Zyxin antibody
Principal name
Zyxin antibody
Alternative names for Zyxin antibody
Zyxin-2, ZYX
Selected pictures
Gene ID
7791 (ZYX)
Ncbi ID
Available reactivities
Available hosts
Available applications
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection))
Background of Zyxin antibody
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
General readings
Beckerle MC Zyxin: zinc fingers at sites of cell adhesion. Bioessays. 19:949-57 (1997).
Nix DA & Beckerle MC Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol. 138:1139-47 (1997).
Macalma T et al. Molecular characterization of human zyxin. J Biol Chem. 271:31470-8 (1996).
Crawford AW & Beckerle MC Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem 266:5847-53 (1991).
Antibodies
| Catalog No. | Host | Clone/Iso. | Pres. | React. | Applications | ||
|---|---|---|---|---|---|---|---|
| AM20957PU-N |
Zyxin antibody | ||||||
 |
Mouse | 2D1 | Hu, Ms | E, P, WB |
50 µg /
€430.00
|
||
| IgG2a | Acris Antibodies GmbH | ||||||
 +2 additional images | |||||||
| NBP1-69853 |
Zyxin antibody | ||||||
 |
Mouse | 2D1 | Purified | Hu, Ms | E, P, WB |
50 µg /
€430.00
|
|
| IgG2 | Novus Biologicals Inc. | ||||||
| H00007791-A01 |
Zyxin antibody | ||||||
|
Mouse | Serum | Hu | E, WB |
50 µl /
€260.00
|
||
| Abnova Taiwan Corp. | |||||||
| H00007791-B01 |
Zyxin antibody | ||||||
 |
Mouse | Serum | Hu | E(detection), ICC/IF, WB |
50 µl /
€340.00
|
||
| Abnova Taiwan Corp. | |||||||
| +1 additional image | |||||||
| H00007791-B01P |
Zyxin antibody | ||||||
 |
Mouse | Purified | Hu | E(detection), ICC/IF, WB |
50 µg /
€340.00
|
||
| Abnova Taiwan Corp. | |||||||
| +1 additional image | |||||||
| H00007791-M01 |
Zyxin antibody | ||||||
 |
Mouse | 2C10-4A7 | Purified | Hu | E, ICC/IF, WB |
0.1 mg /
€340.00
|
|
| IgG1 | Abnova Taiwan Corp. | ||||||
| +2 additional images | |||||||
| H00007791-M02 |
Zyxin antibody | ||||||
 |
Mouse | 2D1 | Purified | Hu | E, P, WB |
0.1 mg /
€340.00
|
|
| IgG2a | Abnova Taiwan Corp. | ||||||
| +1 additional image | |||||||
