AP05570SU-N 14-3-3 protein sigma / SFN antibody

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0.1 ml / €460.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

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Rabbit anti Bovine, Chicken, Human, Mouse, Rabbit, Rat, Sheep 14-3-3 protein sigma / SFN

AP05570SU-N

Product Description for 14-3-3 protein sigma / SFN

Rabbit anti Bovine, Chicken, Human, Mouse, Rabbit, Rat, Sheep 14-3-3 protein sigma / SFN.
Presentation: Serum
Product is tested for Western blot / Immunoblot.

Properties for 14-3-3 protein sigma / SFN

Product Category Primary Antibodies
Target Category
Quantity 0.1 ml
Synonyms Epithelial cell marker protein 1, HME1, Stratifin
Presentation Serum
Reactivity Bov, Chk, Hu, Ms, Rb, Rt, Sh
Applications WB
Clonality Polyclonal
Host Rabbit
Isotype IgG
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
O77642
Immunogen:
Synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 sigma
AA Sequence:
Ac.MERASLIQKAC
GeneID:
443032
Application Western Blot: detects a band of approximately 30kDa in HEK293 cell lysates.
Background It is a member of the 14-3-3 family which consists of 30 kDa proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein.
14-3-3 sigma is expressed mostly in epithelial cells and has been associated with cancers including breast, nasopharyngeal, endometrial adenocarcinoma, prostate, epithelial ovarian, colorectal, adenoid cystic, and papillary. 14-3-3 sigma binds c-fos activating the MAPK pathway. Sequestration of Bax by 14-3-3 sigma inhibits apoptosis whereas sequestration of 14-3-3 sigma by CARP-1 induces it. Mitosis is regulated by 14-3-3 sigma through binding keratin filaments and sequestering cyclin B1 and cdc2. p73-dependent induction of 14-3-3 sigma regulates chemo sensitivity in breast cancers with p53 mutations. In reaction to DNA damage and along with RACK1, 14-3-3 sigma targets, DeltaNp63alpha for proteasome degradation. 14-3-3 also negatively regulates both the glucocorticoid receptor and the activity of PKB/Akt which stabilizes p27 Kip1.
Caution (A full Health and Safety assessment is available upon request) This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
General Readings
  1. Aitken, A. et al. (2006) 14-3-3 proteins: A historic overview. Seminars in Cancer Biology 16:162 - 172.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
State:
Liquid serum containing 0.09% Sodium Azide (NaN3)
Serum
Specificity
Specificity:
This antibody recognises 14-3-3 sigma in all mammals.
This antibody may not react with recombinant proteins that are not N-acetylated.
Species:
Sheep, Human, Bovine, Chicken, Rat, Mouse, Rabbit.
Gene ID 443032
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