NB100-415 4-amino Biphenyl DNA antibody

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Mouse anti All Species 4-amino Biphenyl DNA 4C11

Product Description for 4-amino Biphenyl DNA

Mouse anti All Species 4-amino Biphenyl DNA 4C11.
Presentation: Purified
Product is tested for Enzyme Immunoassay, Immunocytochemistry/Immunofluorescence, Paraffin Sections.

Properties for 4-amino Biphenyl DNA

Product Category Primary Antibodies
Quantity 0.1 ml
Presentation Purified
Reactivity All Species
Applications E, ICC/IF, P
Clonality Monoclonal
Clone 4C11
Host Mouse
Isotype IgG
Shipping to Not USA/Canada
PDF datasheet View Datasheet
Manufacturer Novus Biologicals Inc.

Datasheet Extract

4-amino Biphenyl DNA
Application ELISA, Immunocytochemistry, immunofluorescence, immunohistochemistry, This antibody is useful for ELISA, immunohistochemistry, immunofluorescence and immunocytochemistry. *The investigator should determine the optimal working dilution for a specific application. , ELISA , immunohistochemistry 1:50-1:100, immunofluorescence , Immunocytochemistry 1:50-1:100
Background 4-amino Biphenyl (4-ABP) is an aromatic amine (arylamine). 4-ABP can be found as a constituent of tobacco smoke, in the form of an environmental carcinogen. It is metabolized by hepatic cytochrome P4501A2 to yield a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Yet, the accumulation of biologically active metabolites is dependent on the activation and detoxification of N-acetylation. 4-ABP has been shown to be a bladder carcinogen in humans and rodents. As well as genetic factors, 4-ABP may also play a role in breast cancer. It is hypothesized that smokers may have higher levels of DNA adducts than non-smokers and that the role of 4-ABP-DNA adducts and their relationship to tobacco exposure may be related to breast tumorigenesis. The antibody has been used to investigate the role of 4-ABP in the study of human breast cancer by measuring 4-ABP-DNA adducts.
Concentration 1.4 mg/ml
General Readings
  1. al-Atrash J, Zhang YJ, Lin D, Kadlubar FF, Santella RM. Quantitative immunohistochemical analysis of 4-aminobiphenyl-DNA in cultured cells and mice: comparison to gas chromatography/mass spectroscopy analysis. Chem Res Toxicol. 1995 Jul-Aug;8(5):747-52. PubMed PMID: 7548758.
  2. McQueen CA, Chau B. Neonatal ontogeny of murine arylamine N-acetyltransferases: implications for arylamine genotoxicity. Toxicol Sci. 2003 Jun;73(2):279-86. Epub 2003 Apr 15. PubMed PMID: 12700401.
  3. Faraglia B, Chen SY, Gammon MD, Zhang Y, Teitelbaum SL, Neugut AI, et al. Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: the influence of tobacco smoke. Carcinogenesis. 2003 Apr;24(4):719-25. PubMed PMID: 12727801.
  4. Brown, A., et al. Robust DNA Repair May Lower Breast Cancer Risk. Journal of the National Cancer Institute. 2005.
Storage Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
This is specific for 4-amino Biphenyl DNA.
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