Alternative names for Zyxin antibody
Enzyme Immunoassay (E), Immunocytochemistry/Immunofluorescence (ICC/IF), Western blot / Immunoblot (WB), Paraffin Sections (P), ELISA (detection) (E(detection)), Immunoprecipitation (IP)
Background of Zyxin antibody
Focal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles. Alternative splicing results in multiple transcript variants that encode the same isoform.
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Nix DA & Beckerle MC Nuclear-cytoplasmic shuttling of the focal contact protein, zyxin: a potential mechanism for communication between sites of cell adhesion and the nucleus. J Cell Biol. 138:1139-47 (1997). PubMed PMID: 9281590
Macalma T et al. Molecular characterization of human zyxin. J Biol Chem. 271:31470-8 (1996). PubMed PMID: 8940160
Crawford AW & Beckerle MC Purification and characterization of zyxin, an 82,000-dalton component of adherens junctions. J Biol Chem 266:5847-53 (1991). PubMed PMID: 2005121