
  • Pinterest
  • LinkedIn