AP22876SU-N 14-3-3 protein sigma / SFN (N-term) antibody

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50 µl / €420.00
Please visit the country specific website of OriGene Technologies or contact your local Distributor to buy this product.

Quick Overview

Rabbit anti Bovine, Chicken, Human, Mouse, Rabbit, Rat, Sheep 14-3-3 protein sigma / SFN

Product Description for 14-3-3 protein sigma / SFN

Rabbit anti Bovine, Chicken, Human, Mouse, Rabbit, Rat, Sheep 14-3-3 protein sigma / SFN.
Properties: (N-term)
Presentation: Serum
Product is tested for Paraffin Sections, Western blot / Immunoblot.

Properties for 14-3-3 protein sigma / SFN

Product Category Primary Antibodies
Target Category
Quantity 50 µl
Synonyms Epithelial cell marker protein 1, HME1, Stratifin
Presentation Serum
Reactivity Bov, Chk, Hu, Ms, Rb, Rt, Sh
Applications P, WB
Clonality Polyclonal
Host Rabbit
Shipping to Worldwide
PDF datasheet View Datasheet
Manufacturer OriGene Technologies GmbH
Material safety datasheet MSDS for Polyclonal Antibodies (de)

Datasheet Extract

Immunogen
Swiss Prot Num:
P31947
Immunogen:
SFN antibody was raised against synthetic peptide corresponding to acetylated N-terminal sequence of sheep 14-3-3 sigma.
AA Sequence:
Ac.MERASLIQKAC
GeneID:
2810
Property N-term
Application Immunohistochemistry on Paraffin Sections: 1/250.
Western Blot.
Background It is a member of the 14-3-3 family which consists of 30 kD proteins that are involved in multiple protein kinase signalling pathways, regulation of cell cycle progression, cytoskeletal structure, transcription, intracellular trafficking and targeting. Protein interactions with 14-3-3 show distinct preference for its different isotypes and are regulated by phosphorylation of both 14-3-3 and the bound protein. 14-3-3 sigma is expressed mostly in epithelial cells and has been associated with cancers including breast, nasopharyngeal, endometrial adenocarcinoma, prostate, epithelial ovarian, colorectal, adenoid cystic, and papillary. 14-3-3 sigma binds c-fos activating the MAPK pathway. Sequestration of Bax by 14-3-3 sigma inhibits apoptosis whereas sequestration of 14-3-3 sigma by CARP-1 induces it. Mitosis is regulated by 14-3-3 sigma through binding keratin filaments and sequestering cyclin B1 and cdc2. p73-dependent induction of 14-3-3 sigma regulates chemo sensitivity in breast cancers with p53 mutations. In reaction to DNA damage and along with RACK1, 14-3-3 sigma targets, DeltaNp63alpha for proteasome degradation. 14-3-3 also negatively regulates both the glucocorticoid receptor and the activity of PKB/Akt which stabilizes p27 Kip1.
Storage Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Avoid repeated freezing and thawing.
Shelf life: one year from despatch.
Format
State:
Liquid serum containing 0.09% sodium azide as preservative
Serum
Species Reactivity
Species reactivity (expected):
Human, Mouse, Rat, Rabbit, Bovine and Chicken.
Species reactivity (tested):
Sheep.
Specificity
Specificity:
This antibody reacts to 14-3-3 Protein Sigma (SFN) in all mammals. May not react with recombinant proteins that are not N-acetylated.
Gene ID 2810

Accessory Products

Proteins and/or Positive Controls

Proteins for 14-3-3 protein sigma / SFN (11 products)

Catalog No. Species Pres. Purity   Source  

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human > 80 %
Preparation: Recombint protein was captured through anti-DDK affinity column followed by conventiol chromatography steps.
Purity Detail: > 80% as determined by SDS-PAGE and Coomassie blue staining.
HEK293 cells
20 µg / €438.00
  OriGene Technologies, Inc.

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human > 95 %
Preparation: .
Purity Detail: >95% as determined by SDS-PAGE and Coomassie blue staining.
E. coli
10 µg / €299.00
  OriGene Technologies, Inc.

14-3-3 protein sigma / SFN (1-248)

14-3-3 protein sigma / SFN Human Purified > 95 % by SDS - PAGE E. coli
0.5 mg / €670.00
  OriGene Technologies GmbH

14-3-3 protein sigma / SFN (1-248)

14-3-3 protein sigma / SFN Human Purified > 95 % by SDS - PAGE E. coli
0.1 mg / €250.00
  OriGene Technologies GmbH

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human 12.5% SDS-PAGE Stained with Coomassie Blue. in vitro transl.
  Abnova Taiwan Corp.

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human Purified 12.5% SDS-PAGE Stained with Coomassie Blue.
  Abnova Taiwan Corp.

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human Purified 95 % E. coli
  GenWay Biotech Inc.

14-3-3 protein sigma / SFN

14-3-3 protein sigma / SFN Human Purified 95 % E. coli
  GenWay Biotech Inc.

14-3-3 protein sigma / SFN

Wetern Blot: 14-3-3 sigma/Stratifin Protein [NBP1-30172] - 15% SDS-PAGE (3ug)
  Novus Biologicals Inc.

Positive controls for 14-3-3 protein sigma / SFN (2 products)

Catalog No. Species Pres. Purity   Source  

14-3-3 sigma Lysate

Western Blot: 14-3-3 sigma/Stratifin  Lysate [NBL1-15882] - Western Blot experiments. 
Left-Control; Right -Over-expression Lysate for SFN
  Novus Biologicals Inc.

SFN overexpression lysate

SFN overexpression lysate
0.1 mg / €295.00
  OriGene Technologies, Inc.
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