discontinued

SM7101AF647 CD283 / TLR3 antibody

See related secondary antibodies

Search for all "CD283 / TLR3"

0.1 mg / €400.00

Quick Overview

Mouse anti Canine, Human, Mouse CD283 / TLR3 40C1285.6

Product Description for CD283 / TLR3

Mouse anti Canine, Human, Mouse CD283 / TLR3 40C1285.6.
Presentation: Alexa Fluor 647
Product is tested for Immunocytochemistry/Immunofluorescence, Flow Cytometry.

Properties for CD283 / TLR3

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Toll-like receptor 3
Presentation Alexa Fluor 647
Reactivity Can, Hu, Ms
Applications F, ICC/IF
Clonality Monoclonal
Clone 40C1285.6
Host Mouse
Isotype IgG1
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O15455
Immunogen:
KLH-conjugated synthetic peptide of human TLR3
Application Flow cytometry (Cell Surface).
Flow cytometry (Intracellular): 0.5-1.0 µg/10e6 cells.
Immunoflourescence / Immunocytochemistry.
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1) and could constitute an important and unrecognized component of innate immunity in humans. The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLRs characterized so far activate the MyD88/interleukin-1 receptor-associated kinase (IRAK) signaling pathway. Ten human homologs of TLRs (TLR1-10) have been described (3). TLR3 cDNA codes for a protein with approximate molecular weight of 120 kDa (4). TLR3 has a restricted expression pattern being expressed in dendritic cells (DC) (4-6). TLR3 mRNA expression was detected by in situ hybridization in DC and lymph nodes (6). The expression of TLR3 in a single cell type may indicate a specific role for this molecule in a restricted setting.
Concentration 0.5 mg/ml
General Readings
  1. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998).
  2. Medzhitov R and Janeway CA. Cell 91: 295-298 (1997).
  3. Chuang TH and Ulevitch RJ. Biochim. Biophys. Acta 1518 (1-2): 157-161 (2001)
  4. Rock FL., Hardiman G., Timans JC., Kastelein RA. and Bazan JF. Proc. Natl. Acad. Sci. U.S.A. 95 (2), 588-593 (1998).
  5. Muzio M, Polentarutti N, Bosisio D, Prahladan MK, Mantovani A. Toll-like receptors: a growing family of immune receptors that are differentially expressed and regulated by different leukocytes. J Leukoc Biol. 2000 Apr;67(4):450-6. PubMed PMID: 10770275.
  6. Muzio M, Bosisio D, Polentarutti N, D'amico G, Stoppacciaro A, Mancinelli R, et al. Differential expression and regulation of toll-like receptors (TLR) in human leukocytes: selective expression of TLR3 in dendritic cells. J Immunol. 2000 Jun 1;164(11):5998-6004. PubMed PMID: 10820283.
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
Alexa Fluor 647
Purification:
Protein G chromatography
Buffer System:
PBS containing 0.05% BSA and 0.05% sodium azide
State:
Liquid Ig fraction
Species Reactivity
Species reactivity (tested):
Human, mouse, dog
Specificity
Specificity:
This antibody detects CD283 / TLR3.
FocusOn and Reviews
FocusOns:

Accessory Products

Proteins and/or Positive Controls

Proteins for CD283 / TLR3 (5 products)

Catalog No. Species Pres. Purity   Source  

CD283 / TLR3

CD283 / TLR3 Human Purified > 95 % pure by SDS-PAGE and HPLC analyses HEK293 cells
25 µg / €230.00
  Acris Antibodies GmbH

CD283 / TLR3

CD283 / TLR3 Human Purified > 95 % pure by SDS-PAGE and HPLC analyses HEK293 cells
5 µg / €140.00
  Acris Antibodies GmbH

CD283 / TLR3

CD283 / TLR3 Human
10 µg / €530.00
  Abnova Taiwan Corp.

CD283 / TLR3

CD283 / TLR3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €370.00
  Abnova Taiwan Corp.

CD283 / TLR3

CD283 / TLR3 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.
  • Pinterest
  • LinkedIn