discontinued

SM1827AF647 CD284 / TLR4 antibody

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0.1 mg / €400.00

Quick Overview

Rat anti Mouse CD284 / TLR4 MTS510

Product Description for CD284 / TLR4

Rat anti Mouse CD284 / TLR4 MTS510.
Presentation: Alexa Fluor 647
Product is tested for Flow Cytometry.

Properties for CD284 / TLR4

Product Category Primary Antibodies
Target Category
Quantity 0.1 mg
Synonyms Toll-like receptor 4
Presentation Alexa Fluor 647
Reactivity Ms
Applications F
Clonality Monoclonal
Clone MTS510
Host Rat
Isotype IgG2a
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Monoclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
Q9QUK6
Immunogen:
Ba/F3 cell line expressing mouse TLR4 and MD-2 (Akashi et al. 2000)
Genename:
21898
Application Flow cytometry (Cell surface): 0.5-2.0 µg/10e6 cells.
Recommended positive control: RAW, mouse peritoneal cells.
Background The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). Ten human homologs of TLRs (TLR1-10) have been described (3). Among this family of receptors, TLR2 and TLR4 have been most studied. These studies have suggested that TLR2 and TLR4 may serve as potential main mediators of LPS signaling (4,5). The mouse TLR4 cDNA codes for a protein consisting of 835 amino acids with approximate molecular weight of 90 kDa (6).
Concentration 0.5 mg/ml
General Readings
  1. Akashi S, Shimazu R, Ogata H, Nagai Y, Takeda K, Kimoto M, Miyake K. J Immunol 164(7):3471-5 (2000).
  2. Muzio M, Natoli G, Saccani S, Levrero M, and Mantovani A. J. Exp. Med. 187: 2097-2101 (1998).
  3. Medzhitov R and Janeway CA. Cell 91: 295-298 (1997).
  4. Chuang TH and Ulevitch RJ. Biochim. Biophys. Acta 1518 (1-2): 157-161 (2001).
  5. Takeuchi O., Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa K, Takeda K and Akira S. Immunity 11: 443 (1999).
  6. Poltorak A, Riccardi-Castagnoli P, Citterio S, and Butler B. Proc. Natl. Acad. Sci USA 97: 2163-2167 (2000).
  7. Medzhitov R, Preston-Hurlburt P and Janeway CA Jr. Nature 388 (6640), 394-397 (1997).
Storage Store the antibody at 2 - 8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.
Format
Label:
Alexa Fluor® 647
Alexa Fluor 647
Purification:
Protein G chromatography
Buffer System:
PBS containing 0.05% BSA and 0.05% sodium azide
State:
Liquid Ig fraction
Species Reactivity
Species reactivity (tested):
Mouse
Specificity
Specificity:
This antibody detcts CD284 / TLR4.
Gene ID 21898
FocusOn and Reviews
FocusOns:

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