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S100A1 antibody

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Principal name

S100A1 antibody

Alternative names for S100A1 antibody

S100-A1, S100A, S100 alpha, S100 calcium-binding protein A1,S-100 protein subunit alpha,S-100 protein alpha chain, FocusOn041

Selected pictures

S100A1 antibody - SP5355P
SP5355P - Figure 1 shows a Western blot of S100-alpha from human muscle extract using S100 alpha antibody SP5355P.
S100A1 antibody - DM377 DM377-05
DM377 DM377-05 - Formalin fixed paraffin embedded human melanoma stained with S-100 antibody. DM377

SwissProt ID

P02639 (Bovin), P23297 (Human), P35467 (Rat), P56565 (Mouse), Q5RC36 (Ponab), Q7LZT1 (Misfo)

Gene ID

6271 (S100A1), 528735, 6285 (S100B), 20193 (S100a1)

Ncbi ID

NP_006262.1, NP_001092512, NP_006262, 9606, NP_006263, NP_001092512.1, NP_035439

Available reactivities

Bov (Bovine), Hu (Human), Ms (Mouse), Por (Porcine), Rt (Rat), Mam (Mammalia), Mky (Monkey), Eq (Equine), Fe (Feline), Chk (Chicken)

Available hosts

Rabbit, Mouse, Sheep

Available applications

Enzyme Immunoassay (E), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (capture) (E(capture)), ELISA (detection) (E(detection)), Frozen Sections (C), Immunocytochemistry/Immunofluorescence (ICC/IF), Radioimmunoassay (R), Flow Cytometry (F), Dot blot (Dot), Radial Immunodiffusion (RID)

Selected product citations ‐ of SP5355P

1. Boerries M, Most P, Gledhill JR, Walker JE, Katus HA, Koch WJ, et al. Ca2+ -dependent interaction of S100A1 with F1-ATPase leads to an increased ATP content in cardiomyocytes. Mol Cell Biol. 2007 Jun;27(12):4365-73. Epub 2007 Apr 16. PubMed PMID: 17438143.
2. Pleger ST, Shan C, Ksienzyk J, Bekeredjian R, Boekstegers P, Hinkel R, et al. Cardiac AAV9-S100A1 gene therapy rescues post-ischemic heart failure in a preclinical large animal model. Sci Transl Med. 2011 Jul 20;3(92):92ra64. doi: 10.1126/scitranslmed.3002097. PubMed PMID: 21775667.

Background of S100A1 antibody

S-100 protein derived from brain tissue is an acidic calcium-binding protein with molecular weight of about 21kDa. In human brain tissue S-100 protein is mainly presented as two isoforms - betabeta homodimer (S-100b) and alphabeta heterodimer (S-100a). Because of its predominant location in astroglial cells S-100 protein can be used as a sensitive and reliable marker for central nervous system injury. Structural damage of glial cells causes leakage of S-100 protein into the extracellular matrix and into cerebrospinal fluid, further releasing into the bloodstream. Measurements of S-100 protein in patient serum samples are useful in monitoring of traumatic brain injury, ischemic brain damage after circulatory arrests, and in diagnosis and prognosis of clinical outcome in acute stroke. Although predominant among the water-soluble brain proteins, S-100 is also found in a variety of other tissues. S-100 is an intracellular protein that weakly binds calcium. It binds zinc very tightly, however, and this appears to increase the affinity of the protein for calcium. Distinct binding sites, with different affinities, exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites.

General readings

General / background references:Joshi MG et al. The role of immunocytochemical markers in the differential diagnosis of proliferative and neoplastic lesions of the breast. Mod Pathol 9:57-62 (1996). McLaren KM & Cossar DW The immunohistochemical localization of S100 in the diagnosis of papillary carcinoma of the thyroid. Hum Pathol 27:633-6 (1996). Barrett AW & Scully C S100 protein in oral biology and pathology. J Oral Pathol Med 23:433-40 (1994). Matsushima S et al. S100 protein positive human breast carcinomas: an immunohistochemical study. J Surg Oncol 55:108-13 (1994).

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83 products - FILTER YOUR RESULTS!

Antibodies

Catalog No. Host Clone/Iso. Pres.   React. Applications  
AM10036FC-N

S100 antibody

S100 Mouse S100217 FITC Bov, Hu, Ms, Rt C, F, ICC/IF
0.2 mg / €330.00
  IgG1   Acris Antibodies GmbH
 
AM10036FC-S

S100 antibody

S100 Mouse S100217 FITC Bov, Hu, Mky, Ms, Rt C, F, ICC/IF, P
0.1 mg / €240.00
  IgG1   Acris Antibodies GmbH
 
AM10036PU-N

S100 antibody

S100 Mouse S100217 Purified Bov, Hu, Ms, Rt C, F, ICC/IF, P
0.2 mg / €250.00
  IgG1   Acris Antibodies GmbH
 
AM10036PU-S

S100 antibody

S100 Mouse S100217 Purified Bov, Hu, Ms, Rt C, F, ICC/IF, P
0.1 mg / €190.00
  IgG1   Acris Antibodies GmbH
 
AP08126PU-N

S100 antibody

S100 Rabbit Purified Bov, Hu, Mky, Ms, Rt C, ICC/IF, P
1 ml / €230.00
  IgG   Acris Antibodies GmbH
 
AP08126PU-S

S100 antibody

S100 Rabbit Purified Bov, Hu, Mky, Ms, Rt C, ICC/IF, P
0.5 ml / €190.00
  IgG   Acris Antibodies GmbH
 
AP15765PU-M

S100 antibody

Human melanoma stained with anti-S100 antibody Rabbit Purified Hu P
0.5 ml / €240.00
    Acris Antibodies GmbH
 
AP15765PU-N

S100 antibody

Human melanoma stained with anti-S100 antibody Rabbit Purified Hu P
1 ml / €300.00
    Acris Antibodies GmbH
 
AP15765PU-S

S100 antibody

Human melanoma stained with anti-S100 antibody Rabbit Purified Hu P
0.1 ml / €160.00
    Acris Antibodies GmbH
 
AP31045PU-N

S100 antibody

Human Brain, Cortex: Formalin-Fixed, Paraffin-Embedded. Rabbit Aff - Purified Hu P
0.25 ml / €380.00
    Acris Antibodies GmbH
 
DM377

S100 antibody

Formalin fixed paraffin embedded human melanoma stained with S-100 antibody. DM377 Mouse 4C4.9 Purified Bov, Hu, Ms, Rt P, WB
1 ml / €290.00
  IgG2a   Acris Antibodies GmbH
 
DM377-05

S100 antibody

Formalin fixed paraffin embedded human melanoma stained with S-100 antibody. DM377 Mouse 4C4.9 Purified Bov, Hu, Ms, Rt P, WB
0.5 ml / €220.00
  IgG2a   Acris Antibodies GmbH
 
GTX10203

S100 antibody

S100 Mouse 6G1 Purified Hu E, P, WB
0.1 mg / €240.00
  IgG1   GeneTex Inc.
 
GTX14849

S100 antibody

S100 Mouse 4B3 Aff - Purified Hu E, WB
0.1 mg / €270.00
  IgG2a   GeneTex Inc.
 
GTX15520

S100 antibody

S100 Rabbit Aff - Purified Hu C
1 ml / €360.00
  IgG   GeneTex Inc.
 
GTX15521

S100 antibody

S100 Rabbit Aff - Purified Hu P
7 ml / €300.00
  IgG   GeneTex Inc.
 
GTX28330

S100 antibody

S100 Mouse 8B10 Purified Hu E, P, WB
0.2 mg / €240.00
  IgG1   GeneTex Inc.
 
GTX28334

S100 antibody

S100 Mouse 3B10 Purified Hu E, WB
0.1 mg / €230.00
  IgG2a   GeneTex Inc.
 
GTX74206

S100 antibody

S100 Rabbit Bov, Hu C, P
6 ml / €450.00
    GeneTex Inc.
 
GTX74207

S100 antibody

S100 Rabbit Bov, Hu C, P
0.5 ml / €190.00
    GeneTex Inc.
 

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