discontinued

AP00551PU-N MMP-15 antibody

See related secondary antibodies

Search for all "MMP-15"

0.5 mg / €480.00

Quick Overview

Rabbit anti Human, Mouse MMP-15

AP00551PU-N

Product Description for MMP-15

Rabbit anti Human, Mouse MMP-15.
Presentation: Purified
Product is tested for Paraffin Sections.

Properties for MMP-15

Product Category Primary Antibodies
Target Category
Quantity 0.5 mg
Synonyms MMP15, MT-MMP 2, MT2-MMP, MT2MMP, MTMMP2, Matrix metalloproteinase-15, Membrane-type matrix metalloproteinase 2, Membrane-type-2 matrix metalloproteinase, SMCP-2
Presentation Purified
Reactivity Hu, Ms
Applications P
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer Acris Antibodies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P51511
Immunogen:
A synthetic peptide from the catalytic domain of mouse MMP-15 / MT2-MMP protein.
Genename:
4324
Remarks:
Mol. Wt. of Antigen: 62 and 68 kDa
Application Immunohistology (Formalin/Paraffin; Use at 1:25 to 1:50 for 30 min at RT; No special pretreatment is required; Recommended Positive Control: Placenta).
Background MMPs are a group of enzymes involved in matrix degradation. Of the sixteen members of matrix metalloproteinase family ten exist in soluble form whereas MT-MMPs exist as integral membrane proteins. MT1-MMP, MT2-MMP, MT3- MMP also known as MMP14, MMP15, MMP16 respectively contain a C-terminal transmembrane domain anchoring them to the cell surface. They have an 8 amino acid insert in their catalytic domain.
MT1-MMP cleaves progelatinase A (MMP-2) and progelatinase B to their active forms. MT2-MMP plays a minor role in activation of pro-MMP-2 to its active form in breast carcinomas. Coexpression of MT1-MMP and MT2-MMp in advanced stages of breast carcinomas is indicative of possible involvement of MT2-MMP in its metastsis.
Concentration 1.0 mg/ml
General Readings
  1. Sato H, et al. (1994) Nature 370: 61-65
  2. Ueno H, .(1997) Cancer Res. 57: 2055-2060.
  3. Takino T, et al. (1995) J. Biol. Chem. 270: 23013-23020.
Storage Store the antibody at 2 - 8 °C up to one month or in aliquots at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
Purification:
Protein A chromatography
Buffer System:
10 mM PBS, pH 7.4, with 0.2 % BSA & 0.09 % sodium azide.
State:
Liquid antiserum
Purified
Specificity
Specificity:
This antibody detects MMP-15.
Cellular Localization: Cell membrane and cytoplasmic
Species:
Human, Mouse.
Gene ID 4324
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Accessory Products

Proteins and/or Positive Controls

Proteins for MMP-15 (2 products)

Catalog No. Species Pres. Purity   Source  
P1807

MMP-15

MMP-15 Human
0.1 mg / €240.00
  Abnova Taiwan Corp.
P4926

MMP-15

MMP-15 Human
10 µg / €580.00
  Abnova Taiwan Corp.

Positive controls for MMP-15 (1 products)

Catalog No. Species Pres. Purity   Source  
NBL1-13154

MMP15 Lysate

Western Blot: MMP15 Lysate [NBL1-13154] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for MMP15
0.1 mg / €400.00
  Novus Biologicals Inc.
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