NB100-2140 14-3-3 Protein pan antibody

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Rabbit anti Human, Mouse, Rat 14-3-3 Protein pan

Product Description for 14-3-3 Protein pan

Rabbit anti Human, Mouse, Rat 14-3-3 Protein pan.
Presentation: Aff - Purified
Product is tested for Paraffin Sections, Immunoprecipitation, Western blot / Immunoblot.

Properties for 14-3-3 Protein pan

Product Category Primary Antibodies
Quantity 0.1 mg
Synonyms YWHA
Presentation Aff - Purified
Reactivity Hu, Ms, Rt
Applications IP, P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

Synthetic peptide mapping to the amino terminal domain of human 14-3-3.
Add. information Research Areas: Neuroscience
Application immunohistochemistry, immunoprecipitation, Western Blot, This antibody is useful for Immunohistochemistry, Immunoprecipitation and Western Blot., immunohistochemistry , immunoprecipitation , Western Blot 1/400
Background 14-3-3 family of proteins is composed of seven isotypes, beta, gamma, zeta, epsilon, tau, eta, and sigma, that play critical roles in cell signaling events that control cell cycle progression, transcriptional alterations, and apoptosis (1-4). 14-3-3 proteins were the first signaling molecules to be identified as specific phosphoserine/threonine binding proteins (1). 14-3-3 can serve as a direct regulator of its target by altering the function of the protein (3). 14-3-3 protein targets include the signalling intermediates Raf, MEKK, PI-3 kinase and IRS-1, cell cycle proteins CDK2, Wee1, and Cdc25, and apoptosis proteins BAD and ASK-1 (3,4).
Concentration 0.2 mg/ml
General Readings
  1. Yaffe MB. How do 14-3-3 proteins work?-- Gatekeeper phosphorylation and the molecular anvil hypothesis. FEBS Lett. 2002 Feb 20;513(1):53-7. PubMed PMID: 11911880.
  2. Liu MY, Cai S, Espejo A, Bedford MT, Walker CL. 14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Cancer Res. 2002 Nov 15;62(22):6475-80. PubMed PMID: 12438239.
  3. Tzivion G, Shen YH, Zhu J. 14-3-3 proteins; bringing new definitions to scaffolding. Oncogene. 2001 Oct 1;20(44):6331-8. PubMed PMID: 11607836.
  4. Fu H, Subramanian RR, Masters SC. 14-3-3 proteins: structure, function, and regulation. Annu Rev Pharmacol Toxicol. 2000;40:617-47. PubMed PMID: 10836149.
Storage Store at 4C. Do not freeze.
Immunogen affinity purified
Buffer System:
0.1% Sodium Azide
Immunogen affinity purified
Aff - Purified
Broadly reactive among the 14-3-3 family. This recognizes alpha, beta, zeta (delta) and theta 14-3-3.
Human, Mouse, Rat
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