GTX30644 4-amino Biphenyl DNA antibody

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0.1 ml / €470.00

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Mouse anti 4-amino Biphenyl DNA 4C11

Product Description for 4-amino Biphenyl DNA

Mouse anti 4-amino Biphenyl DNA 4C11.
Product is tested for Frozen Sections, Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for 4-amino Biphenyl DNA

Product Category Primary Antibodies
Quantity 0.1 ml
Applications C, E, ICC/IF, P
Clonality Monoclonal
Clone 4C11
Host Mouse
Shipping to Europe only
PDF datasheet View Datasheet
Manufacturer GeneTex Inc.

Datasheet Extract

4-amino Biphenyl DNA
Application ELISA, ICC, IF, IHC-Fr, IHC-P
Background 4-amino Biphenyl (4-ABP) is an aromatic amine (arylamine). 4-ABP can be found as a constituent of tobacco smoke, in the form of an environmental carcinogen. It is metabolized by hepatic cytochrome P4501A2 to yield a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Yet, the accumulation of biologically active metabolites is dependent on the activation and detoxification of N-acetylation. 4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well as genetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized that smokers may have higher levels of DNA adducts than non-smokers and that the role of 4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breast tumorigenesis. The antibody has been used to investigate the role of 4-ABP in the study of human breast cancer by measuring 4-ABP-DNA adducts.
Concentration 1.4 mg/ml
Storage Store at 4 degrees C. Long term (> 6 months) aliquot and store at
0.1 ml of Protein G purified mouse ascites [1.4 mg/ml] in PBS containing 0.1% Sodium Azide.
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