discontinued

NB110-57212 MMP-1 antibody

See related secondary antibodies

Search for all "MMP-1"

0.1 ml / €380.00

Quick Overview

Rabbit anti Human MMP-1 EP1249Y

Product Description for MMP-1

Rabbit anti Human MMP-1 EP1249Y.
Presentation: Aff - Purified
Product is tested for Immunoprecipitation, Western blot / Immunoblot.

Properties for MMP-1

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms CLG, Fibroblast collagenase, Interstitial collagenase, MMP1, Matrix metalloproteinase-1
Presentation Aff - Purified
Reactivity Hu
Applications IP, WB
Clonality Monoclonal
Clone EP1249Y
Host Rabbit
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Immunogen
Swiss Prot Num:
P03956
Genename:
4312
Isotype control PP501P
Add. information Research Areas: Cancer
Application immunoprecipitation, Western Blot, Immunoprecipitation and Western Blot, immunoprecipitation 1:20, Western Blot 1:1000
Background Human interstitial collagenase (matrix metalloproteinase-1, MMP-1), an enzyme whose only known physiologic substrate has heretofore been believed to be the extracellular matrix molecule, collagen. Data indicate that matrix metalloproteinase-1 displays an expanded substrate repertoire that supports the existence of a new interface between connective tissue turnover and serine proteinase inhibitors (1). It has been shown that the MMP-1 functions as a protease agonist of Protease-activated receptors (PAR1) cleaving the receptor at the proper site to generate PAR1-dependent Ca2+ signals and migration. These results demonstrate that MMP-1 in the stromal-tumor microenvironment can alter the behavior of cancer cells through PAR1 to promote cell migration and invasion (2). It has also been suggested that increased levels of MMP-1 due to tobacco smoking plays a major role in the aging process of skin since MMP-1 degrades collagen, which accounts for at least 70% of the dry weight of dermis. Significantly more MMP-1 has been detected in the skin of smokers than non-smokers whereas no difference was seen for the tissue inhibitor of metalloproteinases 1 (TIMP-1) (3).
General Readings
  1. Desrochers PE, et al. J Clin Invest 87(6):2258-65, 1991.
  2. Boire A, et al. Cell 120(3):303-13, 2005.
  3. Lahmann C, et al. Lancet 357(9260):935-6, 2001.
Storage Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Format
Buffer System:
0.01% Sodium Azide
State:
Aff - Purified
Specificity
Specificity:
A synthetic peptide corresponding to residues on the N-term of human MMP-1 was used as an immunogen.
Species:
Human, Mouse (-), Rat (-)
Gene ID 4312
FocusOn and Reviews
Reviews:

Accessory Products

Proteins and/or Positive Controls

Proteins for MMP-1 (15 products)

Catalog No. Species Pres. Purity   Source  
AR09435PU-N

MMP-1

MMP-1 Human > 90 % pure by SDS-PAGE and HPLC analyses. E. coli
10 µg / €230.00
  Acris Antibodies GmbH
AR09435PU-S

MMP-1

MMP-1 Human > 90 % pure by SDS-PAGE and HPLC analyses. E. coli
2 µg / €140.00
  Acris Antibodies GmbH
AR51362PU-N

MMP-1 (His-tag)

MMP-1 Human Purified > 90 % by SDS - PAGE E. coli
0.5 mg / €730.00
  Acris Antibodies GmbH
AR51362PU-S

MMP-1 (His-tag)

MMP-1 Human Purified > 90 % by SDS - PAGE E. coli
0.1 mg / €300.00
  Acris Antibodies GmbH
BA440

MMP-1 (Pro)

MMP-1 Human > 98 % >95% by SDS-PAGE, essentially free of contaminating MMPs or TIMPs. Chondrocytes
5 µg / €300.00
  Acris Antibodies GmbH
GTX48397-PRO

MMP-1

MMP-1 E. coli
10 µg / €410.00
  GeneTex Inc.
GTX65175

MMP-1

MMP-1
50 µg / €920.00
  GeneTex Inc.
GTX65176

MMP-1

MMP-1
10 µg / €400.00
  GeneTex Inc.
H00004312-P01-10

MMP-1

MMP-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
10 µg / €370.00
  Abnova Taiwan Corp.
H00004312-P01-25

MMP-1

MMP-1 Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
25 µg / €500.00
  Abnova Taiwan Corp.
H00004312-Q01-10

MMP-1

MMP-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
10 µg / €370.00
  Abnova Taiwan Corp.
H00004312-Q01-25

MMP-1

MMP-1 Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
25 µg / €500.00
  Abnova Taiwan Corp.
P4249

MMP-1

MMP-1 Human
10 µg / €450.00
  Abnova Taiwan Corp.
P4919

MMP-1

MMP-1 Human
10 µg / €580.00
  Abnova Taiwan Corp.
P6072

MMP-1

MMP-1 Human
10 µg / €290.00
  Abnova Taiwan Corp.

Positive controls for MMP-1 (2 products)

Catalog No. Species Pres. Purity   Source  
H00004312-T01

MMP1 293T Cell Transient Overexpression Lysate(Denatured)

MMP1 293T Cell Transient Overexpression Lysate(Denatured)
0.1 ml / €270.00
  Abnova Taiwan Corp.
NBL1-13149

MMP1 Lysate

Western Blot: MMP1 Lysate [NBL1-13149] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for MMP1
0.1 mg / €400.00
  Novus Biologicals Inc.
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