SV40 Large T antigen antibody

Principal name

SV40 Large T antigen antibody

Alternative names for SV40 Large T antigen antibody

Simian virus 40, LT-AG

Selected pictures

SV40 Large T antigen antibody - AM00600PU-N
AM00600PU-N - Methanol-fixed, SV40 transformed human cell line stained with SV40 Large T Antigen (AM00600PU-N) using peroxidase-conjugate and AEC chromogen. Note nuclear staining of cultured cells.

SwissProt ID

P03070 (Sv40)

Gene ID

1489531 (P03070)

Available reactivities

Hu (Human)

Available hosts

Mouse

Available applications

Immunocytochemistry/Immunofluorescence (ICC/IF), Immunoprecipitation (IP), Western blot / Immunoblot (WB), Paraffin Sections (P), Frozen Sections (C)

Background of SV40 Large T antigen antibody

SV40, Simian Virus 40 is a polyomavirus that is found in both monkeys and humans. Like other polyomaviruses, SV40 is a DNA virus that has the potential to cause tumors. SV40 is believed to suppress the transcriptional properties of tumor-suppressing p53 in humans through the SV40 large T-antigen and SV40 small T-antigen. It is generally assumed that large T-antigen is the major protein involved in neoplastic processes and the large T-antigen predominantly exerts its effect through deregulation of tumor suppressor p53, which is responsible for initiating regulated cell death (“apoptosis”), or cell cycle arrest when a cell is damaged. A mutated p53 gene may contribute to uncontrolled cellular proliferation, leading to a tumor. The hypothesis that SV40 might cause cancer in human has been a particularly controversial area of research. Some research has suggested that SV40 is associated with brain tumors, bone cancers, non-Hodgkin lymphoma and malignant mesothelioma. SV40 may act as a cocarcinogen with crocidolite to cause mesothelioma.

5 Item(s)

per page

Antibodies

Catalog No. Host Iso. Clone Pres. React. Applications  
AM00599PU-N

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a Pab101 Purified ICC/IF, IP, WB
0.1 mg / €420.00
    Acris Antibodies GmbH
AM00600PU-N

SV40 Large T antigen (N-term) antibody

Methanol-fixed, SV40 transformed human cell line stained with SV40 Large T Antigen (AM00600PU-N) using peroxidase-conjugate and AEC chromogen. Note nuclear staining of cultured cells. Mouse IgG2a Pab108 Purified ICC/IF, IP, WB
0.1 mg / €420.00
    Acris Antibodies GmbH
AM32245SU-N

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a MRQ-4 Supernatant Hu C, P
1 ml / €770.00
    Acris Antibodies GmbH
GTX16848

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a PAb419 Aff - Purified ICC/IF, IP
0.5 ml / €330.00
    GeneTex Inc.
GTX16879

SV40 Large T antigen antibody

SV40 Large T antigen Mouse IgG2a PAb416 Aff - Purified ICC/IF, IP, WB
0.5 ml / €330.00
    GeneTex Inc.

5 Item(s)

per page
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